Researchers develop a novel RNA-based therapy to target West Nile Virus
A Yale-led research team developed a new RNA therapy, delivered through the nose, to treat mice infected with West Nile Virus. The innovative approach reduced the virus in the brain, allowing the immune system to destroy the virus and develop long-term protection against West Nile Virus disease, the researchers said.
Unpredictability the key to “rewiring” our fight against infection: In conversation with Professor John MacMicking
John MacMicking of the Systems Biology Institute talks about his work to integrate abstract and experimental science in an effort to “rewire” the host immune response to infection. Dr. MacMicking is an Investigator of the Howard Hughes Medical Institute (HHMI) and tenured Associate Professor of Microbial Pathogenesis and of Immunobiology at the School of Medicine.
Celebrating 18 Years of Microbial Pathogenesis at Yale on the Occasion of Jorge Galán’s 60th Birthday
The Department of Microbial Pathogenesis is pleased to invite our colleagues and friends to attend a symposium on Oct. 14 commemorating 18 years of Microbial Pathogenesis at Yale University, being held on the occasion of Dr. Jorge Galán’s 60th birthday. Following the symposium there will be a reception open to all participants at the Peabody Museum.
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
Why Is COVID-19 Striking Men Harder Than Women?
Women's Health Research at Yale Director Carolyn M. Mazure and Immunobiology Professor Akiko Iwasaki, discuss how understanding why men suffer more severe cases of COVID-19 and are more likely to die is vital for developing effective strategies that can produce better outcomes for everyone.
How T Cells Make Sure They Have Quiet Time
All cells, like all people, need “quiet” time to function properly, and this is particularly true of T cells, one of the immune system’s main weapons. They must be ready for activation at all times, and primed to divide more rapidly than almost any cell in the body.
The harmful effects of stress during pregnancy can last a lifetime
Mice exposed to stress in the womb and soon after birth can expect a lifetime of immune system deficiencies that hinder the ability to ward off infections and cancer, Yale University researchers report March 5 in the journal Cell.
From Paradox to Breakthrough
Aaron Ring, MD, PhD, was hooked by a paradox. He had been studying cytokines to understand their potential to stimulate anti-tumor immunity. Though cytokines, such as interleukin-2, have been in clinical use for decades, they have historically shown only limited effectiveness. Dr. Ring was hunting for interleukins that could deliver a specific signal to activate TILs.
Richard Flavell Is Named a Distinguished Fellow by the American Association of Immunologists
Richard A. Flavell, PhD, is one of 20 scientists who have been named Distinguished Fellows by the American Association of Immunologists, which recognizes members for distinguished careers and outstanding scientific contributions, as well as their service to AAI and the immunology community. It is one of the highest honors that AAI bestows.
Yale Scientists Breach Brain Barriers to Attack Tumors
The brain is a sort of fortress, equipped with barriers designed to keep out dangerous pathogens. But protection comes at a cost: These barriers interfere with the immune system when faced with dire threats such glioblastoma, a deadly brain tumor for which there are few effective treatments.
Yale Receives Funding to Study Myasthenia Gravis
The National Institutes of Health through the Rare Diseases Clinical Research Consortia has awarded a research team from Yale University, George Washington University, and Duke University $7.8 million to establish a rare disease network for myasthenia gravis.