Brian B. Koo, MD

Associate Professor; Director, Sleep Medicine Program at Connecticut Veterans Affairs Healthcare System; Director, Yale Center for Restless Legs Syndrome

Departments & Organizations

Neurology: Movement Disorders

Center for Neuroepidemiology and Clinical Neurological Research

Faculty Research

Pulmonary, Critical Care & Sleep Medicine

Yale Medicine


     A graduate of the University of Pennsylvania (BA, 1995) and Tufts University School of Medicine (MD, 2001), Dr. Koo joined the Case Western Reserve School of Medicine faculty in 2008 and was subsequently recruited to Yale University in 2013. Dr. Koo’s primary clinical and research interests lie at the intersection between neurology and sleep medicine, in both of which he is board certified. Dr. Koo is particularly interested in the restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS), two very common sensorimotor problems that occur directly before or during sleep. His work concerning RLS and PLMS has occurred on different levels, including at the animal modeling, epidemiologic, human genetic, and neuropeptidal levels. Dr. Koo has received awards from the American Academy of Sleep Medicine for some of this work. Dr. Koo is a leading expert in the association between the cardiovascular diseases and the sleep-related movement disorders and has authored several peer-reviewed scientific publications on this topic. Currently, Dr. Koo's work focuses on assessing the role of the pro-opiomelanocortin-derived neuropeptides in RLS and he is actively recruiting participants to measure levels of these neurohormones in the serum and cerebrospinal fluid.
     Dr. Koo is director of the sleep laboratory at the Connecticut Veterans Affairs Healthcare System and the director of the Yale Center for Restless Legs Syndrome, an RLS Foundation sponsored Quality Care Center. Dr. Koo sees patients with sleep disorders at both Yale and the West Haven VA and is dedicated to the care of patients with both neurologic and sleep disorders.

Education & Training

MD Tufts University School of Medicine (2001)
BA University of Pennsylvania, Biological Basis of Behavior (1995)
Fellowship Case Western Reserve University
Fellowship Cleveland Clinic
Residency Long Island Jewish Hospital
Board Certification AB of Psychiatry & Neurology, Neurology (2006, recertified: 2016)
Board Certification AB of Psychiatry & Neurology, Sleep Medicine (2007, recertified: 2017)

Honors & Recognition

  • Sleep Research Network Junior Investigator Travel AwardSleep Research Network (2012)

  • American Academy of Sleep Medicine, Sleep-Related Movement Disorders Section Investigator AwardAmerican Academy of Sleep Medicine (2012)

  • American Academy of Sleep Medicine Young Investigator ForumAmerican Academy of Sleep Medicine (2012)

Professional Service

  • Restless Legs Syndrome Foundation (2015 - Present) Medical advisory board RLS Foundation

  • American Academy of Sleep Medicine: Restless Legs Syndrome Quality Care Task Force (2013 - 2014) Restless Legs Syndrome Quality Care Task Force

  • Sleep & Breathing (2013 - Present) Journal Editorial Board

  • Sleep-Related Movement Disorders Steering Committee Member, American Academy of Sleep Medicine (2012 - 2015) Steering Committee

  • Journal of Korean Sleep Research Society (2012 - Present) Journal Editorial Board

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Contact Info

Brian B. Koo, MD
Patient Care Locations
Yale NeurologyYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
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Yale Center for Sleep Medicine1291 Boston Post Road, Ste Suite 202
Madison, CT 06443
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Yale Pulmonary & Critical Care MedicineClinic Building
789 Howard Avenue, Ste Winchester Chest Clinic

New Haven, CT 06519
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Yale Center for Sleep Medicine8 Devine Street
North Haven, CT 06473
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Mailing Address
NeurologyPO Box 208018
New Haven, CT 06520-8018