2024
Heterogeneous Cardiac-Derived and Neural Crest–Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption
Ren P, Jiang B, Hassab A, Li G, Li W, Assi R, Tellides G. Heterogeneous Cardiac-Derived and Neural Crest–Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption. Arteriosclerosis Thrombosis And Vascular Biology 2024, 45: 260-276. PMID: 39697172, DOI: 10.1161/atvbaha.124.321706.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic AneurysmCell LineageDisease Models, AnimalGene Expression ProfilingHomeobox Protein Nkx-2.5HumansMaleMarfan SyndromeMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleMyosin Heavy ChainsNeural CrestPhenotypeReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaSignal TransductionSingle-Cell AnalysisTranscription, GeneticTranscriptomeTransforming Growth Factor betaWnt1 ProteinConceptsSmooth muscle cell clustersSmooth muscle cellsAortic smooth muscle cellsNeural crest-derived smooth muscle cellsCardiac derivativesMurine aortic smooth muscle cellsNeural crest originReceptor deletionAortic rootAdult miceNeural crest progenitorsNKX2-5Proximal aortaTranscriptional changesMouse modelTGFB signalingMuscle cellsConditional deletionAdult human aortaEmbryological originIncreased expressionAnalyzed single-cell transcriptomesTGFB receptorsBasal stateAortic homeostasis
2023
TAVR explant with aortic root replacement using a homograft for an aortic rupture.
Singh S, Vallabhajosyula P, Geirsson A, Assi R. TAVR explant with aortic root replacement using a homograft for an aortic rupture. Multimedia Manual Of Cardio-Thoracic Surgery 2023, 2023 PMID: 36644957, DOI: 10.1510/mmcts.2022.101.Peer-Reviewed Original ResearchConceptsLeft coronary buttonAortic ruptureCoronary buttonsAortic rootAortic root replacementTranscatheter aortic valve prosthesisAortic valve prosthesisTAVR explantRoot replacementMale presentingCase reportTranscatheter prosthesesValve prosthesisStent frameBovine pericardiumProsthesisRuptureHaemopericardiumPseudoaneurysmHomograftsPresenting
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