2025
Short-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection
Jiang B, Ren P, He C, Wang M, Murtada S, Ruiz-Rodríguez M, Chen Y, Ramachandra A, Li G, Qin L, Assi R, Schwartz M, Humphrey J, Tellides G. Short-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection. JCI Insight 2025, 10 PMID: 39932797, PMCID: PMC11949005, DOI: 10.1172/jci.insight.182629.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsBlood pressureAortic dissectionAdult miceInherited connective tissue disorderConnective tissue disordersTGF-b signalingAccumulation of bloodHigh blood pressureAortic phenotypeTissue disordersMolecule expressionTGFB signalingMuscle cellsRisk factorsSynthesis of extracellular matrixSustained increaseTransient increaseBlood extravasationDissectionMedial injuryExtracellular matrix productionVascular degenerationExperimental modelMice
2023
Thoracic Endovascular Aortic Repair vs Medical Therapy Alone for Uncomplicated Acute Type B Aortic Dissection
Hu K, Pupovac S, Hameed I, Zafar M, Fereydooni S, Li E, Ma W, Williams M, Assi R, Nassiri N, Vallabhajosyula P. Thoracic Endovascular Aortic Repair vs Medical Therapy Alone for Uncomplicated Acute Type B Aortic Dissection. Journal Of Vascular Surgery 2023, 77: e270. DOI: 10.1016/j.jvs.2023.03.378.Peer-Reviewed Original Research
2021
Management of Chronic Descending Thoracic and Thoracoabdominal Dissection and Aneurysm - Stent Grafting, Debranching
Assi R, Szeto W. Management of Chronic Descending Thoracic and Thoracoabdominal Dissection and Aneurysm - Stent Grafting, Debranching. 2021, 409-422. DOI: 10.1007/978-3-030-66668-2_29.Peer-Reviewed Original ResearchChronic type B aortic dissectionType B aortic dissectionB aortic dissectionEndovascular repairAortic dissectionTreatment modalitiesFalse lumen thrombosisOnly treatment modalityOpen surgical reconstructionDifferent treatment modalitiesStent-graft devicesDescending ThoracicThoracoabdominal dissectionAortic remodelingPerioperative morbidityEntry tearSurgical reconstructionAortic anatomyAortic degenerationNatural historyDissectionDiseaseComplex diseasesModalitiesComplex cases
2020
Midterm outcomes and durability of sinus segment preservation compared with root replacement for acute type A aortic dissection
Bojko MM, Assi R, Bavaria JE, Suhail M, Habertheuer A, Hu RW, Harmon J, Milewski RK, Desai ND, Szeto WY, Vallabhajosyula P. Midterm outcomes and durability of sinus segment preservation compared with root replacement for acute type A aortic dissection. Journal Of Thoracic And Cardiovascular Surgery 2020, 163: 900-910.e2. PMID: 32620395, DOI: 10.1016/j.jtcvs.2020.04.064.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedAortic AneurysmAortic DissectionAortic ValveAortic Valve InsufficiencyBlood Vessel Prosthesis ImplantationCardiac Surgical ProceduresFemaleHumansMaleMiddle AgedPostoperative ComplicationsRecurrenceReoperationRetrospective StudiesRisk AssessmentRisk FactorsSinus of ValsalvaTime FactorsTreatment OutcomeConceptsAcute typeRoot replacementAortic dissectionAortic insufficiencyRoot repairCumulative incidenceReplacement groupPostoperative aortic insufficiencyProximal aortic reoperationsRoot replacement groupMultivariable Cox regressionSinus of ValsalvaLongitudinal mixed modelsAortic reoperationValsalva dimensionsMidterm outcomesRoot dilationCox regressionFunctional outcomeRisk factorsReoperationSinusInsufficiencyDissectionMixed effects models
2018
Techniques and outcomes of secondary open repair for chronic dissection after acute repair of type A aortic dissection.
Assi R, Bavaria JE, Desai ND. Techniques and outcomes of secondary open repair for chronic dissection after acute repair of type A aortic dissection. The Journal Of Cardiovascular Surgery 2018, 59: 759-766. PMID: 29943963, DOI: 10.23736/s0021-9509.18.10646-x.Peer-Reviewed Original ResearchConceptsAortic dissectionSecondary open repairThoraco-abdominal aortaDistal false lumenRisk of ruptureAcute TAADChronic dissectionAcceptable morbidityAcute typeAcute repairPrimary tearDistal aortaOpen repairAneurysmal dilatationFalse lumenDistal reoperationExperienced handsIndex operationProgressive degenerationSuccessful repairAortaDissectionHybrid procedureRepairReoperation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply