2007
Functional Axonal Regeneration through Astrocytic Scar Genetically Modified to Digest Chondroitin Sulfate Proteoglycans
Cafferty WB, Yang SH, Duffy PJ, Li S, Strittmatter SM. Functional Axonal Regeneration through Astrocytic Scar Genetically Modified to Digest Chondroitin Sulfate Proteoglycans. Journal Of Neuroscience 2007, 27: 2176-2185. PMID: 17329414, PMCID: PMC2848955, DOI: 10.1523/jneurosci.5176-06.2007.Peer-Reviewed Original ResearchConceptsChondroitin sulfate proteoglycanRole of CSPGsTransgenic miceSensory axon regenerationMotor function recoveryFunctional axonal regenerationCombination-based therapyEnzyme chondroitinase ABCSulfate proteoglycanDorsal hemisectionAxotomized neuronsDorsal rhizotomyCorticospinal axonsCNS injuryFunction recoveryMyelin inhibitorsAxonal regenerationAstrocytic scarLocal efficacyTraumatic injuryAxon regenerationLesion siteInhibitory moleculesFunctional regenerationChondroitinase ABC
2005
Regulation of neuropilin 1 by spinal cord injury in adult rats
Agudo M, Robinson M, Cafferty W, Bradbury EJ, Kilkenny C, Hunt SP, McMahon SB. Regulation of neuropilin 1 by spinal cord injury in adult rats. Molecular And Cellular Neuroscience 2005, 28: 475-484. PMID: 15737738, DOI: 10.1016/j.mcn.2004.10.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDorsal hornCord injurySpinal cordAdult ratsAdjacent dorsal root gangliaNeuropilin-1Dorsal root rhizotomyDorsal root gangliaUnilateral rhizotomyMicroglial cellsRoot gangliaSensory projectionsControl animalsRhizotomyWestern blottingBlood vesselsInjuryRT-PCRSuperficial layersCordLesionsRatsSitu hybridizationHorn