Sourav Ghosh, PhD
Associate Professor; Associate Professor of Pharmacology
Research Interests
Astrocytes; Axons; Glioblastoma; Immune System; Nerve Regeneration; Neurology
Research Organizations
Research Summary
The overarching goal of the lab is to investigate molecular basis of diseases. We study signaling pathways in development and cell physiology, and strive to identify how the temporally and spatially inappropriate activity of these fundamental regulators can drive disease states. Current interests center on: (1) polarity signaling in neuronal development and regeneration, and aberrant polarity signaling in glioblastoma. (2) Neural and immune cell interaction in CNS development, regeneration and cancer. The goal of our studies is to unlock the potential for precision medicine by specifically targeting molecular pathways.
Specialized Terms: Neuronal polarity and axon specification in neurodevelopment and regeneration; immune cells and regeneration; astrocyte polarity signaling and glioblastoma; immune cells in glioblastoma;
Full List of PubMed Publications
- Hapak SM, Rothlin CV, Ghosh S: PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization. Cell Mol Life Sci. 2018 Aug; 2018 Apr 25. PMID: 29696344
- Hapak SM, Ghosh S, Rothlin CV: Axon Regeneration: Antagonistic Signaling Pairs in Neuronal Polarization. Trends Mol Med. 2018 Jul; 2018 Jun 19. PMID: 29934283
- Chibly AM, Wong WY, Pier M, Cheng H, Mu Y, Chen J, Ghosh S, Limesand KH: aPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1. Sci Rep. 2018 Apr 20; 2018 Apr 20. PMID: 29679075
- Chang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, Landreneau MJ, Ai Y, Beatty HE, da Costa LHA, Mack M, Sheth KN, Greer DM, Huttner A, Coman D, Hyder F, Ghosh S, Rothlin CV, Love JC, Sansing LH: Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage. J Clin Invest. 2018 Feb 1; 2017 Dec 18. PMID: 29251628
- Hughes LD, Bosurgi L, Ghosh S, Rothlin CV: Chronicles of Cell Death Foretold: Specificities in the Mechanism of Disposal. Front Immunol. 2017; 2017 Dec 11. PMID: 29312294
- Bosurgi L, Hughes LD, Rothlin CV, Ghosh S: Death begets a new beginning. Immunol Rev. 2017 Nov. PMID: 29027219
- Uribe DJ, Mandell EK, Watson A, Martinez JD, Leighton JA, Ghosh S, Rothlin CV: The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer. PLoS One. 2017; 2017 Jul 20. PMID: 28727830
- Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV: Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science. 2017 Jun 9; 2017 May 11. PMID: 28495875
- Akalu YT, Rothlin CV, Ghosh S: TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy. Immunol Rev. 2017 Mar. PMID: 28258690
- de Kouchkovsky DA, Ghosh S, Rothlin CV: Negative Regulation of Type 2 Immunity. Trends Immunol. 2017 Mar; 2017 Jan 9. PMID: 28082101
- Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV: The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science. 2016 Apr 1. PMID: 27034374
- Cox CM, Mandell EK, Stewart L, Lu R, Johnson DL, McCarter SD, Tavares A, Runyan R, Ghosh S, Wilson JM: Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Mol Biol Cell. 2015 Jul 15; 2015 May 20. PMID: 25995376
- Lu R, Dalgalan D, Mandell EK, Parker SS, Ghosh S, Wilson JM: PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Mol Biol Cell. 2015 Apr 15; 2015 Feb 18. PMID: 25694446
- Kusne Y, Carrera-Silva EA, Perry AS, Rushing EJ, Mandell EK, Dietrich JD, Errasti AE, Gibbs D, Berens ME, Loftus JC, Hulme C, Yang W, Lu Z, Aldape K, Sanai N, Rothlin CV, Ghosh S: Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma. Sci Signal. 2014 Aug 12; 2014 Aug 12. PMID: 25118327
- Rothlin CV, Leighton JA, Ghosh S: Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer. Inflamm Bowel Dis. 2014 Aug. PMID: 24846720
- Bosurgi L, Bernink JH, Delgado Cuevas V, Gagliani N, Joannas L, Schmid ET, Booth CJ, Ghosh S, Rothlin CV: Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Proc Natl Acad Sci U S A. 2013 Aug 6; 2013 Jul 22. PMID: 23878224
- Carrera Silva EA, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S, Rothlin CV: T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity. 2013 Jul 25; 2013 Jul 11. PMID: 23850380
