2019
What does immunology have to do with brain development and neuropsychiatric disorders?
Leckman J, Alvarenga P, Ravagnani B, Johnson I. What does immunology have to do with brain development and neuropsychiatric disorders? Revista De Medicina 2019, 98: 241-253. DOI: 10.11606/issn.1679-9836.v98i4p241-253.Peer-Reviewed Original ResearchImmune systemNormal brain developmentBrain developmentNeuropsychiatric disordersNeural circuitsGut-brain axisRelevant review articlesAutism spectrum disorderObsessive-compulsive disorderBody of evidenceImmune cellsMood disordersValid biomarkersSubset of individualsTourette syndromeNovel interventionsNeurodegenerative disordersPersonalized approachLiterature searchDisordersMultiple biological systemsPathobiologyNeural developmentTraditional literature searchIndividual microbiomes
2017
Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders
Guloksuz SA, Abali O, Cetin E, Gazioglu S, Deniz G, Yildirim A, Kawikova I, Guloksuz S, Leckman JF. Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders. Brazilian Journal Of Psychiatry 2017, 39: 195-200. PMID: 28099628, PMCID: PMC7111377, DOI: 10.1590/1516-4446-2015-1843.Peer-Reviewed Original ResearchConceptsTumor necrosis factor alphaNecrosis factor alphaS100B concentrationsPlasma concentrationsFactor alphaChildhood Autism Rating ScaleS100 calcium-binding protein BCalcium-binding protein BElevated plasma concentrationsTNF-α concentrationsAutism spectrum disorderIL-17AIL-10Cytokine concentrationsInflammatory cytokinesIL-6Peripheral concentrationsHealthy childrenIL-4Plasma levelsSpectrum disorderImmune functionInterferon gammaImmune systemS100B
2016
Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism
Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA. Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism. Scientific Reports 2016, 6: 35054. PMID: 27845765, PMCID: PMC5109935, DOI: 10.1038/srep35054.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderIntranasal oxytocinSocial motivationSocial perceptionSocial-emotional informationFunctional magnetic resonance imagingPlacebo-controlled crossover designBiological motionSocial stimuliAngry voicesSocial deficitsSpectrum disorderOT administrationMesolimbic reward pathwayBehavioral treatmentBrain rewardReduced connectivityBrain regionsReward pathwayCortical sitesRewardPerceptionMotivationOxytocinBrain sites
2014
Gender and Injuries Predict Stimulant Medication Use
Dalsgaard S, Leckman JF, Nielsen HS, Simonsen M. Gender and Injuries Predict Stimulant Medication Use. Journal Of Child And Adolescent Psychopharmacology 2014, 24: 253-259. PMID: 24813570, PMCID: PMC4064734, DOI: 10.1089/cap.2013.0101.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild Development Disorders, PervasiveCraniocerebral TraumaFemaleFollow-Up StudiesHumansMaleMental DisordersPractice Patterns, Physicians'Prospective StudiesSeverity of Illness IndexSex FactorsWounds and InjuriesConceptsAttention-deficit/hyperactivity disorderStimulant treatmentNumber of injuriesADHD medicationPsychiatric disordersStimulant medicationAutism spectrum disorderFirst prospective studyGroup of patientsPopulation-based studyYears of ageEarly life predictorsStimulant medication useMedication useGroup of childrenProspective studyPharmacological treatmentHead injuryNational cohortDrug prescriptionsMale genderPsychiatric diagnosisMedicationsNational registersInjury
2013
Oxytocin enhances brain function in children with autism
Gordon I, Vander Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSuperior temporal sulcusTemporal sulcusOrbitofrontal cortexLeft superior temporal sulcusMiddle frontal gyrusMedial prefrontal cortexRight orbitofrontal cortexSocial attunementSocial judgmentsMeaningful stimuliFrontal gyrusSpectrum disorderBrain activityPrefrontal cortexRight amygdalaSocial functioningFunctional MRIPremotor cortexHedonic evaluationBrain functionJudgmentsCortexChildrenOxytocin
2009
Autism spectrum and obsessive–compulsive disorders: OC behaviors, phenotypes and genetics
Jacob S, Landeros‐Weisenberger A, Leckman JF. Autism spectrum and obsessive–compulsive disorders: OC behaviors, phenotypes and genetics. Autism Research 2009, 2: 293-311. PMID: 20029829, PMCID: PMC3974607, DOI: 10.1002/aur.108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChildChild Development Disorders, PervasiveChild, PreschoolComorbidityDiagnosis, DifferentialDisease Models, AnimalDiseases in TwinsGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansInfantIntellectual DisabilityInterview, PsychologicalNeuropsychological TestsObsessive-Compulsive DisorderPhenotypeQuantitative Trait, HeritableStereotyped BehaviorConceptsAutism spectrum disorderObsessive-compulsive behaviorObsessive-compulsive disorderNovel treatment interventionsFamily genetic studiesAutism spectrumGeneralist genesOC behaviorSpectrum disorderRare genetic variantsASD variesHeritable endophenotypeASD phenotypeCandidate gene studiesNovel genomic technologiesNonparametric linkage analysisInnovative statistical approachChronological ageGenetic mechanismsGenomic technologiesTreatment interventionsGenetic analysisGenetic influencesLinkage analysisGene studies