Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene
La Cognata V, Iemmolo R, D’Agata V, Scuderi S, Drago F, Zappia M, Cavallaro S. Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene. Current Genomics 2014, 15: 203-216. PMID: 24955028, PMCID: PMC4064560, DOI: 10.2174/1389202915666140426003342.Peer-Reviewed Original ResearchAlternative splicingTrans-acting mutationsE3 ubiquitin protein ligaseHuman disease genesMultiple protein isoformsUbiquitin-protein ligaseExtensive alternative splicingParkinson protein 2Alternative splice transcriptsHuman Genome ProjectTranscriptomic diversificationProtein diversityCellular lifeIndividual genesWidespread mechanismGenetic regulationProtein ligasePrimary transcriptProtein isoformsSingle geneSplicing featuresGenome ProjectCoding PotentialDisease genesSplicing