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Bacteria are unicellular, prokaryotic organisms that live all around and within us, usually without incident. However, a number of important bacterial pathogens can cause opportunistic infections that are severe or life threatening. The bacteriologists within the Department have made numerous contributions to our understanding of how bacteria cause disease.


Research interests

Jason Crawford, Ph.D.

Bacteria; Chemistry; Host-Pathogen Interactions. Crawford Lab

Charles Dela Cruz, M.D., Ph.D.

Respiratory Tract Infections; Pulmonary Disease, Chronic Obstructive. Dela Cruz Lab

Erol Fikrig, M.D.

Tick-borne transmission of Borrelia burgdorferi (the causative agent of Lyme disease) and Anaplasma phagocytophilum (which causes human granulocytic anaplasmosis); innate immune responses and vaccine design.

Jorge Galán, D.V.M., Ph.D.

Galán Lab Bacterial type III secretion systems; virulence determinants of food-borne pathogens Salmonellatyphimurium, S. typhi, and Campylobacter jejuni .

Andrew Goodman, Ph.D.

Goodman Lab Microbial communities within the gut; the relationship between microbiota composition and function; functional genome-wide analysis.

Eduardo Groisman, Ph.D.

Groisman Lab Bacterial two-component signal transduction in Salmonella enterica (which causes gastroenteritis and typhoid fever), Yersinia pestis (which causes bubonic plague), and Escherichia coli (which is a commensal bacteria of the gut); genetic networks and differential gene control; riboswitches.

Christine Jacobs-Wagner, Ph.D.

Bacterial cell biology, morphology, and cell division of Caulobacter crescentus. Jacobs-Wagner Lab

Raymond Johnson, M.D., Ph.D.

Chlamydia trachomatis; Trachoma; Infectious Disease Medicine.

Barbara Kazmierczak, M.D., Ph.D.

Virulence factors of Pseudomonas aeruginosa; bacterial biofilm formation.

John MacMicking, Ph.D.

Innate immunity to Mycobacterium tuberculosis, the causative agent of tuberculosis; interferon-induced GTPases.

Hesper Rego, Ph.D.

Rego Lab Bacteria; Cell Biology; Imaging, Three-Dimensional; Single-Cell Analysis.

Craig Roy, Ph.D.

Remodeling of the host cellular secretory pathway by Legionella pneumophila (Legionnaire’s disease) and Coxiella burnetii (Q fever) effector proteins; bacterial evasion of innate immune responses.