2010
Common Genes Contribute to Depressive Symptoms and Heart Rate Variability: The Twins Heart Study
Su S, Lampert R, Lee F, Bremner JD, Snieder H, Jones L, Murrah NV, Goldberg J, Vaccarino V. Common Genes Contribute to Depressive Symptoms and Heart Rate Variability: The Twins Heart Study. Twin Research And Human Genetics 2010, 13: 1-9. PMID: 20158303, PMCID: PMC2905576, DOI: 10.1375/twin.13.1.1.Peer-Reviewed Original ResearchConceptsHeart rate variabilityCoronary artery diseaseDepressive symptomsHRV indicesReduced heart rate variabilityRate variabilityElectrocardiographic Holter recordingsMeasurements of HRVBeck Depression Inventory-IICurrent depressive symptomsSignificant inverse correlationVietnam Era Twin RegistryFrequency domain variablesBivariate genetic modelingCommon neurobiological dysfunctionArtery diseaseAutonomic dysregulationHolter recordingsHeart StudyMiddle-aged male twinsHRV frequencySymptomsCommon genetic componentInventory-IIHigh frequency
2009
Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins
Su S, Lampert R, Zhao J, Bremner JD, Miller A, Snieder H, Lee F, Khan D, Goldberg J, Vaccarino V. Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins. The American Journal Of Cardiology 2009, 104: 1748-1754. PMID: 19962488, PMCID: PMC2818743, DOI: 10.1016/j.amjcard.2009.07.063.Peer-Reviewed Original ResearchConceptsC-reactive protein levelsHeart rate variabilityCRP gene polymorphismsCoronary artery diseaseCRP levelsGene polymorphismsArtery diseaseHRV indicesSymptomatic coronary artery diseaseReduced heart rate variabilityRate variabilityLower heart rate variabilityC-Reactive Protein Gene PolymorphismsPlasma CRP levelsCRP plasma levelsCRP single-nucleotide polymorphismsMale twinsProtein levelsSingle nucleotide polymorphismsHealthy male twinsBivariate structural equation modelingHigh-frequency powerCRP geneFrequency domain measuresProtein gene polymorphisms