Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia
Bai H, Lee JS, Chen E, Wang M, Xing Y, Fahmy TM, Dardik A. Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia. Scientific Reports 2017, 7: 40142. PMID: 28071663, PMCID: PMC5223139, DOI: 10.1038/srep40142.Peer-Reviewed Original ResearchConceptsSite-specific deliveryEDC/NHS chemistryComposite delivery systemNanoparticlesDelivery of rapamycinNHS chemistryDelivery systemCardiovascular implantsNext generationRapamycin deliveryDeliveryPositive endotheliumPatchesTherapeutic agentsNeointimal hyperplasiaPericardial patchCovalent modificationTherapeuticsSmooth muscle cell proliferationSurfaceVenous neointimal hyperplasiaMuscle cell proliferation