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Yale Center for Restless Legs Syndrome

The Yale Center for Restless Legs Syndrome (YCRLS) within the Yale Departments of Neurology and Pulmonary, Critical Care, & Sleep Medicine are comprised of physicians and scientists dedicated to the recognition, evaluation, treatment, and understanding of restless legs syndrome (RLS). The group consists of physicians with differing backgrounds which include neurology, sleep medicine, and psychiatry. The primary goal of YCRLS is to provide excellent care for persons suffering from sensory, motor, psychologic, and sleep symptoms related to RLS.

The Yale Center for Restless Legs Syndrome is one of eight RLS Quality Care Centers in the world recognized and supported by the RLS Foundation. In addition, to expertise in RLS, practitioners in this center, have expertise in the assessment and treatment of sleep-disordered breathing, depression, and insomnia, conditions that are comorbid with RLS. Through the Yale Centers for Sleep Medicine, there is access to polysomnography, and through Yale Departments of Neurology and Radiology, there is access to neuroimaging. Treatment strategies include the use of the most up-to-date medications. In addition, within the same complex, there is an infusion center, where intravenous iron can be administered.

The other mission of the Yale Center for Restless Legs Syndrome is to increase understanding of RLS through investigation of this disorder.  We have ongoing clinical trials that patients may have the option of participating in. We are an active teaching center and provide learning opportunities to medical students, residents of neurology and internal medicine, and fellows in movement disorders, sleep medicine, and pulmonary medicine.  

  • Brian B. Koo

    Associate Professor; Director, Sleep Medicine Laboratory at Connecticut Veterans Affairs Healthcare System, Medicine; Director, Yale Center for Restless Legs Syndrome

         A graduate of the University of Pennsylvania (BA, 1995) and Tufts University School of Medicine (MD, 2001), Dr. Koo joined the Case Western Reserve School of Medicine faculty in 2008 and was subsequently recruited to Yale University in 2013. Dr. Koo’s primary clinical and research interests lie at the intersection between neurology and sleep medicine, in both of which he is board certified. Dr. Koo is particularly interested in the restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS), two very common sensorimotor problems that occur directly before or during sleep. His work concerning RLS and PLMS has occurred on different levels, including at the animal modeling, epidemiologic, human genetic, and neuropeptidal levels. Dr. Koo is an international expert in the restless legs syndrome and periodic limb movements during sleep and sees patients with RLS from across the tri-state area. Currently, Dr. Koo's work focuses on assessing the role of the pro-opiomelanocortin-derived neuropeptides in RLS, the association between hypothyroidism and RLS, and suicidal behavior in RLS. Other areas of research interest for Dr. Koo include the association between obstructive sleep apnea and wake-up stroke and the psychological phenomenon of demoralization in Parkinson Disease. 
         Dr. Koo is director of the sleep laboratory at the Connecticut Veterans Affairs Healthcare System and the director of the Yale Center for Restless Legs Syndrome, an RLS Foundation sponsored Quality Care Center. Dr. Koo sees patients with sleep disorders at both Yale and the West Haven VA and is dedicated to the care of patients with both neurologic and sleep disorders.