Yale Medicine Surgeons Use 3D Printing to Benefit Patients
Some Yale Medicine surgeons now routinely use 3D printing (essentially producing a solid, three-dimensional object from a virtual digital model) to plan surgeries, design tools specific to an upcoming surgery and that particular patient’s anatomy, and even to print some of the parts used to replace defective ones in the body.Source: Yale Medicine
Lower synaptic density is associated with depression severity and network alterations
Sophie Holmes, PhD, Associate Research Scientist, and Irina Esterlis, PhD, Associate Professor of Psychiatry, are the first and senior authors, respectively, of a study published in Nature Communications that examined synaptic density in 26 patients with major depressive disorder and post-traumatic stress disorder. The research revealed evidence linking lower synaptic density to network alterations and symptoms of depression.Source: Nature Communications
Connectome-based prediction of cocaine abstinence
Sarah Yip, PhD, MSc, Assistant Professor of Psychiatry, is the first author of a paper published in The American Journal of Psychiatry that tracks the results of a study that used connectome-based predictive modeling to identify neural networks predictive of future abstinence from cocaine.Source: The American Journal of Psychiatry
Mapping metabolism with a Yale-developed imaging technique
Yale researchers have developed a new imaging technique that captures detailed information about metabolism, which plays a role in many diseases. The novel yet simple technique, which harnesses existing technology, could potentially be used to evaluate the effectiveness of drug therapies for cancer and other conditions, the researchers said.
Cerebellar and prefrontal cortical alterations in PTSD: Structural and functional evidence
A Yale Department of Psychiatry and Yale School of Medicine paper published in Chronic Stress shows converging structural and functional evidence for cerebellum abnormalities in posttraumatic stress disorder. Sophie Holmes, PhD, Associate Research Scientist, is the first author.Source: Chronic Stress
Lower brain glucose levels found in people with obesity, type 2 diabetes
Glucose levels are reduced in the brains of individuals with obesity and type 2 diabetes compared to lean individuals, according to a new Yale study. The finding might explain disordered eating behavior — and even a higher risk of Alzheimer’s disease — among obese and diabetic individuals, the researchers said.
Yale launches five-year study of origins of autism
Yale researchers will study the development of functional brain connectivity during late pregnancy to early adolescence thanks to a five-year, $12.4 million grant from Autism Centers of Excellence Program, part of efforts by the National Institutes of Health to understand the origins of autism spectrum disorders (ASD).
How neurofeedback helps patients tamp down their fears
Tiny parts of the brain, School of Medicine researchers are discovering, can have a huge impact on our lives. Michelle Hampson, Ph.D., and Judson A. Brewer, M.D., Ph.D., are leading teams that use real-time fMRI and what’s known as neurofeedback to try to teach people how to control brain activity and combat such problems as anxiety, addiction, Tourette syndrome, and post-traumatic stress disorder (PTSD), as well as more mundane self-imposed roadblocks to success.
Levels of key brain chemicals predict children’s reading ability
Reading-impaired young children have higher levels of the metabolites glutamate and choline in their brains, and these higher levels continue to be indicative of difficulties in developing typical reading and language skills, a Yale study has found. The study appears in the Journal of Neuroscience.
Addicts’ cravings have different roots in men and women
A new brain imaging study by Yale School of Medicine researchers suggests stress robustly activates areas of the brain associated with craving in cocaine-dependent women, while drug cues activate similar brain regions in cocaine-dependent men. The study, expected to be published online Jan. 31 in the American Journal of Psychiatry, suggests men and women with cocaine dependence might benefit more from different treatment options.
Bold Receives Grant to Study Impact of Menthol Flavor Ban in Cigarettes and E-cigarettes
Krysten Bold, PhD, assistant professor of psychiatry, has received an R01 grant from the National Institute on Drug Abuse (NIDA) to study the impact of a menthol flavor ban in cigarettes and e-cigarettes to inform tobacco policy.
Le Zhang, PhD Wins Avenir Award for Research on Substance Use Disorders and HIV/AIDS
Assistant Professor Le Zhang, PhD was recently awarded a DP2 grant from the National Institutes of Health (NIH), entitled “Immune Network Dysregulation of the Central Nervous System with HIV Persistence and Opioid Abuse.” The grant, which amounts to more than $2.5 million, began on May 15, 2022 and lasts for four years.