520. Longitudinal Analysis of SARS-CoV-2 Viruses in Hospitalized Adults
Simons L, Lorenzo-Redondo R, Nam H, Roberts S, Ison M, Achenbach C, Hauser A, Ozer E, Hultquist J. 520. Longitudinal Analysis of SARS-CoV-2 Viruses in Hospitalized Adults. Open Forum Infectious Diseases 2020, 7: s325-s326. PMCID: PMC7776408, DOI: 10.1093/ofid/ofaa439.714.Peer-Reviewed Original ResearchSARS-CoV-2 viral loadViral loadSARS-CoV-2Hospitalized adultsPositive SARS-CoV-2 testSARS-CoV-2 testWhole viral genome sequencingNasopharyngeal viral loadResults 60 patientsNorthwestern Memorial HospitalCoronavirus disease 2019Viral load dataSARS-CoV-2 virusImmune selective pressureViral genome sequencingQuantitative reverse transcriptase PCRReverse transcriptase-PCRNasopharyngeal specimensNasopharyngeal swabsMemorial HospitalClinical dataIndividual patientsClinical consequencesDisease 2019Immune pressureA clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways
Lorenzo-Redondo R, Nam HH, Roberts SC, Simons LM, Jennings LJ, Qi C, Achenbach CJ, Hauser AR, Ison MG, Hultquist JF, Ozer EA. A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways. EBioMedicine 2020, 62: 103112. PMID: 33186810, PMCID: PMC7655495, DOI: 10.1016/j.ebiom.2020.103112.Peer-Reviewed Original ResearchConceptsPatient's upper airwayViral loadSARS-CoV-2Upper airwayHighest average viral loadSARS-CoV-2 infectionTranslational Research AwardTime of diagnosisAverage viral loadCOVID-19 patientsLow viral loadComprehensive cancer centerCoronavirus disease 2019SARS-CoV-2 isolatesSARS-CoV-2 virusClade 1 virusesClade 2 virusesRelative viral loadVirologic featuresClinical characteristicsClinical parametersCancer CenterDistinct viral cladesClinical significanceTranslational Science Institute