Objectives
Generation of neuronal progenitors derived from induced pluripotent stem cells.
Expand our repository of induced pluripotent cells (iPSC) from normal individuals and patients with neurological & psychiatric disorders
- Autism spectrum disorders
- Tourette Syndrome
- SCA13
Recapitulate the development of forebrain and other brain regions using the organoid approach
- in vitro & after transplantation
- tools to identify different CNS lineages
Perform cellular, molecular, genetic, epigenetic, and functional studies of undifferentiated/differentiated iPSC lines from patients and controls
Compare with postmortem human brain: http://psychencode.org/
- Single cell genomes and transcriptomes
- Genomic engineering using CRISPR
- Epigenetic analyses
Development of in vitro models for small molecules/drug screening for neuropsychiatric disorders