2011
Genetic associations with performance on a behavioral measure of distress intolerance
Amstadter AB, Daughters SB, MacPherson L, Reynolds EK, Danielson CK, Wang F, Potenza MN, Gelernter J, Lejuez CW. Genetic associations with performance on a behavioral measure of distress intolerance. Journal Of Psychiatric Research 2011, 46: 87-94. PMID: 22024485, PMCID: PMC3687355, DOI: 10.1016/j.jpsychires.2011.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCatechol O-MethyltransferaseChildChi-Square DistributionDistrict of ColumbiaFemaleGene FrequencyGenetic Association StudiesGenotypeHumansLongitudinal StudiesMaleMood DisordersPolymorphism, Single NucleotidePsychiatric Status Rating ScalesRegression AnalysisRisk-TakingSerotonin Plasma Membrane Transport ProteinsConceptsEmotion regulation difficultiesDistress intoleranceBehavioral measuresPoor psychological functioningAdolescent risk behaviorsDistress tolerancePsychological functioningLarger longitudinal studyVal allele carriersYear old youthMet homozygotesEmotional abuseBehavioral indicatorsBehavioral assessmentLongitudinal studyGenetic influencesCandidate genetic polymorphismsTaskYouthDistressExploratory analysisRisk behaviorsEmpirical evidencePrior studiesDifficulties
2009
Modification of the Association Between Serotonin Transporter Genotype and Risk of Posttraumatic Stress Disorder in Adults by County-Level Social Environment
Koenen KC, Aiello AE, Bakshis E, Amstadter AB, Ruggiero KJ, Acierno R, Kilpatrick DG, Gelernter J, Galea S. Modification of the Association Between Serotonin Transporter Genotype and Risk of Posttraumatic Stress Disorder in Adults by County-Level Social Environment. American Journal Of Epidemiology 2009, 169: 704-711. PMID: 19228812, PMCID: PMC2727213, DOI: 10.1093/aje/kwn397.Peer-Reviewed Original Research
2006
Apolipoprotein E ɛ4 Allele Increases Risk for Psychotic Symptoms in Alzheimer's Disease
Zdanys KF, Kleiman TG, MacAvoy MG, Black BT, Rightmer TE, Grey M, Garman KS, Tampi RR, Gelernter J, van Dyck CH. Apolipoprotein E ɛ4 Allele Increases Risk for Psychotic Symptoms in Alzheimer's Disease. Neuropsychopharmacology 2006, 32: 171-179. PMID: 16841077, DOI: 10.1038/sj.npp.1301148.Peer-Reviewed Original ResearchConceptsAD patientsPsychotic symptomsAlzheimer's diseaseBehavioral symptomsNeuropsychiatric InventoryApolipoprotein EMultiple logistic regression modelSporadic Alzheimer's diseaseGenetic risk factorsSevere-stage Alzheimer's diseaseLogistic regression modelsDifferent risk profilesDementia progressesRisk factorsIncrease riskBehavioral disturbancesPatientsDisease severitySymptomsSignificant psychosisRisk profileGreater riskApoEExploratory analysisDiseaseBrain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children
Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children. Biological Psychiatry 2006, 59: 673-680. PMID: 16458264, DOI: 10.1016/j.biopsych.2005.10.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrain-Derived Neurotrophic FactorCase-Control StudiesChildChild AbuseChild, PreschoolChi-Square DistributionDepressionDNA Mutational AnalysisEnvironmentFemaleGene FrequencyGenetic VariationGenotypeHumansMaleMethioninePredictive Value of TestsPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSeverity of Illness IndexSocial SupportSurveys and QuestionnairesValineConceptsBrain-derived neurotrophic factor (BDNF) genotypeNeurotrophic factor genotypeSocial supportHigher depression scoresBDNF genotypeProportion scoreBDNF geneProtective effectDepression scoresComparison subjectsPsychiatric symptomatologyModerate riskEnvironmental modifiersDepressionFactor genotypeChildrenDNA specimensStandard research instrumentsShort alleleRiskMaltreatment historyCurrent dataScoresAncestry informative markersChild abuse
2005
COMT Polymorphisms and Anxiety-Related Personality Traits
Stein MB, Fallin MD, Schork NJ, Gelernter J. COMT Polymorphisms and Anxiety-Related Personality Traits. Neuropsychopharmacology 2005, 30: 2092-2102. PMID: 15956988, DOI: 10.1038/sj.npp.1300787.Peer-Reviewed Original ResearchAdolescentAdultAnxietyCatechol O-MethyltransferaseChi-Square DistributionConfidence IntervalsDemographyExtraversion, PsychologicalFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMaleMethionineNeurotic DisordersOdds RatioPersonalityPersonality InventoryPolymorphism, GeneticSex FactorsValine
2004
A polymorphism of the β1-adrenergic receptor is associated with low extraversion
Stein MB, Schork NJ, Gelernter J. A polymorphism of the β1-adrenergic receptor is associated with low extraversion. Biological Psychiatry 2004, 56: 217-224. PMID: 15312808, DOI: 10.1016/j.biopsych.2004.05.020.Peer-Reviewed Original ResearchAdolescentAdultArginineChi-Square DistributionCluster AnalysisEthnicityExtraversion, PsychologicalFemaleGene FrequencyGlycineHumansMalePersonality InventoryPhenotypePolymorphism, GeneticPsychiatric Status Rating ScalesReceptors, Adrenergic, beta-1Regression AnalysisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSerineSex CharacteristicsSurveys and QuestionnairesGenomic regions controlling corticosterone levels in rats
Potenza MN, Brodkin ES, Joe B, Luo X, Remmers EF, Wilder RL, Nestler EJ, Gelernter J. Genomic regions controlling corticosterone levels in rats. Biological Psychiatry 2004, 55: 634-641. PMID: 15013833, DOI: 10.1016/j.biopsych.2003.11.005.Peer-Reviewed Original ResearchConceptsGenomic regionsQuantitative trait locus (QTL) analysisGenome-wide levelSpecific genomic regionsUnderstanding of susceptibilitySignificant QTLGenomic backgroundChromosome 4Locus analysisF2 progenyGenetic differencesSuggestive significanceDisease susceptibilityQTLFirst identificationCongenic animalsDeoxyribonucleic acidGenetic factorsProgenyIdentificationRegionSusceptibilityLevelsNOTCH4 gene haplotype is associated with schizophrenia in African Americans
Luo X, Klempan TA, Lappalainen J, Rosenheck RA, Charney DS, Erdos J, van Kammen DP, Kranzler HR, Kennedy JL, Gelernter J. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Biological Psychiatry 2004, 55: 112-117. PMID: 14732589, DOI: 10.1016/s0006-3223(03)00588-2.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanChi-Square DistributionCysteineDiagnostic and Statistical Manual of Mental DisordersFemaleGene FrequencyGenotypeGlycineHaplotypesHumansLinkage DisequilibriumMalePolymerase Chain ReactionPolymorphism, Single NucleotideProto-Oncogene ProteinsReceptor, Notch4Receptors, Cell SurfaceReceptors, NotchSchizophreniaThreonineConceptsHealthy control subjectsControl subjectsSingle nucleotide polymorphismsExact testSchizophrenia patientsAfrican AmericansFisher's exact testNOTCH4 locusChi-square testComparison of alleleEuropean-American subjectsPositive linkage disequilibriumAA subjectsPatientsSchizophreniaSpecific markersHaplotype frequenciesT associatesLinkage disequilibriumEA subjectsNOTCH4 geneSubjectsGene haplotypesAmerican subjectsNucleotide polymorphisms
2000
Genetic polymorphism at the CLOCK gene locus and major depression
Desan P, Oren D, Malison R, Price L, Rosenbaum J, Smoller J, Charney D, Gelernter J. Genetic polymorphism at the CLOCK gene locus and major depression. American Journal Of Medical Genetics 2000, 96: 418-421. PMID: 10898925, DOI: 10.1002/1096-8628(20000612)96:3<418::aid-ajmg34>3.0.co;2-s.Peer-Reviewed Original Research
1999
No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans
Gelernter J, Kranzler H, Satel S. No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans. Biological Psychiatry 1999, 45: 340-345. PMID: 10023512, DOI: 10.1016/s0006-3223(97)00537-4.Peer-Reviewed Original ResearchAllelesBehavior, AddictiveBlack PeopleCase-Control StudiesChi-Square DistributionCocaine-Related DisordersComputer SimulationFemaleGene DosageGenetic MarkersGenetic Predisposition to DiseaseHaplotypesHumansLinkage DisequilibriumMalePolymorphism, Restriction Fragment LengthReceptors, Dopamine D2Severity of Illness IndexWhite People