2016
Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue
Lai C, Lee S, Scarr E, Yu Y, Lin Y, Liu C, Hwang T, Hsieh M, Liu C, Chien Y, Udawela M, Gibbons A, Everall I, Hwu H, Dean B, Chen W. Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue. Translational Psychiatry 2016, 6: e717-e717. PMID: 26784971, PMCID: PMC5068884, DOI: 10.1038/tp.2015.213.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedBiomarkersBrainFemaleHumansMaleMicroRNAsMiddle AgedReal-Time Polymerase Chain ReactionRemission InductionSchizophreniaYoung AdultConceptsPeripheral miRNAsState-dependent markersDiagnostic of schizophreniaHsa-miR-34aPostmortem brain tissueAberrant expression of microRNAsCaudate putamenSchizophreniaSubcortical regionsAcute stateExpression of microRNAsSeven-miRNARemission stateBrain samplesAberrant expressionClinically useful biomarkersExpression levelsBrainMonths of hospitalizationPartial remission stateAge-dependent increaseMiRNA dysregulationMiRNAsPartial remissionClinical symptoms
2014
The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma
Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao Y, Foo W, Zuo M, Valasek M, Javle M, Wilkinson M, Lu Y. The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma. Nature Medicine 2014, 20: 596-598. PMID: 24859531, PMCID: PMC4048332, DOI: 10.1038/nm.3548.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingBase SequenceCarcinoma, AdenosquamousGene ComponentsHEK293 CellsHumansImmunohistochemistryIn Situ Nick-End LabelingMolecular Sequence DataMutagenesisMutationNonsense Mediated mRNA DecayPancreatic NeoplasmsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA HelicasesSequence Analysis, DNATrans-Activators
2013
MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3.
Liu C, Cheng H, Shi S, Cui X, Yang J, Chen L, Cen P, Cai X, Lu Y, Wu C, Yao W, Qin Y, Liu L, Long J, Xu J, Li M, Yu X. MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3. 2013, 13: 467-78. PMID: 23305226, DOI: 10.2174/1566524011313040001.Peer-Reviewed Original ResearchConceptsMiR-34bTarget of miR-34bMicroRNA-34bTumor-suppressive microRNAMiR-34b expressionPancreatic cancer tissuesLuciferase assayProgression in vitroMicroRNAsCancer tissuesTumor-node-metastasisPancreatic cancerTumor metastasis suppressorTumor-node-metastasis (TNM) stageCancer progression in vitroMiRsLymph-node metastasisPancreatic cancer cellsPancreatic cancer metastasisER stress inducer thapsigargin
2011
Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-deficient Huh 7.5 cells
Yao L, Yan X, Dong H, Nelson D, Liu C, Li X. Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-deficient Huh 7.5 cells. Virology Journal 2011, 8: 445. PMID: 21936899, PMCID: PMC3213043, DOI: 10.1186/1743-422x-8-445.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDEAD Box Protein 58DEAD-box RNA HelicasesGene ExpressionHepacivirusHepatocytesHumansInterferon Regulatory Factor-3Interferon-alphaInterferon-betaMiceProtein BiosynthesisProtein MultimerizationReal-Time Polymerase Chain ReactionReceptors, EstrogenReceptors, ImmunologicRecombinant Fusion ProteinsTranscription, GeneticVirus ReplicationConceptsAnti-HCV effectInterferon regulatory factor 3Huh-7.5 cellsEstrogen receptorPolymerase chain reactionHepatitis C virus infectionViral replicationC virus infectionMouse estrogen receptorHepatitis C viral replicationInterferon-stimulated gene expressionExpression of IFNHCV viral replicationHCV RNA replicationReal-time polymerase chain reactionEstrogen receptor agonistsExpression of ISGsRegulatory factor 3HCV IRES-dependent translationIdentification of the IFITM3 gene as an inhibitor of hepatitis C viral translation in a stable STAT1 cell line
Yao L, Dong H, Zhu H, Nelson D, Liu C, Lambiase L, Li X. Identification of the IFITM3 gene as an inhibitor of hepatitis C viral translation in a stable STAT1 cell line. Journal Of Viral Hepatitis 2011, 18: e523-e529. PMID: 21914072, PMCID: PMC3736357, DOI: 10.1111/j.1365-2893.2011.01452.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell LineGene ExpressionHepacivirusHumansMembrane ProteinsMiceProtein BiosynthesisProtein MultimerizationReal-Time Polymerase Chain ReactionReceptors, EstrogenRecombinant Fusion ProteinsRNA, ViralRNA-Binding ProteinsSTAT1 Transcription FactorTamoxifenTranscriptional ActivationViral ProteinsConceptsFusion proteinCell linesRNA replicationInterferon-induced transmembrane protein 3Internal ribosomal entry siteHCV IRESHCV internal ribosomal entry siteTransmembrane protein 3HCV RNA replicationMouse estrogen receptorSignal transducerTranscription 1Gene expressionViral translationIFITM3 geneHuh7.5 cell lineReal-time PCRAnti-HCV effectGenesEntry siteElevated expressionProtein 3Western blottingIRESProtein