2024
Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma
Chen Y, Zhang Z, Pan F, Li P, Yao W, Chen Y, Xiong L, Wang T, Li Y, Huang G. Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma. Journal Of Experimental & Clinical Cancer Research 2024, 43: 210. PMID: 39075504, PMCID: PMC11285179, DOI: 10.1186/s13046-024-03135-3.Peer-Reviewed Original ResearchConceptsAnti-angiogenesis therapyAnti-angiogenesis treatmentVascular normalizationTumor microenvironmentMagnetic-activated cell sortingAnti-angiogenesisTumor tissuesTumor vascular normalizationEfficacy of chemotherapyHuman lung adenocarcinoma cell line A549Expression of CCL28Lung adenocarcinoma cell line A549Adenocarcinoma cell line A549Adenocarcinoma tumor tissuesStabilization of endothelial cellsClinical biopsy samplesRetinoic acidLung adenocarcinoma tumor tissuesCCL28 proteinMurine tumor tissuesCombination therapyTargeted therapyMultiplex immunohistochemistryState of ischemiaPericyte coverageCommensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor
Tian K, Jing D, Lan J, Lv M, Wang T. Commensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor. Immunity Inflammation And Disease 2024, 12: e1316. PMID: 39023417, PMCID: PMC11256888, DOI: 10.1002/iid3.1316.Peer-Reviewed Original ResearchConceptsMucosal immune networkMucosal immune systemImmune systemMaintenance of intestinal healthSite of pathogen invasionPresence of commensal microbiotaImmune responsePattern recognition receptorsGut mucosal immune systemAntigen-presenting cellsMucosal immune cellsGastrointestinal mucosal immunityGut-associated lymphoid tissuePathogen invasionCommensal microbiotaGut homeostasisMicrobial communitiesProtective immune responsesAdaptive immune responsesNon-self antigensCommensal bacteriaCommensal microbiomeIntestinal healthInflammatory bowel diseaseRecognition receptorsFrom metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review)
Li T, Feng W, Yan W, Wang T. From metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review). Molecular Medicine Reports 2024, 30: 145. PMID: 38904193, DOI: 10.3892/mmr.2024.13269.Peer-Reviewed Original ResearchConceptsTrained immunityTrained macrophagesAbundant immune cellsCharacteristics of innate immunityChronic inflammatory diseaseAtherosclerotic plaquesProgression of ASImmune cellsInflammatory diseasesImmune responseTherapeutic approachesClinical strategiesEpigenetic reprogrammingDeposition of lipoproteinsCardiovascular diseaseInnate immunityMacrophagesAtherosclerosisImmunityDiseasePlaqueCellsComplex mechanisms
2023
PANoptosis in cancer, the triangle of cell death
Cai H, Lv M, Wang T. PANoptosis in cancer, the triangle of cell death. Cancer Medicine 2023, 12: 22206-22223. PMID: 38069556, PMCID: PMC10757109, DOI: 10.1002/cam4.6803.Peer-Reviewed Original ResearchA novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases
Al-Thani M, Goodwin-Trotman M, Bell S, Patel K, Fleming L, Vilain C, Abramowicz M, Allan S, Wang T, Cader M, Horsburgh K, Van Agtmael T, Sinha S, Markus H, Granata A. A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases. Stem Cell Reports 2023, 18: 2386-2399. PMID: 37977146, PMCID: PMC10724071, DOI: 10.1016/j.stemcr.2023.10.014.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseMatrix metalloproteinasesVessel diseaseCerebral small vessel diseaseKey pathogenic roleEndothelial cell tight junctionsHuman iPSC modelSVD pathologyCo-culture modelLeading causePathogenic roleCell phenotypic changesExtracellular matrixParacrine actionCell tight junctionsMMP activityTherapeutic opportunitiesECM abnormalitiesCell defectsEndothelial cellsMural cellsSmall vesselsTight junctionsIPSC modelsDiseaseLow expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis
Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y, Zhao S, Wang T. Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis. International Journal Of Biological Sciences 2023, 19: 4672-4688. PMID: 37781028, PMCID: PMC10535707, DOI: 10.7150/ijbs.81595.Peer-Reviewed Original ResearchConceptsReversible epigenetic modificationAbundant internal modificationPhosphoinositide-3-kinase regulatory subunit 1Glucosidase II alpha subunitRNA immunoprecipitation sequencingM6A reader proteinM6A-dependent mannerRegulatory subunit 1Reader proteinsYTH domainOvarian cancer progressionReader YTHDC1Chromatin immunoprecipitationImmunoprecipitation sequencingWestern blotEpigenetic modificationsGlycan biosynthesisBioinformatics analysisRNA sequencingRNA immunoprecipitationSignal transducerBiological roleGene expressionRegulatory mechanismsTranscription 3
2022
Guignardones Y–Z, Antiviral Meroterpenes from Penicillium sp. NBUF154 Associated with a Crella Sponge from the Marine Mesophotic Zone
Zou J, Wu J, Ding L, Wang W, Liu Y, Feng Y, Lai Q, Lin W, Wang T, He S. Guignardones Y–Z, Antiviral Meroterpenes from Penicillium sp. NBUF154 Associated with a Crella Sponge from the Marine Mesophotic Zone. Chemistry & Biodiversity 2022, 19: e202200475. PMID: 35766362, DOI: 10.1002/cbdv.202200475.Peer-Reviewed Original ResearchTargeted Discovery of Amantamide B, an Ion Channel Modulating Nonapeptide from a South China Sea Oscillatoria Cyanobacterium
Li T, Xi C, Yu Y, Wang N, Wang X, Iwasaki A, Fang F, Ding L, Li S, Zhang W, Yuan Y, Wang T, Yan X, He S, Cao Z, Naman C. Targeted Discovery of Amantamide B, an Ion Channel Modulating Nonapeptide from a South China Sea Oscillatoria Cyanobacterium. Journal Of Natural Products 2022, 85: 493-500. PMID: 34986303, DOI: 10.1021/acs.jnatprod.1c00983.Peer-Reviewed Original ResearchConceptsChiral-phase HPLC analysisChemical degradationConfigurational assignmentDereplication toolLC-MS/MSTargeted isolationU937 human histiocytic lymphoma cellsTargeted discoveryGPCR targetsFilamentous cyanobacteriumNotable cytotoxicityOrganic extractsHuman histiocytic lymphoma cellsHistiocytic lymphoma cellsCompoundsHuman T lymphoblastoid cellsCXCR7 agonistPrimary cultured neocortical neuronsMethyl esterLymphoblastoid cellsMoleculesT-lymphoblastoid cellsCyanobacteriumNonapeptide analoguesΜM
2021
Targeted Isolation of a Cytotoxic Cyclic Hexadepsipeptide from the Mesophotic Zone Sponge-Associated Fungus Cymostachys sp. NBUF082
Yuan Y, Li T, Wang T, Naman C, Ye J, Wu X, Lazaro J, Yan X, He S. Targeted Isolation of a Cytotoxic Cyclic Hexadepsipeptide from the Mesophotic Zone Sponge-Associated Fungus Cymostachys sp. NBUF082. Marine Drugs 2021, 19: 565. PMID: 34677465, PMCID: PMC8540034, DOI: 10.3390/md19100565.Peer-Reviewed Original ResearchCytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144
Zhou J, Zhang H, Ye J, Wu X, Wang W, Lin H, Yan X, Lazaro J, Wang T, Naman C, He S. Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144. Marine Drugs 2021, 19: 186. PMID: 33810590, PMCID: PMC8065988, DOI: 10.3390/md19040186.Peer-Reviewed Original ResearchMarine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity
Zhang H, Zou J, Yan X, Chen J, Cao X, Wu J, Liu Y, Wang T. Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity. Marine Drugs 2021, 19: 180. PMID: 33806230, PMCID: PMC8066444, DOI: 10.3390/md19040180.Peer-Reviewed Original ResearchGlobal proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease
Pokhilko A, Brezzo G, Handunnetthi L, Heilig R, Lennon R, Smith C, Allan S, Granata A, Sinha S, Wang T, Markus H, Naba A, Fischer R, Van Agtmael T, Horsburgh K, Cader M. Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease. Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2423-2438. PMID: 33730931, PMCID: PMC8392779, DOI: 10.1177/0271678x211004307.Peer-Reviewed Original Research
2020
Varying levels of serum estradiol do not alter the timing of the early endometrial secretory transformation
Osman E, Wang T, Zhan Y, Juneau C, Morin S, Seli E, Scott R, Franasiak J. Varying levels of serum estradiol do not alter the timing of the early endometrial secretory transformation. Human Reproduction 2020, 35: 1637-1647. PMID: 32613240, DOI: 10.1093/humrep/deaa135.Peer-Reviewed Original ResearchConceptsEndometrial secretory transformationWindow of implantationSecretory transformationE2 levelsPg/IVF cyclesEndometrial biopsyEndometrial responseStimulation cyclesE2 concentrationsStudy designSTUDY FUNDING/COMPETINGSupraphysiologic E2 levelsSupraphysiologic estradiol levelsClinical pregnancy rateControlled ovarian stimulationEndometrial biopsy specimensFresh embryo transferHistory of infertilityPARTICIPANTS/MATERIALSROLE OF CHANCEEmbryonic competenceE2 riseEndometrial assessmentIntramuscular P4