2023
Do Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review.
Wang L, Grimshaw A, Mezzacappa C, Rahimi Larki N, Yang Y, Justice A. Do Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1490-1497. PMID: 37610426, PMCID: PMC10873036, DOI: 10.1158/1055-9965.epi-23-0468.Peer-Reviewed Original ResearchConceptsRoutine risk factorsPancreatic cancerRisk factorsPolygenic risk scoresClinical dataRisk scoreAddition of PRSClinical risk factorsRoutine clinical dataCancer risk predictionDatabase inceptionCancerClinical applicabilityRelevant exposuresGenetic riskRisk predictionCancer-specific polygenic risk scoresScoping ReviewRiskEuropean ancestryPopulation representativeScoresMost studiesAppropriate controlsFactors
2022
The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis
Scierka LE, Mena-Hurtado C, Ahmed ZV, Yousef S, Arham A, Grimshaw AA, Harris KM, Burg M, Vriens PW, Heyligers J, Lee M, Yazgan I, Smolderen KG. The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis. Journal Of Affective Disorders 2022, 320: 169-177. PMID: 36179780, DOI: 10.1016/j.jad.2022.09.098.Peer-Reviewed Original ResearchMeSH KeywordsComorbidityCoronary Artery DiseaseDepressionHumansMalePeripheral Arterial DiseaseRisk FactorsConceptsMajor adverse limb eventsPeripheral artery diseaseAssociation of depressionCause mortalityArtery diseaseDepressive symptomsSystematic reviewAdverse limb eventsAdverse prognostic outcomeCoronary artery diseaseRisk of biasImportant comorbidityPoor outcomeAdverse outcomesPrognostic outcomesPooled resultsRisk factorsObservational studyTreatment statusLimb eventsDepression severityPatientsLarger sample sizeMortalityRisk estimatesClinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S. Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review. Transplantation And Cellular Therapy 2022, 28: 294-302. PMID: 35288347, PMCID: PMC9197870, DOI: 10.1016/j.jtct.2022.03.006.Peer-Reviewed Original ResearchConceptsImmune effector cell-associated neurotoxicity syndromeCAR T-cell therapyT-cell therapyLong-term outcomesHematologic malignanciesCell therapyClinical presentationLymphocytic leukemiaCAR-T cell therapy recipientsChimeric antigen receptor T-cell therapyJoanna Briggs Institute critical appraisal toolsDiffuse large B-cell lymphomaCAR T-cell productsLarge B-cell lymphomaCytokine release syndromeRefractory hematologic malignanciesLong-term sequelaeSubset of patientsC-reactive proteinCommon hematologic malignancyLife-threatening conditionNon-Hodgkin lymphomaCross-trial comparisonsAcute lymphocytic leukemiaChronic lymphocytic leukemia
2021
Late-Stage Pancreatic Cancer Detected During High-Risk Individual Surveillance: A Systematic Review and Meta-Analysis
Chhoda A, Vodusek Z, Wattamwar K, Mukherjee E, Gunderson C, Grimshaw A, Sharma A, Ahuja N, Kastrinos F, Farrell JJ. Late-Stage Pancreatic Cancer Detected During High-Risk Individual Surveillance: A Systematic Review and Meta-Analysis. Gastroenterology 2021, 162: 786-798. PMID: 34813861, DOI: 10.1053/j.gastro.2021.11.021.Peer-Reviewed Original ResearchConceptsLate-stage PDACPancreatic ductal adenocarcinomaHigh-risk individualsHigh-grade precursorsCumulative incidenceAdvanced neoplasiaLate-stage pancreatic cancerTiming of presentationRandom-effects modelWeb of ScienceClinicoradiologic factorsClinicoradiologic featuresSurveillance imagingCochrane LibraryPancreatic cancerDuctal adenocarcinomaPancreatic morphologySurveillance studyFunnel plotLesion sitePDAC stagesSurveillance adherenceSystematic reviewMeta-AnalysisSignificant associationEffect of institutional transcatheter aortic valve replacement volume on mortality: A systematic review and meta‐analysis
Kir D, Shapero K, Chatterjee S, Grimshaw A, Oddleifson A, Spatz ES, Goldsweig AM, Desai NR. Effect of institutional transcatheter aortic valve replacement volume on mortality: A systematic review and meta‐analysis. Catheterization And Cardiovascular Interventions 2021, 98: e453-e461. PMID: 33565695, DOI: 10.1002/ccd.29502.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisHumansRisk FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsLow-volume centersVolume centersTitles/abstractsPatient outcomesTAVR centersTAVR volumeCause mortalitySystematic reviewHigh-volume centersIntermediate-volume centersReplacement volumeFull-text studiesCause mortality dataStrong referral networkFree-text termsSystematic literature searchPre-specified criteriaEligible studiesProcedural volumeExclusion criteriaMortality rateTAVRLiterature searchMortality dataRelevant articles