2024
Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma
Chen Y, Zhang Z, Pan F, Li P, Yao W, Chen Y, Xiong L, Wang T, Li Y, Huang G. Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma. Journal Of Experimental & Clinical Cancer Research 2024, 43: 210. PMID: 39075504, PMCID: PMC11285179, DOI: 10.1186/s13046-024-03135-3.Peer-Reviewed Original ResearchConceptsAnti-angiogenesis therapyAnti-angiogenesis treatmentVascular normalizationTumor microenvironmentMagnetic-activated cell sortingAnti-angiogenesisTumor tissuesTumor vascular normalizationEfficacy of chemotherapyHuman lung adenocarcinoma cell line A549Expression of CCL28Lung adenocarcinoma cell line A549Adenocarcinoma cell line A549Adenocarcinoma tumor tissuesStabilization of endothelial cellsClinical biopsy samplesRetinoic acidLung adenocarcinoma tumor tissuesCCL28 proteinMurine tumor tissuesCombination therapyTargeted therapyMultiplex immunohistochemistryState of ischemiaPericyte coverageCommensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor
Tian K, Jing D, Lan J, Lv M, Wang T. Commensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor. Immunity Inflammation And Disease 2024, 12: e1316. PMID: 39023417, PMCID: PMC11256888, DOI: 10.1002/iid3.1316.Peer-Reviewed Original ResearchConceptsMucosal immune networkMucosal immune systemImmune systemMaintenance of intestinal healthSite of pathogen invasionPresence of commensal microbiotaImmune responsePattern recognition receptorsGut mucosal immune systemAntigen-presenting cellsMucosal immune cellsGastrointestinal mucosal immunityGut-associated lymphoid tissuePathogen invasionCommensal microbiotaGut homeostasisMicrobial communitiesProtective immune responsesAdaptive immune responsesNon-self antigensCommensal bacteriaCommensal microbiomeIntestinal healthInflammatory bowel diseaseRecognition receptorsFrom metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review)
Li T, Feng W, Yan W, Wang T. From metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review). Molecular Medicine Reports 2024, 30: 145. PMID: 38904193, DOI: 10.3892/mmr.2024.13269.Peer-Reviewed Original ResearchConceptsTrained immunityTrained macrophagesAbundant immune cellsCharacteristics of innate immunityChronic inflammatory diseaseAtherosclerotic plaquesProgression of ASImmune cellsInflammatory diseasesImmune responseTherapeutic approachesClinical strategiesEpigenetic reprogrammingDeposition of lipoproteinsCardiovascular diseaseInnate immunityMacrophagesAtherosclerosisImmunityDiseasePlaqueCellsComplex mechanismsMitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity
Zhang Z, Li P, Chen Y, Chen Y, Wang X, Shen S, Zhao Y, Zhu Y, Wang T. Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity. Cell Communication And Signaling 2024, 22: 210. PMID: 38566195, PMCID: PMC10986078, DOI: 10.1186/s12964-024-01581-2.Peer-Reviewed Original ResearchConceptsMitochondrial oxidative phosphorylationDisseminated candidiasisC. tropicalisMyeloid-derived suppressor cellsAntifungal immunityOxidative phosphorylationAcute kidney injuryMolecular mechanismsExpression of solute carrier family 7 memberExpression of mitochondrial proteinsInhibition of mitochondrial oxidative phosphorylationKidney injurySolute carrier family 7 memberSusceptible to ferroptosisRNA sequencing analysisCandida tropicalisQuantitative real-time PCRHost antifungal immunityMitochondrial proteinsC-type lectin receptorsIncreased susceptibility to acute kidney injuryProportion of myeloid-derived suppressor cellsCARD9Susceptibility to acute kidney injuryReal-time PCRAcatulides A-G, neuroprotective macrolides from Acaulium album H-JQSF
Tong Z, Wang T, Yang P, Sun J, Zhang C, Khan S, Wang X, Jiao R, Ge H, Zhuang W, Hu G, Tan R. Acatulides A-G, neuroprotective macrolides from Acaulium album H-JQSF. Chinese Chemical Letters 2024, 35: 108488. DOI: 10.1016/j.cclet.2023.108488.Peer-Reviewed Original ResearchIrpetones A and B, Anti-Osteoclastic Heptaketides from a Marine Mesophotic Zone Ircinia Sponge-Associated Fungus Irpex sp. NBUF088
Wang T, Tian J, Huang J, Yuan Y, Naman C, Wu S, Wang H, Lin W, Tong Z, Ding L, Wang W, He S. Irpetones A and B, Anti-Osteoclastic Heptaketides from a Marine Mesophotic Zone Ircinia Sponge-Associated Fungus Irpex sp. NBUF088. Journal Of Natural Products 2024, 87: 1203-1208. PMID: 38359398, DOI: 10.1021/acs.jnatprod.3c01078.Peer-Reviewed Original ResearchPestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145
Wang T, Feng Y, Huang J, Wu S, Hu K, Wu J, Naman C, Wang H, Lin W, He S. Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145. Journal Of Natural Products 2024, 87: 160-165. PMID: 38194474, DOI: 10.1021/acs.jnatprod.3c00892.Peer-Reviewed Original Research
2023
PANoptosis in cancer, the triangle of cell death
Cai H, Lv M, Wang T. PANoptosis in cancer, the triangle of cell death. Cancer Medicine 2023, 12: 22206-22223. PMID: 38069556, PMCID: PMC10757109, DOI: 10.1002/cam4.6803.Peer-Reviewed Original ResearchA novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases
Al-Thani M, Goodwin-Trotman M, Bell S, Patel K, Fleming L, Vilain C, Abramowicz M, Allan S, Wang T, Cader M, Horsburgh K, Van Agtmael T, Sinha S, Markus H, Granata A. A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases. Stem Cell Reports 2023, 18: 2386-2399. PMID: 37977146, PMCID: PMC10724071, DOI: 10.1016/j.stemcr.2023.10.014.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseMatrix metalloproteinasesVessel diseaseCerebral small vessel diseaseKey pathogenic roleEndothelial cell tight junctionsHuman iPSC modelSVD pathologyCo-culture modelLeading causePathogenic roleCell phenotypic changesExtracellular matrixParacrine actionCell tight junctionsMMP activityTherapeutic opportunitiesECM abnormalitiesCell defectsEndothelial cellsMural cellsSmall vesselsTight junctionsIPSC modelsDiseaseA multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia
Sri S, Greenstein A, Granata A, Collcutt A, Jochems A, McColl B, Castro B, Webber C, Reyes C, Hall C, Lawrence C, Hawkes C, Pegasiou-Davies C, Gibson C, Crawford C, Smith C, Vivien D, McLean F, Wiseman F, Brezzo G, Lalli G, Pritchard H, Markus H, Bravo-Ferrer I, Taylor J, Leiper J, Berwick J, Gan J, Gallacher J, Moss J, Goense J, McMullan L, Work L, Evans L, Stringer M, Ashford M, Abulfadl M, Conlon N, Malhotra P, Bath P, Canter R, Brown R, Ince S, Anderle S, Young S, Quick S, Szymkowiak S, Hill S, Allan S, Wang T, Quinn T, Procter T, Farr T, Zhao X, Yang Z, Hainsworth A, Wardlaw J. A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia. Cerebral Circulation - Cognition And Behavior 2023, 5: 100189. PMID: 37941765, PMCID: PMC10628644, DOI: 10.1016/j.cccb.2023.100189.Peer-Reviewed Original ResearchVascular cognitive impairmentAlzheimer's diseaseAD brain pathologySmall vessel diseaseClinical featuresMixed pathologyMost dementiasVascular dementiaVessel diseaseVascular contributionsBrain pathologyCognitive impairmentDementiaPreclinical researchOlder peopleDiseasePathologyCommon typeDementia researchHuman pathologiesVCI modelPathogenesisEtiologyImpairmentLow expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis
Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y, Zhao S, Wang T. Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis. International Journal Of Biological Sciences 2023, 19: 4672-4688. PMID: 37781028, PMCID: PMC10535707, DOI: 10.7150/ijbs.81595.Peer-Reviewed Original ResearchConceptsReversible epigenetic modificationAbundant internal modificationPhosphoinositide-3-kinase regulatory subunit 1Glucosidase II alpha subunitRNA immunoprecipitation sequencingM6A reader proteinM6A-dependent mannerRegulatory subunit 1Reader proteinsYTH domainOvarian cancer progressionReader YTHDC1Chromatin immunoprecipitationImmunoprecipitation sequencingWestern blotEpigenetic modificationsGlycan biosynthesisBioinformatics analysisRNA sequencingRNA immunoprecipitationSignal transducerBiological roleGene expressionRegulatory mechanismsTranscription 3Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Zhang W, Zhao X, Qi X, Kimber S, Hooper N, Wang T. Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. Frontiers In Cellular Neuroscience 2023, 17: 1195470. PMID: 37361999, PMCID: PMC10285224, DOI: 10.3389/fncel.2023.1195470.Peer-Reviewed Original ResearchBrain microvascular endothelial-like cellsTransendothelial electrical resistanceCerebral autosomal dominant arteriopathyAutosomal dominant arteriopathyCADASIL patientsNeurovascular interactionsMural cellsNeurovascular unitSubcortical infarctsBlood-brain barrier functionPluripotent stem cell modelsBarrier functionBrain MRI lesionsSmall vessel diseaseBrain barrier functionCortical projection neuronsStem cell modelWild-type astrocytesFuture therapeutic developmentNVU cell typesVascular mural cellsEarly disease pathologyInduced Pluripotent Stem Cell ModelRecurrent strokeCell typesEditorial: Fungal secondary metabolites as valuable chemical entities for medicines and agrochemicals
Wang W, Wang T. Editorial: Fungal secondary metabolites as valuable chemical entities for medicines and agrochemicals. Frontiers In Microbiology 2023, 14: 1150023. PMID: 36814564, PMCID: PMC9939815, DOI: 10.3389/fmicb.2023.1150023.Peer-Reviewed Original Research
2022
Front Cover: Guignardones Y–Z, Antiviral Meroterpenes from Penicillium sp. NBUF154 Associated with a Crella Sponge from the Marine Mesophotic Zone (Chem. Biodiversity 8/2022)
Zou J, Wu J, Ding L, Wang W, Liu Y, Feng Y, Lai Q, Lin W, Wang T, He S. Front Cover: Guignardones Y–Z, Antiviral Meroterpenes from Penicillium sp. NBUF154 Associated with a Crella Sponge from the Marine Mesophotic Zone (Chem. Biodiversity 8/2022). Chemistry & Biodiversity 2022, 19 DOI: 10.1002/cbdv.202200724.Peer-Reviewed Original ResearchCoral reef habitatsMesophotic coral ecosystemsCoral ecosystemsReef habitatsMesophotic zoneSponge-associated fungiActive secondary metabolitesShallow counterpartsPenicillium spFungus Penicillium spSecondary metabolitesSpGuignardone AFermentation brothEcosystemsHabitatsEC50 valuesMCESpongesBroad spectrumMeroterpenesBlumenol AFungiNew meroterpenesLast decadeGuignardones Y–Z, Antiviral Meroterpenes from Penicillium sp. NBUF154 Associated with a Crella Sponge from the Marine Mesophotic Zone
Zou J, Wu J, Ding L, Wang W, Liu Y, Feng Y, Lai Q, Lin W, Wang T, He S. Guignardones Y–Z, Antiviral Meroterpenes from Penicillium sp. NBUF154 Associated with a Crella Sponge from the Marine Mesophotic Zone. Chemistry & Biodiversity 2022, 19: e202200475. PMID: 35766362, DOI: 10.1002/cbdv.202200475.Peer-Reviewed Original ResearchTargeted Isolation of Two New Anti-inflammatory and UV-A Protective Dipyrroloquinones from the Sponge-associated Fungus Aspergillus tamarii MCCF102 #
Niveditha L, Fu P, Leao T, Li T, Wang T, Poulin R, Gaspar L, Naman C, Puthiyedathu S. Targeted Isolation of Two New Anti-inflammatory and UV-A Protective Dipyrroloquinones from the Sponge-associated Fungus Aspergillus tamarii MCCF102 #. Planta Medica 2022, 88: 774-782. PMID: 35148546, DOI: 10.1055/a-1769-8480.Peer-Reviewed Original ResearchAcremocholone, an Anti‐Vibrio Steroid from the Marine Mesophotic Zone Ciocalypta Sponge‐Associated Fungus Acremonium sp. NBUF150
Feng Y, Wang H, Wu J, Shao P, Zhou W, Lai Q, Lin H, Naman C, Wang T, He S. Acremocholone, an Anti‐Vibrio Steroid from the Marine Mesophotic Zone Ciocalypta Sponge‐Associated Fungus Acremonium sp. NBUF150. Chemistry & Biodiversity 2022, 19: e202200028. PMID: 35194947, DOI: 10.1002/cbdv.202200028.Peer-Reviewed Original ResearchConceptsMesophotic coral ecosystemsV. shiloniiV. brasiliensisAcremonium sp.Sponge-associated fungiFungus Acremonium sp.Vibrio scophthalmiCoral ecosystemsBioactive metabolitesInhibitory concentrationAntimicrobial inhibitionBrasiliensisFungiAquaculture useX-ray crystallographyNatural productsHR-ESI-MSSpongeSouth China SeaSp.AcremoniumAbsolute configurationChina SeaCompounds 1Spectroscopic dataDendronecholones A-D, new anti-Vibrio steroids isolated from East China Sea Dendronephthya soft coral
Wang T, Zou J, Li T, Shao P, Zhou W, Lai Q, Feng Y, Naman C, Yan X, He S. Dendronecholones A-D, new anti-Vibrio steroids isolated from East China Sea Dendronephthya soft coral. Aquaculture 2022, 549: 737727. DOI: 10.1016/j.aquaculture.2021.737727.Peer-Reviewed Original ResearchCurrent Progress in Vascular Engineering and Its Clinical Applications
Jouda H, Murillo L, Wang T. Current Progress in Vascular Engineering and Its Clinical Applications. Cells 2022, 11: 493. PMID: 35159302, PMCID: PMC8834640, DOI: 10.3390/cells11030493.Peer-Reviewed Original ResearchConceptsSmall diameter vascular conduitsAutologous vesselsVascular tissue engineeringHealthy autologous vesselsTensile strengthBiodegradable synthetic materialsTissue engineeringVascular engineeringTEVGsLarge-scale productionSynthetic materialsPromising solutionAdvanced technologiesVascular graftsEngineeringVascular scaffoldsGreat challengeVascular conduitsScaffoldsApplicationsMesenchyme stem cellsBiocompatibilityAdditional difficultiesKey factorsStrengthTargeted Discovery of Amantamide B, an Ion Channel Modulating Nonapeptide from a South China Sea Oscillatoria Cyanobacterium
Li T, Xi C, Yu Y, Wang N, Wang X, Iwasaki A, Fang F, Ding L, Li S, Zhang W, Yuan Y, Wang T, Yan X, He S, Cao Z, Naman C. Targeted Discovery of Amantamide B, an Ion Channel Modulating Nonapeptide from a South China Sea Oscillatoria Cyanobacterium. Journal Of Natural Products 2022, 85: 493-500. PMID: 34986303, DOI: 10.1021/acs.jnatprod.1c00983.Peer-Reviewed Original ResearchConceptsChiral-phase HPLC analysisChemical degradationConfigurational assignmentDereplication toolLC-MS/MSTargeted isolationU937 human histiocytic lymphoma cellsTargeted discoveryGPCR targetsFilamentous cyanobacteriumNotable cytotoxicityOrganic extractsHuman histiocytic lymphoma cellsHistiocytic lymphoma cellsCompoundsHuman T lymphoblastoid cellsCXCR7 agonistPrimary cultured neocortical neuronsMethyl esterLymphoblastoid cellsMoleculesT-lymphoblastoid cellsCyanobacteriumNonapeptide analoguesΜM