2016
Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury
Fink KL, Cafferty WB. Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury. Neurotherapeutics 2016, 13: 370-381. PMID: 26846379, PMCID: PMC4824020, DOI: 10.1007/s13311-016-0422-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEfferent PathwaysHumansMotor NeuronsNerve RegenerationNeuronal PlasticitySpinal CordSpinal Cord InjuriesConceptsSpinal cord injuryCentral nervous systemMotor pathwaysFunctional recoveryMotor functionMotor circuitsIntact circuitsIncomplete spinal cord injuryPartial spinal cord injuryAdult central nervous systemCorticospinal tract lesionsLimited spontaneous recoveryPermanent functional impairmentSpontaneous functional recoveryExperimental rodent modelsIntrinsic growth capacityRestoration of functionFine motor behaviorRaphespinal tractsDenervated sideTract lesionsCord injuryRubrospinal tractReticulospinal tractCNS neurons
2015
Plasticity of Intact Rubral Projections Mediates Spontaneous Recovery of Function after Corticospinal Tract Injury
Siegel CS, Fink KL, Strittmatter SM, Cafferty WB. Plasticity of Intact Rubral Projections Mediates Spontaneous Recovery of Function after Corticospinal Tract Injury. Journal Of Neuroscience 2015, 35: 1443-1457. PMID: 25632122, PMCID: PMC4308593, DOI: 10.1523/jneurosci.3713-14.2015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDesigner DrugsFunctional LateralityGene Expression RegulationGlial Fibrillary Acidic ProteinLocomotionMaleMiceMice, Inbred C57BLMice, TransgenicMuscle StrengthMyelin ProteinsNeuronal PlasticityNogo ProteinsPsychomotor DisordersPyramidal TractsRaphe NucleiRecovery of FunctionSpinal Cord InjuriesStereotyped BehaviorTime FactorsConceptsSpinal cord injurySpontaneous functional recoveryFunctional recoverySpontaneous recoveryIncomplete spinal cord injuryCorticospinal tract lesionsWeeks of lesionCorticospinal tract injuryNogo receptor 1Nucleus raphe magnusTract injuryRubrospinal projectionsTract lesionsCord injuryRaphe magnusCircuit rearrangementsAdult CNSCircuit plasticityLocomotor functionAdult micePharmacogenetic toolsRed nucleusRubral projectionReceptor 1Extensive sprouting
2013
Anatomical Plasticity of Adult Brain Is Titrated by Nogo Receptor 1
Akbik FV, Bhagat SM, Patel PR, Cafferty WB, Strittmatter SM. Anatomical Plasticity of Adult Brain Is Titrated by Nogo Receptor 1. Neuron 2013, 77: 859-866. PMID: 23473316, PMCID: PMC3594793, DOI: 10.1016/j.neuron.2012.12.027.Peer-Reviewed Original ResearchConceptsNgr1-/- miceNogo receptor 1Somatosensory cortexReceptor 1Adult cerebral cortexDendritic spine turnoverDendritic spine dynamicsAnatomical plasticityCerebral cortexControl miceSpine turnoverAxonal varicositiesWhisker removalAdult brainDendritic spinesSpine dynamicsNull miceAge 26Synaptic turnoverAnatomical connectivityConditional deletionMiceLower set pointNgR1Cortex
2011
Myelin associated inhibitors: A link between injury-induced and experience-dependent plasticity
Akbik F, Cafferty WB, Strittmatter SM. Myelin associated inhibitors: A link between injury-induced and experience-dependent plasticity. Experimental Neurology 2011, 235: 43-52. PMID: 21699896, PMCID: PMC3189418, DOI: 10.1016/j.expneurol.2011.06.006.Peer-Reviewed Original ResearchConceptsExperience-dependent plasticityAnatomical rearrangementsNogo-66 receptor 1Spinal cord injuryNeurologic recoveryFunctional recoveryInciting stimulusCNS injuryCord injuryAxonal regenerationAdult CNSInjury studiesAnimal modelsReceptor 1Common receptorPaired-ImmunoglobulinMyelinInhibitorsInjuryAnatomical growthCNSReceptorsWide spectrumExtracellular matrixGrowth inhibitor
2008
Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function
Cafferty WB, Bradbury EJ, Lidierth M, Jones M, Duffy PJ, Pezet S, McMahon SB. Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function. Journal Of Neuroscience 2008, 28: 11998-12009. PMID: 19005065, PMCID: PMC3844838, DOI: 10.1523/jneurosci.3877-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAfferent PathwaysAnimalsChondroitin ABC LyaseChondroitin Sulfate ProteoglycansDisease Models, AnimalMaleNerve RegenerationNeural ConductionNeuronal PlasticityRatsRats, WistarRecovery of FunctionRhizotomySensation DisordersSensory Receptor CellsSpinal CordSpinal Cord InjuriesSpinal Nerve RootsTreatment OutcomeConceptsSpinal cord injuryFunctional restorationSensory functionSpinal sensory functionsPrimary afferent terminalsVivo electrophysiological recordingsIntact spinal circuitsEnzyme chondroitinase ABCIntrinsic growth potentialAfferent terminalsBehavioral recoveryIntraspinal injectionCord injurySensory deficitsSpinal cordSpinal circuitsAdult ratsMature CNSTherapeutic interventionsExperimental therapeuticsElectrophysiological recordingsAxon growthInjuryIntact pathwaysEnhance functionAxonal growth therapeutics: regeneration or sprouting or plasticity?
Cafferty WB, McGee AW, Strittmatter SM. Axonal growth therapeutics: regeneration or sprouting or plasticity? Trends In Neurosciences 2008, 31: 215-220. PMID: 18395807, PMCID: PMC2678051, DOI: 10.1016/j.tins.2008.02.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesAxonsChondroitin Sulfate ProteoglycansMyelin SheathNerve RegenerationNeuronal PlasticitySignal TransductionConceptsAxonal growthAstroglial scarHigh clinical significanceFunctional recoveryNeurological injuryInciting eventFunctional deficitsSpinal cordClinical significanceAdult brainLoss of functionCell lossInhibitory factorAxonal connectivityAxonal anatomyAxonal extensionMolecular interventionsMyelinScarCordInjuryBrain