2024
Functional and structural effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of auditory verbal hallucinations in schizophrenia: A systematic review
Mehta D, Siddiqui S, Ward H, Steele V, Pearlson G, George T. Functional and structural effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of auditory verbal hallucinations in schizophrenia: A systematic review. Schizophrenia Research 2024, 267: 86-98. PMID: 38531161, PMCID: PMC11531343, DOI: 10.1016/j.schres.2024.03.016.Peer-Reviewed Original ResearchAuditory verbal hallucinationsRepetitive transcranial magnetic stimulationVerbal hallucinationsTranscranial magnetic stimulationTreatment-resistant auditory verbal hallucinationsAVH patientsTreatment of auditory verbal hallucinationsImpact of repetitive transcranial magnetic stimulationEmotion regulation regionsLanguage processing regionsAberrant neural activityHigh-frequency repetitive transcranial magnetic stimulationMagnetic stimulationRTMS interventionNeural substratesNeural effectsNeural mechanismsSham-controlled studySchizophreniaBrain activityNeuroimaging dataProcessing regionsNeuroimaging analysisNeuroimaging outcomesBrain abnormalities
2023
Altered Resting-State Activity and Connectivity in Late-Life Depression with Suicidal Ideation
Wang L, Manning K, Pearlson G, Steffens D. Altered Resting-State Activity and Connectivity in Late-Life Depression with Suicidal Ideation. American Journal Of Geriatric Psychiatry 2023, 31: e22-e23. DOI: 10.1016/j.jagp.2023.02.031.Peer-Reviewed Original ResearchDefault mode networkVentrolateral prefrontal cortexLate-life depressionFunctional connectivityPrefrontal cortexOlder adultsOlder depressed adultsBrain activityDepressed adultsSuicidal ideationGreater brain activityVisual cortexWeaker functional connectivityStronger functional connectivityResting-state fMRI dataResting-state activitySuicidal behaviorWhole-brain voxelwiseNon-SI groupROI functional connectivityDepression severitySI groupCerebellar cortexCerebellar functional connectivityResting activity
2017
92. Peripheral Oxytocin and Vasopressin Modulates Regional Brain Activity Differently in Men and Women With Schizophrenia
Rubin L, Li S, Yao L, Keedy S, Reilly J, Hill S, Bishop J, Carter S, Pournajafi-Nazarloo H, Drogos L, Gershon E, Pearlson G, Tamminga C, Clementz B, Keshavan M, Lui S, Sweeney J. 92. Peripheral Oxytocin and Vasopressin Modulates Regional Brain Activity Differently in Men and Women With Schizophrenia. Schizophrenia Bulletin 2017, 43: s50-s50. PMCID: PMC5475587, DOI: 10.1093/schbul/sbx021.131.Peer-Reviewed Original ResearchHigher AVP levelsHigher ALFFMale patientsCerebellar cortexFrontal cortexArginine vasopressinHigher OT levelsPosterior cingulateOT levelsFemale patientsLower ALFFAVP levelsPoor verbal fluencyHealthy individualsRegional cerebral functionSpontaneous neuronal activitySex-dependent mannerAVP serum concentrationsBrain activityRegional brain activityVerbal fluencyEmotion processingSuperior temporal gyrusClinical associationsSerum concentrations
1991
Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography
Tune L, Brandt J, Frost J, Harris G, Mayberg H, Steele C, Burns A, Sapp J, Folstein M, Wagner H, Pearlson G. Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography. Acta Psychiatrica Scandinavica. Supplementum 1991, 83: 61-65. PMID: 1897377, DOI: 10.1111/j.1600-0447.1991.tb03111.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmphetaminesBlood GlucoseBrainCerebrovascular CirculationDeoxyglucoseDose-Response Relationship, DrugDrug Administration ScheduleFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeuropsychological TestsPhysostigminePilot ProjectsTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsCerebral glucose metabolismCerebral blood flowSingle photon emission tomographyPhoton emission tomographyPositron emission tomographyBlood flowEmission tomographyGlucose metabolismAlzheimer's diseaseRegional cerebral glucose metabolismSignificant clinical improvementCognitive functioningClinical improvementMost patientsIntravenous administrationPatientsDiseasePhysostigmineTomographyBrain activityPreliminary findingsMetabolismPronounced improvementPathophysiologyIllness