2023
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creation
2021
Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling
Cai Y, Wang XL, Lu J, Lin X, Dong J, Guzman RJ. Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2431-2451. PMID: 34196217, PMCID: PMC8411910, DOI: 10.1161/atvbaha.121.316219.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCell ProliferationCells, CulturedConstriction, PathologicCREB-Binding ProteinCyclic AMP-Dependent Protein KinasesCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27Disease Models, AnimalFemaleFemoral ArteryMaleMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaPhenylurea CompoundsProtein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktPyrimidinesRats, Sprague-DawleySignal TransductionTranscription FactorsVascular System InjuriesConceptsSmooth muscle cellsArterial restenosisNeointima formationSMC proliferationSMC migrationSIK inhibitionVascular smooth muscle cell proliferationPeripheral arterial diseaseSmooth muscle cell proliferationVascular smooth muscle cellsAortic smooth muscle cellsPotential therapeutic strategyMuscle cell proliferation
2018
Inhibition of endo-lysosomal function exacerbates vascular calcification
Cai Y, Wang XL, Flores AM, Lin T, Guzman RJ. Inhibition of endo-lysosomal function exacerbates vascular calcification. Scientific Reports 2018, 8: 3377. PMID: 29467541, PMCID: PMC5821871, DOI: 10.1038/s41598-017-17540-6.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsVascular calcificationAortic rings ex vivoChronic kidney diseaseMedial artery calcificationSmooth muscle cellsLysosomal inhibitor chloroquineCardiovascular morbidityArtery calcificationPathologic responseDiabetes mellitusAortic ringsKidney diseaseMedial calcificationVitamin D3Osteogenic transformationVSMC calcificationLysosomal marker lysosomeProtective roleLysosome inhibitionInhibitor chloroquineMembrane protein 2Ex vivoMuscle cellsCalcification