Jessica Magid-Bernstein, MD, PhD
Assistant Professor of NeurologyDownloadHi-Res Photo
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Appointments
Neurology
Primary
About
Titles
Assistant Professor of Neurology
Biography
Dr. Magid-Bernstein completed her MD and PhD with a focus in immunology at Rutgers University – New Jersey Medical School in Newark, NJ in 2015. She then went on to complete her medical internship and residency training in Neurology at New York Presbyterian – Columbia University Medical Center, followed by a fellowship in Neurocritical Care at New York Presbyterian – Columbia University Medical Center & Weill Cornell Medicine before joining the Yale Department of Neurology Division of Neurocritical Care and Emergency Neurology in 2021.
Dr. Magid-Bernstein is dedicated to taking care of complex neurocritically ill patients during her clinical time in the NeuroICU at Yale. When she is not on clinical service, she is developing a research career focused on understanding the role that inflammation plays in outcomes following intracerebral hemorrhage and subarachnoid hemorrhage.
Last Updated on October 02, 2023.
Appointments
Neurology
Assistant ProfessorPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Magid-Bernstein Lab
- Neurocritical Care & Emergency Surgery
- Neurology
- Yale Medicine
Education & Training
- Fellow
- NY Presbyterian - Columbia University Medical Center/Weill Cornell Medicine (2021)
- Resident
- NY Presbyterian - Columbia University Medical Center (2019)
- Intern
- NY Presbyterian - Columbia University Medical Center (2016)
- MD
- Rutgers University - New Jersey Medical School (2015)
- PhD
- University of Medicine and Dentistry of NJ - New Jersey Medical School (2013)
- BA
- Haverford College (2006)
Research
Overview
Medical Research Interests
Cerebral Intraventricular Hemorrhage; Inflammation; Intracranial Hemorrhages; Subarachnoid Hemorrhage
ORCID
0000-0001-6506-6017- View Lab Website
Magid-Bernstein lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jessica Magid-Bernstein's published research.
Publications Timeline
A big-picture view of Jessica Magid-Bernstein's research output by year.
Research Interests
Research topics Jessica Magid-Bernstein is interested in exploring.
Kevin Sheth, MD
Emily J. Gilmore, MD, FNCS, FACNS
Charles Matouk, MD
Nils Petersen, MD, PhD, MSc
Guido J. Falcone, MD, ScD, MPH
Lauren Hachmann Sansing, MD, MS, FAHA, FANA
29Publications
653Citations
Subarachnoid Hemorrhage
Publications
Featured Publications
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circulation Research 2022, 130: 1204-1229. PMID: 35420918, PMCID: PMC10032582, DOI: 10.1161/circresaha.121.319949.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMechanism of injuryIntracerebral hemorrhageUltra-early hemostatic therapyInflammatory brain injuryCurrent treatment strategiesIron-induced injuryAnticoagulant useHemostatic therapyHemorrhagic strokeHypertension managementICH therapySurgical managementHigh morbidityPrimary preventionFunctional outcomeICH managementBrain injuryClinical trialsTreatment strategiesPrognostic biomarkerDevastating formDisease pathobiologyInjuryInvasive surgeryOxidative stressImpacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage
Magid-Bernstein J, Beaman CB, Carvalho-Poyraz F, Boehme A, Hod EA, Francis RO, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Roh D. Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage. Blood 2021, 137: 2699-2703. PMID: 33649761, PMCID: PMC9635530, DOI: 10.1182/blood.2020008381.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsABO-incompatible platelet transfusionsIntracerebral hemorrhagePlatelet transfusionsPlatelet recoveryABO-compatible transfusionsSingle-center cohortOdds of mortalityABO-incompatible transfusionLow platelet recoveryNeurological outcomeOngoing bleedingABO compatibilityICH outcomeMedication effectsTransfusionPoor mRSPatientsHemorrhageOutcomesUnderlying mechanismFurther investigationBleedingCohortMortalityRecoveryCerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials
Magid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone G, Sheth K, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley D, Kamel H, Ziai WC, Murthy SB. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Neurology 2021, 98: e1013-e1020. PMID: 34937780, PMCID: PMC8967392, DOI: 10.1212/wnl.0000000000013247.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSmaller ICH volumeCerebral microbleedsSmall vessel diseaseIntracerebral hemorrhageHematoma expansionHematoma characteristicsICH volumeVessel diseaseNumber of CMBsSmaller baseline hematoma volumesUnderlying small vessel diseasePresence of CMBsCerebral small vessel diseaseAdmission ICH volumeMISTIE III trialPresence of microbleedsClass II evidencePhase 3 trialSeverity of leukoaraiosisPrimary intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataBrain MRI scansLogistic regression modelsAntihypertensive treatment
2025
Do the Benefits of Blood Pressure Control in ICH Outweigh the Risks?
Magid-Bernstein J, Murthy S. Do the Benefits of Blood Pressure Control in ICH Outweigh the Risks? JAMA Neurology 2025, 82: 541-542. PMID: 40257789, DOI: 10.1001/jamaneurol.2025.0238.Peer-Reviewed Original ResearchAltmetricIntegrated Genomic and Proteomic Drug Target Discovery for Vascular Dementia and Alzheimer’s Disease (P3-3.015)
Huo S, Clocchiatti-Tuozzo S, Magid-Bernstein J, Sharma R, Rangaraju S, Sansing L, Sheth K, Rivier C, Falcone G. Integrated Genomic and Proteomic Drug Target Discovery for Vascular Dementia and Alzheimer’s Disease (P3-3.015). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000211466.Peer-Reviewed Original ResearchAltmetricAnalyzing Nimodipine-Associated Hemodynamic and Electrophysiologic Changes and Functional Outcomes in Aneurysmal Subarachnoid Hemorrhage (P5-13.018)
Jayasundara S, Choi R, Rapuano A, Chen Y, Top I, Olexa M, Maarek R, Yan J, Estrella D, Magid-Bernstein J, Amllay A, O’Keefe L, Hebert R, Bahrassa F, Sheth K, Beekman R, Gilmore E, Matouk C, Kim J, Petersen N. Analyzing Nimodipine-Associated Hemodynamic and Electrophysiologic Changes and Functional Outcomes in Aneurysmal Subarachnoid Hemorrhage (P5-13.018). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000211312.Peer-Reviewed Original ResearchAssessing the Effects of Cerebral Autoregulation and Neurophysiologic Parameters on Outcomes in aSAH (P2-13.016)
Estrella D, Jayasundara S, Maarek R, Choi R, Chen Y, Top I, Olexa M, Amllay A, Rapuano A, Magid-Bernstein J, Hebert R, Matouk C, Sheth K, Bahrassa F, Beekman R, O’Keefe L, Gilmore E, Petersen N, Kim J. Assessing the Effects of Cerebral Autoregulation and Neurophysiologic Parameters on Outcomes in aSAH (P2-13.016). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000211339.Peer-Reviewed Original ResearchAnalyzing the Neurophysiologic Effects of IA Verapamil During Angiographic Treatment of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage (P11-7.005)
Maarek R, Stoehr K, Jayasundara S, Estrella D, Choi R, Rapuano A, Koo A, Chen Y, Magid-Bernstein J, O'Keefe L, Hebert R, Bahrassa F, Westover B, Matouk C, Petersen N, Gilmore E, Kim J. Analyzing the Neurophysiologic Effects of IA Verapamil During Angiographic Treatment of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage (P11-7.005). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000212147.Peer-Reviewed Original Research
2024
Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage
Rivier C, Renedo D, Marini S, Magid‐Bernstein J, de Havenon A, Rosand J, Hanley D, Ziai W, Mayer S, Woo D, Sansing L, Sheth K, Anderson C, Falcone G. Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage. Annals Of Neurology 2024, 97: 232-241. PMID: 39499118, DOI: 10.1002/ana.27123.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRisk of hematoma expansionHighest risk of hematoma expansionRisk of poor outcomesIntracerebral hemorrhageHematoma expansionHigh riskMale sexPoor outcomeOutcome of spontaneous intracerebral hemorrhageClinical characteristics of patientsStudies of intracerebral hemorrhageNon-traumatic intracerebral hemorrhageIndividual patient data meta-analysisPatient data meta-analysisSpontaneous intracerebral hemorrhageSingle-center studyIntracerebral hemorrhage patientsHigh risk of expansionCharacteristics of patientsIntracerebral hemorrhage severityPoor functional outcomeRandomized clinical trialsData meta-analysisHemorrhage volumeClinical characteristicsExploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004)
Olexa M, Begunova Y, Gilmore E, Kim J, Herman A, Beekman R, Magid-Bernstein J, Matouk C, Sheth K, Miller E, Gutierrez S, De Havenon A, Sansing L, Petersen N. Exploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205692.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
HIC ID2000031665RolePrincipal InvestigatorPrimary Completion Date12/01/2025Recruiting ParticipantsGenderBothAge18+ yearsBrain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)
HIC ID2000024956RoleSub InvestigatorPrimary Completion Date07/01/2023Recruiting ParticipantsGenderBothAge14+ yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
HIC ID2000026409RoleSub InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
Activities
activity BMC Neurology
2020 - PresentJournal ServiceRevieweractivity Hypertension
2020 - PresentJournal ServiceRevieweractivity Neurohospitalst
2020 - PresentJournal ServiceRevieweractivity Neurocritical Care
2021 - PresentJournal ServiceRevieweractivity Journal of the American Heart Association
2020 - PresentJournal ServiceReviewer
Honors
honor American Neurological Association Emerging Scholar Award candidate
09/13/2024National AwardAmerican Neurological AssociationDetailsUnited Stateshonor American Neurologic Association Annual Meeting travel grant
10/22/2022National AwardAmerican Neurological Associationhonor American Neurological Association Emerging Scholar Award candidate
10/22/2022National AwardAmerican Neurological Associationhonor Neurocritical Care Society travel grant
09/22/2020International AwardNeurocritical Care SocietyDetailsUnited Stateshonor AOA Honor Medical Society member
08/01/2015National AwardDetailsUnited States
Clinical Care
Overview
Jessica Magid-Bernstein, MD, PhD, completed her MD and PhD with a focus in immunology at Rutgers University – New Jersey Medical School in Newark, NJ, in 2015. She then went on to complete her medical internship and residency training in Neurology at New York Presbyterian – Columbia University Medical Center, followed by a fellowship in Neurocritical Care at New York Presbyterian – Columbia University Medical Center & Weill Cornell Medicine before joining the Yale Department of Neurology Division of Neurocritical Care and Emergency Neurology in 2021.
Dr. Magid-Bernstein is dedicated to taking care of complex neurocritically ill patients during her clinical time in the NeuroICU at Yale. When she is not on clinical service, she is developing a research career focused on understanding the role that inflammation plays in outcomes following intracerebral hemorrhage and subarachnoid hemorrhage.
Clinical Specialties
Neurology; Neurocritical Care
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Yale Neurology
Academic Office
100 York Street, Ste Suite 1N
New Haven, CT 06511