Featured Publications
Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J
Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen M, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk B, Arnsten AFT, Huang Y, Carson RE, van Dyck C. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J. Alzheimer's & Dementia 2022, 18: 2527-2536. PMID: 35174954, PMCID: PMC9381645, DOI: 10.1002/alz.12582.Peer-Reviewed Original ResearchConceptsSynaptic densityEarly Alzheimer's diseaseAlzheimer's diseaseCognitive performanceMajor pathological correlateGray matter volumePositron emission tomography (PET) imagingEmission Tomography ImagingPET imaging studiesIndividual cognitive domainsNeuropathologic studiesSignificant positive associationSynapse lossSynaptic alterationsPathological correlatesNeuropsychological test performanceMatter volumeCognitive impairmentSignificant associationImaging studiesDiseaseTomography imagingGlobal cognitionStrongest predictorPositive association
2024
Design and implementation of community consultation for research conducted under exception from informed consent regulations for the PreVent and the PreVent 2 trials: Changes over time and during the COVID-19 pandemic.
Gugel T, Adams K, Baranoski M, Yanez N, Kampp M, Johnson T, Aydin A, Fajardo E, Sharp E, Potnis A, Johnson C, Treggiari M. Design and implementation of community consultation for research conducted under exception from informed consent regulations for the PreVent and the PreVent 2 trials: Changes over time and during the COVID-19 pandemic. Clinical Trials 2024, 17407745241243045. PMID: 38676438, DOI: 10.1177/17407745241243045.Peer-Reviewed Original ResearchPublic disclosure activitiesCommunity consultationInstitutional review boardConsent regulationsIn-personEmergency researchRegulatory measuresCOVID-19 pandemicPublic disclosureSponsor-investigatorsPublic supportPrevention experimentsCommunity leadersIn-person eventsYear of implementationFood and Drug AdministrationHigher education levelCommunity concernsReview boardSelection biasProportion of respondentsMethod of contactClinical researchLocal communitiesCOVID-19
2020
Gene-Environment Covariance as a Mechanism of Declines in Openness in Late Adulthood
Beam C, Sharp E. Gene-Environment Covariance as a Mechanism of Declines in Openness in Late Adulthood. Innovation In Aging 2020, 4: 462-462. PMCID: PMC7742976, DOI: 10.1093/geroni/igaa057.1495.Peer-Reviewed Original Research
2019
Openness Declines in Advance of Death in Late Adulthood
Sharp ES, Beam CR, Reynolds CA, Gatz M. Openness Declines in Advance of Death in Late Adulthood. Psychology And Aging 2019, 34: 124-138. PMID: 30667240, PMCID: PMC6441733, DOI: 10.1037/pag0000328.Peer-Reviewed Original Research
2018
Effects of Normative Adjustments to the Montreal Cognitive Assessment
Pugh EA, Kemp EC, van Dyck CH, Mecca AP, Sharp ES, Initiative F. Effects of Normative Adjustments to the Montreal Cognitive Assessment. American Journal Of Geriatric Psychiatry 2018, 26: 1258-1267. PMID: 30314940, PMCID: PMC6779033, DOI: 10.1016/j.jagp.2018.09.009.Peer-Reviewed Original Research
2017
Personality predicts mortality risk: An integrative data analysis of 15 international longitudinal studies
Graham E, Rutsohn J, Turiano N, Bendayan R, Batterham P, Gerstorf D, Katz M, Reynolds C, Sharp E, Yoneda T, Bastarache E, Elleman L, Zelinski E, Johansson B, Kuh D, Barnes L, Bennett D, Deeg D, Lipton R, Pedersen N, Piccinin A, Spiro A, Muniz-Terrera G, Willis S, Schaie K, Roan C, Herd P, Hofer S, Mroczek D. Personality predicts mortality risk: An integrative data analysis of 15 international longitudinal studies. Journal Of Research In Personality 2017, 70: 174-186. PMID: 29230075, PMCID: PMC5722274, DOI: 10.1016/j.jrp.2017.07.005.Peer-Reviewed Original ResearchPattern of protective effectsLow conscientiousnessHigh neuroticismIntegrative data analysisPersonality traitsOlder baseline ageInternational longitudinal studyExtraversionNeuroticismLongitudinal studyPredictor of mortality riskBaseline ageU.S. studiesPersonsMortality riskAgreeablenessConscientiousnessPredictorsPredictors of mortalityParticipantsTraitsSmokingProtective effectAgeStudyCOGNITIVE TRAJECTORY PATTERNS PREDICT INCIDENT DEMENTIA RISK IN OLDER SWEDISH ADULTS
Munoz E, Gatz M, Pedersen N, Sharp E, Reynolds C. COGNITIVE TRAJECTORY PATTERNS PREDICT INCIDENT DEMENTIA RISK IN OLDER SWEDISH ADULTS. Innovation In Aging 2017, 1: 708-708. PMCID: PMC6248351, DOI: 10.1093/geroni/igx004.2535.Peer-Reviewed Original ResearchSwedish Adoption/Twin StudyExecutive function tasksCognitive performance measuresDementia riskAverage performance levelEpisodic memoryFunction tasksVerbal domainSpatial abilityCognitive trajectoriesCognitive dataLevel of performanceAdditional tasksSwedish adultsHARMONY studyTwin studiesMemoryAge 65Dementia onsetPerformance levelTaskTotal sampleAdultsIncident dementiaLinear decline
2011
Relationship Between Education and Dementia
Sharp ES, Gatz M. Relationship Between Education and Dementia. Alzheimer Disease & Associated Disorders 2011, 25: 289-304. PMID: 21750453, PMCID: PMC3193875, DOI: 10.1097/wad.0b013e318211c83c.Peer-Reviewed Original Research
2010
Cognitive Engagement and Cognitive Aging: Is Openness Protective?
Sharp ES, Reynolds CA, Pedersen NL, Gatz M. Cognitive Engagement and Cognitive Aging: Is Openness Protective? Psychology And Aging 2010, 25: 60-73. PMID: 20230128, PMCID: PMC2853722, DOI: 10.1037/a0018748.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAlzheimer DiseaseCardiovascular DiseasesCognition DisordersDiseases in TwinsEducational StatusExploratory BehaviorFemaleHumansInterpersonal RelationsLeisure ActivitiesLongitudinal StudiesMaleMiddle AgedModels, PsychologicalMotivationSocial BehaviorStatistics as TopicSurveys and QuestionnairesTemperamentConceptsCognitive performanceSwedish Adoption/Twin StudyHigher cognitive test scoresLatent growth curve modelsCognitive test scoresGrowth curve modelsVerbal abilityCognitive agingCognitive domainsCognitive engagementCognitive testsSpatial abilityProcessing speedCognitive declineTest scoresLongitudinal trajectoriesHigh opennessTwin studiesCurve modelLongitudinal changesGlobal scoreOpennessDaily livingIndividualsMemory
2009
Does “No” Mean “Sometimes”? How Older Adults Respond to the Same Depression Symptoms with Different Response Formats
Sharp ES, Suthers KM, Crimmins E, Gatz M. Does “No” Mean “Sometimes”? How Older Adults Respond to the Same Depression Symptoms with Different Response Formats. Clinical Gerontologist 2009, 32: 371-378. PMID: 20563229, PMCID: PMC2885734, DOI: 10.1080/07317110903110385.Peer-Reviewed Original Research
2007
Survival of parents and siblings of supercentenarians.
Perls T, Kohler IV, Andersen S, Schoenhofen E, Pennington J, Young R, Terry D, Elo IT. Survival of parents and siblings of supercentenarians. The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences 2007, 62: 1028-34. PMID: 17895443, PMCID: PMC3258444, DOI: 10.1093/gerona/62.9.1028.Peer-Reviewed Original Research
2006
Serum heat shock protein 70 level as a biomarker of exceptional longevity.
Terry DF, Wyszynski DF, Nolan VG, Atzmon G, Schoenhofen EA, Pennington JY, Andersen SL, Wilcox MA, Farrer LA, Barzilai N, Baldwin CT, Asea A. Serum heat shock protein 70 level as a biomarker of exceptional longevity. Mechanisms Of Ageing And Development 2006, 127: 862-8. PMID: 17027907, PMCID: PMC1781061, DOI: 10.1016/j.mad.2006.08.007.Peer-Reviewed Original ResearchCharacteristics of 32 supercentenarians.
Schoenhofen EA, Wyszynski DF, Andersen S, Pennington J, Young R, Terry DF, Perls TT. Characteristics of 32 supercentenarians. Journal Of The American Geriatrics Society 2006, 54: 1237-40. PMID: 16913991, PMCID: PMC2895458, DOI: 10.1111/j.1532-5415.2006.00826.x.Peer-Reviewed Original Research
2004
Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring.
Terry DF, Wilcox MA, McCormick MA, Pennington JY, Schoenhofen EA, Andersen SL, Perls TT. Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring. Journal Of The American Geriatrics Society 2004, 52: 2074-6. PMID: 15571545, DOI: 10.1111/j.1532-5415.2004.52561.x.Peer-Reviewed Original ResearchCardiovascular disease delay in centenarian offspring: role of heat shock proteins.
Terry DF, McCormick M, Andersen S, Pennington J, Schoenhofen E, Palaima E, Bausero M, Ogawa K, Perls TT, Asea A. Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Annals Of The New York Academy Of Sciences 2004, 1019: 502-5. PMID: 15247074, PMCID: PMC1764488, DOI: 10.1196/annals.1297.092.Peer-Reviewed Original Research