2015
Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains
de Arce K, Schrod N, Metzbower SWR, Allgeyer E, Kong G, Tang AH, Krupp AJ, Stein V, Liu X, Bewersdorf J, Blanpied TA, Lucić V, Biederer T. Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains. Neuron 2015, 88: 1165-1172. PMID: 26687224, PMCID: PMC4687029, DOI: 10.1016/j.neuron.2015.11.011.Peer-Reviewed Original ResearchConceptsSynaptic cell adhesion molecule 1Trans-synaptic complexesEphB2 receptor tyrosine kinaseReceptor tyrosine kinasesCryo-ETSynaptic cleftCryoelectron tomographyTyrosine kinaseMolecular insightsSynCAM 1Macromolecular organizationImmunoglobulin proteinCell adhesion molecule-1Immunoelectron microscopyAdhesion molecule-1Super-resolution imagingPostsynaptic densityDistinct density profilesDepression paradigmExcitatory synapsesPostsynaptic areaMolecule-1Cleft edgesSynapsesCleft
2010
SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning
Robbins EM, Krupp AJ, de Arce K, Ghosh AK, Fogel AI, Boucard A, Südhof TC, Stein V, Biederer T. SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning. Neuron 2010, 68: 894-906. PMID: 21145003, PMCID: PMC3026433, DOI: 10.1016/j.neuron.2010.11.003.Peer-Reviewed Original ResearchConceptsSynapse numberSynCAM 1Excitatory synapse numberLong-term depressionActivity-dependent changesTransgenic brainsExcitatory synapsesMature synapsesTransgenic miceNeuronal connectivityNeuronal circuitsSynapse developmentSpatial learningAdhesion moleculesNeuronal networksSynapsesAdult networksMiceBrainOverexpressionPlasticityExpressionSynaptogenesis