2016
A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence
Carroll KM, Nich C, Petry NM, Eagan DA, Shi JM, Ball SA. A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence. Drug And Alcohol Dependence 2016, 160: 135-142. PMID: 26817621, PMCID: PMC4767616, DOI: 10.1016/j.drugalcdep.2015.12.036.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCocaine outcomesCocaine dependenceCombination of CMDouble-blind clinical trialBehavioral therapyCommunity-based outpatient clinicsUrine sample testingBlind clinical trialSustained treatment effectContingency managementDSM-IV criteriaRandomized factorial trialCurrent cocaine dependenceWeekly individual sessionsCocaine use disorderSecondary outcomesPrimary outcomeYear followOutpatient clinicAddition of disulfiramClinical trialsUse disordersCBT treatmentFactorial trial
2014
Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram
DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram. Drug And Alcohol Dependence 2014, 145: 156-167. PMID: 25457739, PMCID: PMC4268325, DOI: 10.1016/j.drugalcdep.2014.10.007.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsClinical outcomesTreatment outcomesCocaine dependenceBehavioral therapyBehavioral treatment conditionsPoor treatment outcomesEvidence-based treatmentsGender differencesWidespread clinical implementationPoor outcomePharmacological treatmentMedication conditionAddiction pharmacotherapyCocaine useSecondary analysisBehavioral treatmentClinical implementationWomenCareful assessmentDisulfiramOutcomesTrialsMen
2012
Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial
Carroll KM, Nich C, Shi JM, Eagan D, Ball SA. Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial. Drug And Alcohol Dependence 2012, 126: 224-231. PMID: 22695473, PMCID: PMC3461119, DOI: 10.1016/j.drugalcdep.2012.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcohol DrinkingCocaine-Related DisordersCounselingDemographyDiagnostic and Statistical Manual of Mental DisordersDisulfiramDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMethadoneNarcoticsOpiate Substitution TreatmentPatient ComplianceRegression AnalysisSelf-Help GroupsSocioeconomic FactorsSubstance Abuse DetectionTreatment OutcomeConceptsMethadone maintenance programEfficacy of disulfiramAlcohol use disorderCocaine useStandard counselingUse disordersCommunity-based methadone maintenance programRandomized placebo-controlled trialPlacebo-controlled trialCurrent alcohol use disorderTwelve-step facilitationCocaine-negative urinesLess cocaine useMethadone maintenanceStep FacilitationCocaine-dependent individualsPlaceboBetter outcomesDisulfiram efficacyTreatment approachesFactorial trialDisulfiramMaintenance programRelative efficacyCocaine users
2007
The Impact of Personality Disorders on Alcohol‐Use Outcomes in a Pharmacotherapy Trial for Alcohol Dependence and Comorbid Axis I Disorders
Ralevski E, Ball S, Nich C, Limoncelli D, Petrakis I. The Impact of Personality Disorders on Alcohol‐Use Outcomes in a Pharmacotherapy Trial for Alcohol Dependence and Comorbid Axis I Disorders. American Journal On Addictions 2007, 16: 443-449. PMID: 18058408, DOI: 10.1080/10550490701643336.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcoholismAntisocial Personality DisorderBehavior, AddictiveBorderline Personality DisorderComorbidityDiagnostic and Statistical Manual of Mental DisordersDisulfiramFemaleHumansMaleMental DisordersMiddle AgedNaltrexoneNarcotic AntagonistsPatient CompliancePersonality DisordersPlacebosPsychiatric Status Rating ScalesTreatment OutcomeConceptsBorderline personality disorderAxis I DisordersAlcohol dependenceAlcohol use outcomesPersonality disorderI disordersAxis IComorbid Axis I disordersContext of pharmacotherapyAxis II disordersMajor Axis IMedication trialsPharmacotherapy trialsPoor responseOutcome measuresPatientsNaltrexoneAlcohol useDiagnosisUse outcomesDiagnosis of antisocialDisordersDisulfiramOutcomesASPD
2004
Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-DependentOutpatients: A Randomized Placebo-Controlled Trial
Carroll KM, Fenton LR, Ball SA, Nich C, Frankforter TL, Shi J, Rounsaville BJ. Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-DependentOutpatients: A Randomized Placebo-Controlled Trial. JAMA Psychiatry 2004, 61: 264-272. PMID: 14993114, PMCID: PMC3675448, DOI: 10.1001/archpsyc.61.3.264.Peer-Reviewed Original ResearchConceptsCocaine useGeneral populationCocaine dependenceEfficacy of disulfiramUrine toxicology screenOutpatient substance abuse treatment programsBehavior therapyConcurrent alcohol useSubstance abuse treatment programsCurrent cocaine dependenceCognitive behavior therapyDisulfiram useRandomized PlaceboDisulfiram therapyMedication complianceToxicology screenIdentical capsulesEffective therapyPlaceboCocaine-dependent individualsSelf-reported frequencyPromising treatmentPlacebo conditionInterpersonal psychotherapyTherapy
2000
One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment
Carroll K, Nich C, Ball S, McCance E, Frankforter T, Rounsaville B. One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment. Addiction 2000, 95: 1335-1349. PMID: 11048353, DOI: 10.1046/j.1360-0443.2000.95913355.x.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentTwelve-step facilitationInitiation of abstinenceAlcohol useSubstance abuse treatment centersFrequency of cocaineAlcohol-dependent individualsClinical managementMain effectBrief treatmentEfficacy of disulfiramUrine toxicology screenCessation of treatmentBreathalyzer testEnd of treatmentOutcomes 1 yearAbstinencePercentage of daysEffect of treatmentCocaineLong-term benefitsToxicology screenTreatment centersBetter outcomesBrief period
1998
Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram
Carroll KM, Nich C, Ball SA, McCance E, Rounsavile BJ. Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction 1998, 93: 713-727. PMID: 9692270, DOI: 10.1046/j.1360-0443.1998.9357137.x.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentAlcohol useClinical managementCocaine useConcurrent alcohol abuseDrug use disordersTreatment of cocaineCo-morbid disordersPromising treatment strategySubstance abuse treatment centersTreatment-seeking cocaine abusersUrine toxicologyDrug-dependent individualsContinuous abstinenceDisulfiram treatmentStep FacilitationTreatment strategiesCocaine-dependent individualsAlcohol abuseAlcohol abusersUse disordersTreatment centersSupportive psychotherapyAlcohol dependenceActive psychotherapy