Gut check: Yale researchers describe role of bacteria in drug response
Yale researchers identified human gut microbes that metabolize over 150 therapeutic drugs, a finding that highlights the role bacteria play in determining how well individuals respond to medications, they report June 3 in the journal Nature.
Microbiome could be culprit when good drugs do harm
People sometimes suffer toxic side effects from drugs that help many others. Yale scientists have identified a surprising explanation — the gut microbiome. The research, published Feb. 8 in the journal Science, describes how bacteria in the gut can transform three drugs into harmful compounds. “If we can understand the microbiome’s contributions to drug metabolism, we can decide which drugs to give to patients or even alter the microbiome so patients have a better response,” said co-lead author Michael Zimmermann, postdoctoral fellow in the lab of senior author Andrew Goodman in the Department of Microbial Pathogenesis and the Microbial Sciences Institute.
Innovative way to block HIV runs into a roadblock
A Yale team led by Pradeep Uchil and Walther Mothes found that taking aim at a promising molecular target can combat the spread of retroviruses that can cause blood cancer and AIDS — but at the risk of leaving the host vulnerable to infections by other viral pathogens.
New imaging facility is a "revolution"
Microscopy at Yale has just received a major upgrade. Structural biologists at the School of Medicine and scientists from across the university have begun obtaining three-dimensional images at near-atomic resolutions from what Jorge E. Galán, Ph.D., D.V.M., chair and Lucille P. Markey Professor of Microbial Pathogenesis and professor of cell biology, calls “the mother of all microscopes.” The Titan Krios cryoelectron microscope arrived at West Campus in January and was dedicated in June.
Unpredictability the key to “rewiring” our fight against infection: In conversation with Professor John MacMicking
John MacMicking of the Systems Biology Institute talks about his work to integrate abstract and experimental science in an effort to “rewire” the host immune response to infection. Dr. MacMicking is an Investigator of the Howard Hughes Medical Institute (HHMI) and tenured Associate Professor of Microbial Pathogenesis and of Immunobiology at the School of Medicine.
Celebrating 18 Years of Microbial Pathogenesis at Yale on the Occasion of Jorge Galán’s 60th Birthday
The Department of Microbial Pathogenesis is pleased to invite our colleagues and friends to attend a symposium on Oct. 14 commemorating 18 years of Microbial Pathogenesis at Yale University, being held on the occasion of Dr. Jorge Galán’s 60th birthday. Following the symposium there will be a reception open to all participants at the Peabody Museum.
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
Bacterial brawls mark life in the gut’s microbiome
Bacterially speaking, it gets very crowded in the human gut, with trillions of cells jostling for a position to carry out a host of specialized and often crucial tasks. A new Yale study, published the week of March 7 in the journal of the Proceedings of the National Academy of Sciences suggests these “friendly” bacteria aggressively stake out their territory, injecting lethal toxins into any other cells that dare bump into them.