Dissecting the association between gut microbiota, body mass index and specific depressive symptoms: a mediation Mendelian randomisation study
Yu T, Chen C, Yang Y, Wang M, Yang Y, Feng W, Yuan S, Ma X, Li J, Zhang B. Dissecting the association between gut microbiota, body mass index and specific depressive symptoms: a mediation Mendelian randomisation study. General Psychiatry 2024, 37: e101412. PMID: 38975363, PMCID: PMC11227829, DOI: 10.1136/gpsych-2023-101412.Peer-Reviewed Original ResearchActinobacteria phylumGut microbiotaBody mass indexSpecific depressive symptomsDepressive symptomsMendelian randomisationGenome-wide association studiesTwo-sample Mendelian randomisationMass indexDepressed moodAppetite changesMendelian randomisation studiesBifidobacteriaceae familyAssociation studiesActinobacteriaPhylumMR analysisGenusFamily XIMicrobiotaObservational studyMediation analysisClinical practiceGutProtective effectGhrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis
Zhang C, Dong Y, Li S, Li M, Gao Y, Liu Y, Liu X, Zhou C, Li J. Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis. Asia-Pacific Psychiatry 2024, 16: e12552. PMID: 38348641, DOI: 10.1111/appy.12552.Peer-Reviewed Original ResearchConceptsFirst-episode drug-naive MDD patientsMajor depressive disorderHAMD total scoreDrug-naive MDD patientsMDD patientsDepressive symptomsCorticotropin-releasing-hormoneTotal scoreDepressive disorderPathogenesis of major depressive disorderMeasures of depressive symptomsHealthy controlsHypothalamic-pituitary-adrenal axisHamilton Depression ScaleBody mass indexAdrenocorticotropic hormoneHAMD-17Plasma levels of ghrelinGhrelin levelsMediation analysisHAMDPartial correlation analysisDepression ScaleCortisol levelsLevels of ghrelin