Kuldeepkumar Gupta, PhD
Associate Research ScientistCards
About
Research
Publications
2023
Chapter 3 Signaling nucleotides in bacteria
Gupta K, Arora G, Sajid A. Chapter 3 Signaling nucleotides in bacteria. 2023, 35-48. DOI: 10.1016/b978-0-323-91806-0.00013-8.ChaptersFunctions of nucleotidesDifferent signaling modulesBacterial physiologySignaling modulesSuccessful speciesMajor morphological changesSecond messengerProtein synthesisEnvironmental stimuliNucleotidesBacteriaUnfavorable conditionsMorphological changesTranscriptionSpeciesMessengerDifferent signalsPhysiologyReplicationMetabolismGMPResponse
2022
An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria
Gupta K, Gwin C, Rahlwes K, Biegas K, Wang C, Park J, Liu J, Swarts B, Morita Y, Rego E. An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria. ELife 2022, 11: e80395. PMID: 36346214, PMCID: PMC9678360, DOI: 10.7554/elife.80395.Peer-Reviewed Original ResearchConceptsPeriplasmic proteinsPolar growthNew cell wall materialOld poleQuantitative time-lapse imagingAsymmetric polar growthCell wall synthesisCell envelope compositionCell wall materialTime-lapse imagingCellular asymmetryEssential proteinsBacterial geneticsEssential transporterSingle geneWall synthesisLipid traffickingPopulation of cellsPlasma membraneTMM transportUnknown functionBroad functionsMycolic acidsTrehalose monomycolateEnvelope compositionCell Wall Damage Reveals Spatial Flexibility in Peptidoglycan Synthesis and a Nonredundant Role for RodA in Mycobacteria
Melzer E, Kado T, García-Heredia A, Gupta K, Meniche X, Morita Y, Sassetti C, Rego E, Siegrist M. Cell Wall Damage Reveals Spatial Flexibility in Peptidoglycan Synthesis and a Nonredundant Role for RodA in Mycobacteria. Journal Of Bacteriology 2022, 204: e00540-21. PMID: 35543537, PMCID: PMC9210966, DOI: 10.1128/jb.00540-21.Peer-Reviewed Original ResearchConceptsPenicillin binding proteinsCell wall damagePeptidoglycan synthesisPeptidoglycan assemblyClass A Penicillin-Binding ProteinsNascent cell wallCell wall integrityCell wall assemblyCell-wall peptidoglycanCell wall synthesisRod-shaped bacteriaMycobacterium smegmatisPolar growthInternal turgorModel organismsMreB homologsNew inhibition strategyRod complexWall synthesisWall peptidoglycanWall integrityAnimal pathogensCell wallPathway functionSubcellular distribution
2021
Stringent Response in Mycobacteria: From Biology to Therapeutic Potential
Gupta KR, Arora G, Mattoo A, Sajid A. Stringent Response in Mycobacteria: From Biology to Therapeutic Potential. Pathogens 2021, 10: 1417. PMID: 34832573, PMCID: PMC8622095, DOI: 10.3390/pathogens10111417.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements