2024
Stress and substance use disorders: risk, relapse, and treatment outcomes
Sinha R. Stress and substance use disorders: risk, relapse, and treatment outcomes. Journal Of Clinical Investigation 2024, 134: e172883. PMID: 39145454, PMCID: PMC11324296, DOI: 10.1172/jci172883.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalHumansRecurrenceRisk FactorsStress, PsychologicalSubstance-Related DisordersTreatment OutcomeConceptsSubstance use disordersDrug-related environmentPathophysiology of addictionAdaptive stress responseSUD treatment outcomesAssociated with substance misuseTreatment outcomesStress-related alterationsDrug motivationIncreased cravingNeurobiological disruptionsMaladaptive copingRepeated stressorsTreatment implicationsSubstance misuseStress pathophysiologyStress responseDrug intakeDrug withdrawalRelapse riskDrug misuseIntervention developmentDisordersCravingRelapseSubstance use patterns, quantities, and associated risk factors in women with polysubstance misuse
Fogelman N, Tate M, Wemm S, Sullivan L, Hart R, Vacey E, Fox H, Sinha R. Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse. Addiction Biology 2024, 29: 10.1111/adb.13390. PMID: 38619491, PMCID: PMC11017971, DOI: 10.1111/adb.13390.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidAnxietyCross-Sectional StudiesFemaleHumansPainRisk FactorsSubstance-Related DisordersConceptsPolysubstance useDepressive symptomsSubstance use patternsDrug cravingRisk factorsPatterns of polysubstance useSingle substance useAssociated with polysubstance usePlacebo-controlled studyHigher cravingGuanfacine treatmentCross-sectional observational studyPolysubstance use patternsCraving managementLife eventsCravingPolysubstance misuseSubstance useOpioid amountsPain ratingsStress/traumaObservational studyAnxietyPainPolysubstance
2023
A thematic analysis of stress, substance-cue, and neutral/relaxing events to inform approaches for improving treatment among Black adults who use substances
Haeny A, Chowdhary A, King J, Sypher I, O'Malley S, Sinha R. A thematic analysis of stress, substance-cue, and neutral/relaxing events to inform approaches for improving treatment among Black adults who use substances. Journal Of Substance Use And Addiction Treatment 2023, 156: 209184. PMID: 37866439, DOI: 10.1016/j.josat.2023.209184.Peer-Reviewed Original ResearchAdaptation, PsychologicalAdultBlack PeopleCuesFemaleHumansMaleSex CharacteristicsSubstance-Related DisordersTransdiagnostic Connectome-Based Prediction of Craving
Garrison K, Sinha R, Potenza M, Gao S, Liang Q, Lacadie C, Scheinost D. Transdiagnostic Connectome-Based Prediction of Craving. American Journal Of Psychiatry 2023, 180: 445-453. PMID: 36987598, DOI: 10.1176/appi.ajp.21121207.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveBrainConnectomeCravingCuesHumansMagnetic Resonance ImagingSubstance-Related DisordersConceptsConnectome-based predictive modelingImagery conditionFunctional connectomeSelf-reported cravingStudy of motivationDefault mode networkFunctional connectivity dataIndependent samplesKey phenomenological featuresNeural signaturesTransdiagnostic sampleTransdiagnostic perspectiveMode networkMotivated behaviorCentral constructAddictive disordersHuman behaviorConnectivity dataPhenomenological featuresStrongest predictorCravingTaskSubstance use-related disordersConnectomeIndividualsSex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder
Smith K, Lacadie C, Milivojevic V, Fogelman N, Sinha R. Sex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder. Drug And Alcohol Dependence 2023, 244: 109794. PMID: 36758371, PMCID: PMC10024802, DOI: 10.1016/j.drugalcdep.2023.109794.Peer-Reviewed Original ResearchMeSH KeywordsBrainCuesFemaleHumansMagnetic Resonance ImagingMalePrefrontal CortexSex CharacteristicsSubstance-Related DisordersConceptsSubstance use disordersDrug cuesFuture drug useDrug use daysCue exposureNeural responsesUse daysSex differencesVentromedial prefrontal cortexScript-driven imageryDrug cue exposureNeutral cue exposureWhole-brain analysisWhole-brain correlationUse disordersDrug use outcomesCue-induced anxietyBrain responsesHeart rateFMRI scansPrefrontal cortexDrug cravingDrug useBrain analysisBrain correlationsRegular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample
Bassir Nia A, Weleff J, Fogelman N, Nourbakhsh S, Sinha R. Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample. Journal Of Psychiatric Research 2023, 159: 159-164. PMID: 36736285, PMCID: PMC10024801, DOI: 10.1016/j.jpsychires.2023.01.036.Peer-Reviewed Original ResearchMeSH KeywordsCannabisCocaineCross-Sectional StudiesFemaleHumansSubstance-Related DisordersSurveys and QuestionnairesConceptsMajor life eventsChildhood traumaLife eventsChildhood Trauma QuestionnaireLifetime traumaCannabis useNon-clinical community sampleChronic stressNeurobiology of stressRegular cannabis useGender differencesRegular useSelf-report questionnairesRecent life eventsPotential gender differencesCross-sectional studyUrine drug testingLife traumaLogistic regression analysisAdversity indexCommunity sampleCannabis usersTrauma QuestionnaireHigh rateSubstance use
2018
Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability
Milivojevic V, Sinha R. Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability. Trends In Molecular Medicine 2018, 24: 173-186. PMID: 29396148, PMCID: PMC6511993, DOI: 10.1016/j.molmed.2017.12.010.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveBiomarkersCentral Nervous SystemHumansPeripheral Nervous SystemRecurrenceRisk FactorsStress, PsychologicalSubstance-Related DisordersConceptsSubstance use disordersTreatment of SUDsDevelopment of SUDHigh relapse rateFunctional brain alterationsCentral stress responseAdrenal axis markersStress response measuresRelapse ratePeripheral biomarkersClinical symptomatologyBrain alterationsUse disordersCandidate biomarkersAutonomic responsesRelapse vulnerabilityPutative biomarkersAddiction riskStress responseBiomarkersTreatmentResponsePathophysiologySymptomatologyPrevention
2008
Chronic Stress, Drug Use, and Vulnerability to Addiction
Sinha R. Chronic Stress, Drug Use, and Vulnerability to Addiction. Annals Of The New York Academy Of Sciences 2008, 1141: 105-130. PMID: 18991954, PMCID: PMC2732004, DOI: 10.1196/annals.1441.030.Peer-Reviewed Original ResearchMeSH KeywordsArousalChronic DiseaseCorticotropin-Releasing HormoneDisease SusceptibilityEmotionsFemaleHumansHypothalamo-Hypophyseal SystemIllicit DrugsLimbic SystemMaleNeurotransmitter AgentsPituitary-Adrenal SystemRewardSelf MedicationStress, PhysiologicalStress, PsychologicalSubstance Withdrawal SyndromeSubstance-Related DisordersSympathetic Nervous SystemConceptsCompulsive drug seekingStress-related riskDevelopment of addictionChronic drug useEarly life stressMotivational systemsIndividual-level variablesRelapse susceptibilityRelapse vulnerabilityDrug seekingAutonomic arousalDrug useLife stressDrug-experienced animalsSpecific stressorsChild maltreatmentSubstance useMesolimbic dopamineStress exposureStress regulationAddictionChronic stressCentral noradrenergic systemNoradrenergic systemButyric acid pathway
2007
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li CS, Sinha R. Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction. Neuroscience & Biobehavioral Reviews 2007, 32: 581-597. PMID: 18164058, PMCID: PMC2263143, DOI: 10.1016/j.neubiorev.2007.10.003.Peer-Reviewed Original ResearchMeSH KeywordsBrain MappingCentral Nervous System StimulantsFrontal LobeHumansInhibition, PsychologicalLimbic SystemMotivationNeural PathwaysStress, PsychologicalSubstance-Related DisordersConceptsInhibitory controlPrefrontal activityDrug seekingHabitual drug seekingCognitive inhibitory controlCompulsive drug seekingVentromedial prefrontal regionsFrontal-limbic dysfunctionStress-related cravingAnterior cingulate cortexStress regulationPsychological processesNeural underpinningsSalient stimuliStress processingPrefrontal regionsComponent processesStriatal responsesDrug use behaviorsCingulate cortexNeural systemsPsychostimulant dependenceUse behaviorsNeural pathwaysAddiction
2001
How does stress increase risk of drug abuse and relapse?
Sinha R. How does stress increase risk of drug abuse and relapse? Psychopharmacology 2001, 158: 343-359. PMID: 11797055, DOI: 10.1007/s002130100917.Peer-Reviewed Original ResearchConceptsDrug abuseSubstance abuseMost major theoriesHuman laboratory studiesField of addictionDrug seekingDrug useTreatment developmentMajor theoriesAbuse altersStress exposureVulnerable individualsHuman researchAbuseAddictsEmpirical evidencePreclinical evidenceClinical observationsRelapseAnimal studiesPreclinical researchSeekingGreater understandingAddictionResearch
2000
Motivation to change substance use among offenders of domestic violence
Easton C, Swan S, Sinha R. Motivation to change substance use among offenders of domestic violence. Journal Of Substance Use And Addiction Treatment 2000, 19: 1-5. PMID: 10867294, DOI: 10.1016/s0740-5472(99)00098-7.Peer-Reviewed Original ResearchPrevalence of family violence in clients entering substance abuse treatment
Easton C, Swan S, Sinha R. Prevalence of family violence in clients entering substance abuse treatment. Journal Of Substance Use And Addiction Treatment 2000, 18: 23-28. PMID: 10636603, DOI: 10.1016/s0740-5472(99)00019-7.Peer-Reviewed Original ResearchConceptsSubstance-using clientsIndividual therapy sessionsChildhood traumaFamily violenceAdult victimsTherapy sessionsPhysical violenceHigher scoresSubstance abuse treatmentSubstance-related problemsMichigan Alcoholism Screening TestPositive urine screenChildhood abuseAbuse treatmentChildhood victimsSubstance abusersDepression Inventory scoresAlcoholism Screening TestBeck Depression Inventory scoresFamily historyInventory scoresCocaine useVictimsDomestic violencePerpetrators
1990
Relationships between Neuropsychological Test Performance and Event‐Related Potentials in Alcoholic and Nonalcoholic Samples
Parsons O, Sinha R, Williams H. Relationships between Neuropsychological Test Performance and Event‐Related Potentials in Alcoholic and Nonalcoholic Samples. Alcohol Clinical And Experimental Research 1990, 14: 746-755. PMID: 2264605, DOI: 10.1111/j.1530-0277.1990.tb01239.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismArousalCerebral CortexElectroencephalographyEthanolEvoked PotentialsFemaleHumansMaleNeurocognitive DisordersNeuropsychological TestsSubstance-Related DisordersConceptsEvent-related potentialsNeuropsychological test performanceTest performanceEvent-related potential taskPerceptual-motor testsFamily history positive alcoholicsERP differencesMiddle-aged alcoholicsERP measuresERP responsesP3 amplitudeNeuropsychological testsP3 latencyERP variablesPM testNP measuresPeer controlsNP performanceFemale alcoholicsSober alcoholicsNonalcoholic samplesMale alcoholicsPotential tasksMental disordersNP test