Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache
Kaya Z, Belder N, Sever-Bahçekapılı M, Erdener Ş, Dönmez-Demir B, Bağcı C, Köroğlu M, Bilguvar K, Dalkara T. Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache. Brain 2025, awaf015. PMID: 39823578, DOI: 10.1093/brain/awaf015.Peer-Reviewed Original ResearchCortical spreading depolarizationCaspase-1 activationPost-CSDInflammatory signalingCell-specific transcriptomic dataMigraine headacheHMGB1 releaseCell-specific transcriptomesCaspase-1Inflammatory responseCell-specific activityUpregulation of genesPro-inflammatory transcriptsTranscriptome dataPro-inflammatory stimuliResolution of inflammationCo-immunoprecipitationTranscriptome analysisTranscriptomic responseFRET analysisCNS cell typesAnti-inflammatory responseAnti-inflammatory signalsAnti-inflammatory profileTranscriptional changes
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