2017
Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies
Wiesch P, Clarelli F, Cohen T. Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies. PLOS Computational Biology 2017, 13: e1005321. PMID: 28060813, PMCID: PMC5257006, DOI: 10.1371/journal.pcbi.1005321.Peer-Reviewed Original ResearchConceptsOptimal dosingTreatment strategiesOnset of actionAntibiotic treatment strategiesAntibiotic concentrationsOptimal therapyFrequent dosingHigh dosesBacterial infectionsDrug concentrationsDosingBacterial replicationAntibioticsPhysiological fluctuationsAntibiotic effectCellsHIVBacterial growthTherapyCancerInfectionMalariaDoses
2015
Classic reaction kinetics can explain complex patterns of antibiotic action
Abel Zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, Cohen T. Classic reaction kinetics can explain complex patterns of antibiotic action. Science Translational Medicine 2015, 7: 287ra73. PMID: 25972005, PMCID: PMC4554720, DOI: 10.1126/scitranslmed.aaa8760.Peer-Reviewed Original ResearchConceptsOptimal dosing strategiesAntibiotic treatment strategiesTime-kill curvesAntibiotic effectGrowth suppressionCell formationChemotherapeutic regimensClinical trialsDosing strategiesTreatment strategiesTuberculosis therapyPersister cell formationDrug effectsBacterial infectionsVariety of antibiotics