1997
Local urokinase delivery with the Channel balloon: Device safety, pharmacokinetics of intracoronary drug delivery, and efficacy of thrombolysis
Mitchel J, Barry J, Bow L, Alberghini T, Abbas S, McKay R. Local urokinase delivery with the Channel balloon: Device safety, pharmacokinetics of intracoronary drug delivery, and efficacy of thrombolysis. Catheterization And Cardiovascular Interventions 1997, 41: 254-260. PMID: 9213023, DOI: 10.1002/(sici)1097-0304(199707)41:3<254::aid-ccd5>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAnimalsCell DivisionDrug Delivery SystemsEquipment DesignEquipment SafetyFeasibility StudiesFemaleFibrinolytic AgentsIliac ArteryMaleMuscle, Smooth, VascularProliferating Cell Nuclear AntigenSwineThrombolytic TherapyTreatment OutcomeTunica MediaUrokinase-Type Plasminogen ActivatorConceptsLocal urokinase deliveryConventional balloon angioplastyBalloon angioplastyDrug infusionDrug depositionPorcine modelLocal drug delivery catheterLocal deliveryDrug delivery catheterEfficacy of thrombolysisComparative histologic studyCatheter infusionBalloon useVessel traumaCoronary arteryLocal infusionThrombolytic techniquesIntracoronary useHistologic changesBalloon inflationIntramural depositionHistologic studyArtery ratioCoronary vesselsAnesthetized swineLocal delivery of c‐myb antisense oligonucleotides during balloon angioplasty
Azrin M, Mitchel J, Bow L, Pedersen C, Cartun R, Aretz T, Waters D, McKay R. Local delivery of c‐myb antisense oligonucleotides during balloon angioplasty. Catheterization And Cardiovascular Interventions 1997, 41: 232-240. PMID: 9213020, DOI: 10.1002/(sici)1097-0304(199707)41:3<232::aid-ccd2>3.0.co;2-7.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAnimalsAutoradiographyCell DivisionCoronary DiseaseCoronary VesselsDrug Delivery SystemsFeasibility StudiesFemaleLymphocyte ActivationMiceMicroscopy, FluorescenceMuscle, Smooth, VascularOligonucleotides, AntisenseProliferating Cell Nuclear AntigenProto-Oncogene ProteinsProto-Oncogene Proteins c-mybSwineTrans-ActivatorsConceptsSmooth muscle cell proliferationMuscle cell proliferationIntraluminal deliveryBalloon angioplastyCell proliferationLess cellular proliferationQuantitative immunohistochemical stainingCatheter-based systemC-MybC-myb antisenseCell nuclear antigenArterial injuryPeripheral arteriesLymphocyte proliferationContralateral vesselCarotid arteryImmunohistochemical stainingAngioplastyArterial mediaArterial segmentsNuclear antigenLocal deliveryCellular proliferationArteryProliferationLocalized delivery of heparin to angioplasty sites with iontophoresis
Mitchel J, Azrin M, Fram D, Bow L, McKay R. Localized delivery of heparin to angioplasty sites with iontophoresis. Catheterization And Cardiovascular Interventions 1997, 41: 315-323. PMID: 9213031, DOI: 10.1002/(sici)1097-0304(199707)41:3<315::aid-ccd13>3.0.co;2-m.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAngioplasty, Balloon, CoronaryAnimalsAnticoagulantsAortaCoronary VesselsDose-Response Relationship, DrugDrug Delivery SystemsElastic TissueEquipment DesignHeparinIontophoresisMaleMuscle, Smooth, VascularPlatelet AggregationRatsRats, Sprague-DawleySwineTunica IntimaTunica MediaConceptsPorcine coronary arteriesBalloon injuryPlatelet depositionDrug depositionCoronary arteryIontophoretic catheterHeparin deliveryControl vesselsLocal deliveryContralateral control vesselsIontophoresis of salineEarly platelet depositionFluorescent heparinBalloon inflation pressureInternal elastic laminaIntramural localizationAngioplasty siteBalloon angioplastyCoronary studiesHemodynamic sequelaeIliac vesselsIntramural depositionImmediate drug deliveryPlatelet studiesArtery
1996
Functional and structural alterations with 24-hour myocardial hibernation and recovery after reperfusion. A pig model of myocardial hibernation.
Chen C, Chen L, Fallon J, Ma L, Li L, Bow L, Knibbs D, McKay R, Gillam L, Waters D. Functional and structural alterations with 24-hour myocardial hibernation and recovery after reperfusion. A pig model of myocardial hibernation. Circulation 1996, 94: 507-16. PMID: 8759096, DOI: 10.1161/01.cir.94.3.507.Peer-Reviewed Original ResearchConceptsRegional coronary flowMyocardial hibernationCoronary flowRegional wall thickeningWall thickeningPig modelShort-term myocardial hibernationRegional lactate productionRate-pressure productCoronary artery stenosisCoronary flow reductionAcute myocardial ischemiaUltrastructural changesLactate productionLocal metabolic changesModerate flow reductionShort-term hibernationRegional oxygen consumptionFlow reductionMyocardium undergoesLAD stenosisArtery stenosisLAD flowMyocardial infarctionStructural alterations
1995
Enhanced intracoronary thrombolysis with urokinase using a novel, local drug delivery system. In vitro, in vivo, and clinical studies.
Mitchel J, Fram D, Palme D, Foster R, Hirst J, Azrin M, Bow L, Eldin A, Waters D, McKay R. Enhanced intracoronary thrombolysis with urokinase using a novel, local drug delivery system. In vitro, in vivo, and clinical studies. Circulation 1995, 91: 785-93. PMID: 7828307, DOI: 10.1161/01.cir.91.3.785.Peer-Reviewed Original ResearchConceptsDispatch catheterLocal infusionEnd-hole catheterU urokinaseCatheter infusionIntracoronary thrombusAngioplasty siteUrokinase administrationLocal drug delivery systemIntracoronary thrombolysisUrokinase infusionBalloon angioplastySystemic bolusIntramural depositionNew local drug delivery systemDistal coronary flowLocal urokinase deliveryLocal urokinase infusionThrombus-containing stenosesConventional balloon angioplastyInfusion of urokinaseInfusion of salinePorcine coronary arteriesSystemic fibrinolytic stateCardiac catheterization laboratory
1994
Inhibition of platelet deposition and lysis of intracoronary thrombus during balloon angioplasty using urokinase-coated hydrogel balloons.
Mitchel J, Azrin M, Fram D, Hong M, Wong S, Barry J, Bow L, Curley T, Kiernan F, Waters D. Inhibition of platelet deposition and lysis of intracoronary thrombus during balloon angioplasty using urokinase-coated hydrogel balloons. Circulation 1994, 90: 1979-1988. PMID: 7923688, DOI: 10.1161/01.cir.90.4.1979.Peer-Reviewed Original ResearchConceptsLocal urokinase deliveryVivo balloon angioplastyIntracoronary thrombusBalloon angioplastyPlatelet depositionThrombotic closureDistal embolizationAngioplasty siteAbrupt closureArterial wallHydrogel balloonContralateral control arteriesContralateral control vesselsIntramural drug deliveryVivo studiesConventional balloon angioplastyNew Zealand rabbitsU urokinaseConventional angioplastyBalloon dilatationClinical efficacyReflow phenomenonIliac arteryBlood exposureControl arteriesDecreased platelet deposition and smooth muscle cell proliferation after intramural heparin delivery with hydrogel-coated balloons.
Azrin M, Mitchel J, Fram D, Pedersen C, Cartun R, Barry J, Bow L, Waters D, McKay R. Decreased platelet deposition and smooth muscle cell proliferation after intramural heparin delivery with hydrogel-coated balloons. Circulation 1994, 90: 433-441. PMID: 8026030, DOI: 10.1161/01.cir.90.1.433.Peer-Reviewed Original ResearchConceptsSmooth muscle cell proliferationMuscle cell proliferationBalloon angioplastyHeparin deliveryPlatelet depositionBalloon dilatationCell proliferationBalloon surfaceMedial smooth muscle cell proliferationLocal heparin deliveryTime of angioplastyVivo balloon angioplastyHydrogel balloonLocal intramural deliveryPorcine peripheral arteriesCell nuclear antigenIntraluminal deliveryAngioplasty injuryBalloon injuryPeripheral arteriesIntramural depositionContralateral vesselIntact circulationImmunohistochemical stainingAngioplasty