Howard Feldman, MD, FRCPC, FAAN (Neurology)
Professor AdjunctAbout
Research
Overview
Medical Research Interests
Dementia; Information Science; Named Groups
ORCID
0000-0002-9258-4538
Research at a Glance
Yale Co-Authors
Frequent collaborators of Howard Feldman's published research.
Publications Timeline
A big-picture view of Howard Feldman's research output by year.
Research Interests
Research topics Howard Feldman is interested in exploring.
James Brewer
Vladimir Coric, MD
54Publications
172Citations
Publications
2025
Translation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study
Lee H, Tzuang M, Chow T, Kang Y, Tee B, Li C, Lam E, Gu Y, Lee S, Ho P, Peavy G, Seo E, Kim K, Tran B, Chae W, Nguyen D, Vo N, Dang D, Spat‐Lemus J, Choi Y, Feldman H, Jun G, Wang L, Yu W, Park V, Study T. Translation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study. Alzheimer's & Dementia 2025, 21: e70311. PMID: 40528300, PMCID: PMC12173839, DOI: 10.1002/alz.70311.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCultural adaptationWorld Health OrganizationPromote health literacyCanadian older adultsAsian cohortCulturally appropriate translationCognitive assessment toolsLanguage backgroundAsian languagesAppropriate translationAssessment of cognitive functionHealth literacyStudy materialQuality healthcareCanadian adultsAlzheimer's diseaseTranslation processTranslation guidelinesOlder adultsSociocultural backgroundTranslation methodologyCanadian populationLanguage versionsAdaptation of toolsAssessment toolIWG and AA Criteria—Where the Differences Matter—Reply
Dubois B, Villain N, Feldman H. IWG and AA Criteria—Where the Differences Matter—Reply. JAMA Neurology 2025, 82: 629-630. PMID: 40257771, DOI: 10.1001/jamaneurol.2025.0772.Peer-Reviewed Original ResearchPrognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease
Qiu Y, Jacobs D, Messer K, Salmon D, Wellington C, Stukas S, Revta C, Brewer J, Léger G, Askew B, Donahue L, Kaplita S, Coric V, Qureshi I, Feldman H. Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease. Alzheimer's Research & Therapy 2025, 17: 97. PMID: 40317057, PMCID: PMC12046789, DOI: 10.1186/s13195-025-01745-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMild to moderate ADADAS-cog11CDR-SBBaseline plasma NfLAlzheimer's diseasePlasma biomarkersMild-to-moderate Alzheimer's diseasePrognostic valueClinical trialsBaseline NfLPlasma NfLPlacebo-controlled trialCortical volumeConcentrations of plasma biomarkersMethodsPost hoc analysisDesign of clinical trialsClinical outcome dataIncreased ventricular volumeTrial participantsVolumetric MRIBaseline concentrationsEarly disease stagesClinical trial designTrial entry criteriaAD trialsEffects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study
Baker L, Pa J, Katula J, Aslanyan V, Salmon D, Jacobs D, Chmelo E, Hodge H, Morrison R, Matthews G, Brewer J, Jung Y, Rissman R, Taylor C, Léger G, Messer K, Evans A, Okonkwo O, Shadyab A, Zou J, Jin S, Thomas R, Zhang J, La Croix A, Cotman C, Feldman H, Group F. Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study. Alzheimer's & Dementia 2025, 21: e14586. PMID: 40271888, PMCID: PMC12019696, DOI: 10.1002/alz.14586.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSedentary older adultsAmnestic mild cognitive impairmentIntensity aerobic trainingMild cognitive impairmentEffects of exerciseRandomized controlled trialsIntervention deliveryAerobic trainingOlder adultsMonths of supervised exerciseCognitive impairmentMultisite randomized controlled trialCognitive trajectoriesLower-intensity exerciseMeasure of global cognitive functionRandomized controlled trials of adultsTests of executive functionIntervention group differencesMeasures of brain healthAssess intervention efficacyGlobal cognitive functionGlobal cognitive compositeMild cognitive impairment groupSupervised exerciseMild memory problemsEffects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI
Shadyab A, Aslanyan V, Jacobs D, Salmon D, Morrison R, Katula J, Jin S, Thomas R, LaCroix A, Pa J, Cotman C, Feldman H, Baker L, Group F. Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI. Alzheimer's & Dementia 2025, 21: e70118. PMID: 40271887, PMCID: PMC12019695, DOI: 10.1002/alz.70118.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsUsual careRandomized controlled trialsAmnestic mild cognitive impairmentOlder adultsMild cognitive impairmentADNI-1Multisite randomized controlled trialNo interventionSedentary older adultsIntensity aerobic trainingAlzheimer's Disease Neuroimaging Initiative 1Moderate-high intensityEffects of exerciseCognitive declineCognitive impairmentFlexibility exercisesExercise armAerobic trainingAD-signature regionsExertion groupCognitive trajectoriesExertionCarePost hoc analysisExerciseComparison of Eligibility Criteria and Baseline Characteristics Between the Patient Populations of evoke and evoke+, Clarity AD and TRAILBLAZER-ALZ-2 (P12-3.018)
Mystkowski P, Feldman H, Scheltens P, Hansson O, Sano M, van der Flier W, Bardtrum L, Johannsen P, Jeppesen R, Leon T, Hansen C, Cummings J. Comparison of Eligibility Criteria and Baseline Characteristics Between the Patient Populations of evoke and evoke+, Clarity AD and TRAILBLAZER-ALZ-2 (P12-3.018). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000211264.Peer-Reviewed Original ResearchConceptsMise à jour des critères diagnostiques de la maladie d’Alzheimer : recommandations du groupe de travail international (IWG)
Villain N, Frisoni G, Feldman H, Dubois B, Group I. Mise à jour des critères diagnostiques de la maladie d’Alzheimer : recommandations du groupe de travail international (IWG). Revue Neurologique 2025, 181: s152. DOI: 10.1016/j.neurol.2025.01.297.Peer-Reviewed Original ResearchBrain health PRO/Santé cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction
Belleville S, Anderson N, Bherer L, Camicioli R, Carrier J, Chan S, Cuesta M, Dang-Vu T, Dwosh E, Fiocco A, Ferland G, Gilbert B, Harris E, Itzhak I, Jarrett P, Kadri M, Laurin D, Liu-Ambrose T, McGibbon C, Middleton L, Miller L, Nygaard H, Montero-Odasso M, Murphy K, Phillips N, Pichora-Fuller M, Robillard J, Smith E, Speechley M, Trigui A, Wittich W, Chertkow H, Feldman H, Aging C. Brain health PRO/Santé cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction. The Journal Of Prevention Of Alzheimer's Disease 2025, 100134. PMID: 40090784, DOI: 10.1016/j.tjpad.2025.100134.Peer-Reviewed Original ResearchAltmetricConceptsOnline educational programOlder adultsDementia riskEducation programsCommunity-dwelling older adultsIncreased risk of dementiaPilot studyBrain healthRisk of dementiaRisk factor reductionAbilities of older adultsCognitively stimulating activitiesModifiable risk factorsRisk profileWeb-based programProtective factorsSelf-report questionnairesDementia literacyIntervention MappingPhysical activityIndividual risk profileParticipant literacyDeterminants of riskLifestyle changesIntake questionnaireUse of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research
Smith E, Phillips N, Feldman H, Borrie M, Ganesh A, Henri-Bhargava A, Desmarais P, Frank A, Badhwar A, Barlow L, Bartha R, Best S, Bethell J, Bhangu J, Black S, Bocti C, Bronskill S, Burhan A, Calon F, Camicioli R, Campbell B, Collins D, Dadar M, DeMarco M, Ducharme S, Duchesne S, Einstein G, Fisk J, Gawryluk J, Grossman L, Ismail Z, Itzhak I, Joshi M, Harrison A, Kröger E, Kumar S, Laforce R, Lanctot K, Lau M, Lee L, Masellis M, Massoud F, Mitchell S, Montero-Odasso M, Barnett K, Nygaard H, Pasternak S, Peters J, Rajah M, Robillard J, Rockwood K, Rosa-Neto P, Seitz D, Soucy J, Trenaman S, Wellington C, Zadem A, Chertkow H, Investigators C. Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research. The Journal Of Prevention Of Alzheimer's Disease 2025, 12: 100068. PMID: 39893139, PMCID: PMC12184013, DOI: 10.1016/j.tjpad.2025.100068.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCanadian healthcare systemStatistically significant group differencesAlzheimer's diseaseMild cognitive impairmentMild dementiaHealthcare systemStage of mild cognitive impairmentQuality evidenceSignificant group differencesMonoclonal antibody therapyTrial publicationsCerebrospinal fluid analysisCognitive impairmentCanadian ConsortiumGroup differencesPositron emission tomographyAntibody therapyImaging abnormalitiesTreatment populationClinical trialsIndividual patientsReview evidenceClinical relevanceTherapyAmyloid-related imaging abnormalitiesTailoring implementation strategies for the healthy actions and lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program: Lessons learned from a survey study
Moukarzel S, Araujo-Menendez C, Galang E, Zlatar Z, Feldman H, Banks S, Group H. Tailoring implementation strategies for the healthy actions and lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program: Lessons learned from a survey study. The Journal Of Prevention Of Alzheimer's Disease 2025, 12: 100053. PMID: 39827004, PMCID: PMC12184062, DOI: 10.1016/j.tjpad.2024.100053.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsModifiable risk factorsNon-HispanicHealthy actionsCross-sectional study SETTINGTailored implementation strategiesDecreased dementia riskProgram participantsAssociated with higher interestSelf-administered surveySelf-rated satisfactionDementia programsDementia riskTailored ImplementationMixed-methods analysisIndependent of ethnicityExploratory factor analysisSociodemographic characteristicsOlder adultsStudy settingThematic analysisLifestyle changesProgram enrollmentIn-personProgram implementationImplementation strategies