2003
Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation
Borg MA, Tamborlane WV, Shulman GI, Sherwin RS. Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation. Diabetes 2003, 52: 663-666. PMID: 12606506, DOI: 10.2337/diabetes.52.3.663.Peer-Reviewed Original ResearchConceptsCounterregulatory hormone responsesVentromedial hypothalamusHormone responseSprague-Dawley ratsGlucose-sensing mechanismHypoglycemic counterregulationSystemic hypoglycemiaHormonal suppressionLactate perfusionApproximate fourfold increaseGlucose metabolismMicrodialysis perfusionGlucose perfusionHormonal responsesHypoglycemic plateauHypoglycemiaPerfusionL-lactateExogenous glucoseFourfold increaseGlucoseLactate
1999
Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats.
Borg MA, Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS. Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. Diabetes 1999, 48: 584-587. PMID: 10078560, DOI: 10.2337/diabetes.48.3.584.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamusSystemic hypoglycemiaChronic hypoglycemiaCellular glucopeniaDefective counterregulationDiabetic BBNondiabetic BBDiabetic groupEpinephrine responseNorepinephrine responseCatecholamine responsesIatrogenic hypoglycemiaDiabetic ratsGlucagon releaseEfferent pathwaysSympathoadrenal systemControl ratsHypoglycemic ratsHypoglycemiaGlucopeniaCounterregulationRatsHypothalamusPerfusionCritical role
1997
Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.
Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. Journal Of Clinical Investigation 1997, 99: 361-365. PMID: 9006005, PMCID: PMC507804, DOI: 10.1172/jci119165.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamic nucleusMM D-glucoseControl groupGlucose perfusionHypoglycemic counterregulationSystemic hypoglycemiaNorepinephrine releaseGlucagon secretionCatecholamine concentrationsHypothalamic nucleiAwake ratsHormonal secretionControl animalsHypoglycemiaHormonal responsesPerfusionL glucoseCounterregulationD-glucoseGlucagonRatsSecretionGlucoseAnimalsGlucopenia
1996
Hyperleptinemia: an early sign of juvenile obesity. Relations to body fat depots and insulin concentrations
Caprio S, Tamborlane WV, Silver D, Robinson C, Leibel R, McCarthy S, Grozman A, Belous A, Maggs D, Sherwin RS. Hyperleptinemia: an early sign of juvenile obesity. Relations to body fat depots and insulin concentrations. American Journal Of Physiology 1996, 271: e626-e630. PMID: 8843759, DOI: 10.1152/ajpendo.1996.271.3.e626.Peer-Reviewed Original ResearchConceptsVisceral fat massLeptin levelsLeptin concentrationsFat depotsJuvenile obesityFat massInsulin concentrationsDb/db miceHyperglycemic clamp studiesAdult obese subjectsOb gene productDevelopment of obesityFa/fa ratsLeptin mRNA expressionSubcutaneous fat depotsMagnetic resonance imagingSpecific fat depotsObese subjectsNonobese subjectsObese childrenDb miceNonobese childrenAcute increaseObese stateHyperinsulinemic conditions
1994
Metabolic Effects of rhIGF-1 in Normal Human Subjects
Rennert NJ, Boulware SD, Kerr D, Caprio S, Tamborlane WV, Sherwin RS. Metabolic Effects of rhIGF-1 in Normal Human Subjects. Advances In Experimental Medicine And Biology 1994, 343: 311-318. PMID: 8184741, DOI: 10.1007/978-1-4615-2988-0_30.Peer-Reviewed Original ResearchConceptsRhIGF-1Hepatic glucose productionIGF-1Free fatty acidsGlucose productionGlucose uptakeEuglycemic clamp techniqueHuman IGF-1Normal human subjectsSpite of maintenanceSustained euglycemiaMetabolic effectsFFA levelsHypoglycemic effectClamp techniqueMetabolic actionsProfound reductionInsulinHypoglycemic hormoneFat cellsRatsComparable stimulationProtein breakdownSimilar extentEuglycemia
1991
Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats
Jacob RJ, Sherwin RS, Bowen L, Fryburg D, Fagin KD, Tamborlane WV, Shulman GI. Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats. American Journal Of Physiology 1991, 260: e262-e268. PMID: 1996629, DOI: 10.1152/ajpendo.1991.260.2.e262.Peer-Reviewed Original ResearchConceptsBB/W ratsBeta-hydroxybutyrate levelsDiabetic ratsNondiabetic ratsGlucose uptakeW ratsDiabetic BB/W ratsGlucose productionInsulin-like growth factor IIGF-I infusionDiabetic BB ratsInsulin-dependent diabetesMetabolic responseGrowth factor IHepatic glucose productionInsulin-stimulated glucose uptakeGlucose production rateBB ratsMetabolic effectsSimilar twofold increaseIGFRatsFactor IInsulinKetone concentrations