2024
Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma
Chen Y, Zhang Z, Pan F, Li P, Yao W, Chen Y, Xiong L, Wang T, Li Y, Huang G. Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma. Journal Of Experimental & Clinical Cancer Research 2024, 43: 210. PMID: 39075504, PMCID: PMC11285179, DOI: 10.1186/s13046-024-03135-3.Peer-Reviewed Original ResearchConceptsAnti-angiogenesis therapyAnti-angiogenesis treatmentVascular normalizationTumor microenvironmentMagnetic-activated cell sortingAnti-angiogenesisTumor tissuesTumor vascular normalizationEfficacy of chemotherapyHuman lung adenocarcinoma cell line A549Expression of CCL28Lung adenocarcinoma cell line A549Adenocarcinoma cell line A549Adenocarcinoma tumor tissuesStabilization of endothelial cellsClinical biopsy samplesRetinoic acidLung adenocarcinoma tumor tissuesCCL28 proteinMurine tumor tissuesCombination therapyTargeted therapyMultiplex immunohistochemistryState of ischemiaPericyte coverageMitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity
Zhang Z, Li P, Chen Y, Chen Y, Wang X, Shen S, Zhao Y, Zhu Y, Wang T. Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity. Cell Communication And Signaling 2024, 22: 210. PMID: 38566195, PMCID: PMC10986078, DOI: 10.1186/s12964-024-01581-2.Peer-Reviewed Original ResearchConceptsMitochondrial oxidative phosphorylationDisseminated candidiasisC. tropicalisMyeloid-derived suppressor cellsAntifungal immunityOxidative phosphorylationAcute kidney injuryMolecular mechanismsExpression of solute carrier family 7 memberExpression of mitochondrial proteinsInhibition of mitochondrial oxidative phosphorylationKidney injurySolute carrier family 7 memberSusceptible to ferroptosisRNA sequencing analysisCandida tropicalisQuantitative real-time PCRHost antifungal immunityMitochondrial proteinsC-type lectin receptorsIncreased susceptibility to acute kidney injuryProportion of myeloid-derived suppressor cellsCARD9Susceptibility to acute kidney injuryReal-time PCR
2022
Targeted Isolation of Two New Anti-inflammatory and UV-A Protective Dipyrroloquinones from the Sponge-associated Fungus Aspergillus tamarii MCCF102 #
Niveditha L, Fu P, Leao T, Li T, Wang T, Poulin R, Gaspar L, Naman C, Puthiyedathu S. Targeted Isolation of Two New Anti-inflammatory and UV-A Protective Dipyrroloquinones from the Sponge-associated Fungus Aspergillus tamarii MCCF102 #. Planta Medica 2022, 88: 774-782. PMID: 35148546, DOI: 10.1055/a-1769-8480.Peer-Reviewed Original Research
2021
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease
Pokhilko A, Brezzo G, Handunnetthi L, Heilig R, Lennon R, Smith C, Allan S, Granata A, Sinha S, Wang T, Markus H, Naba A, Fischer R, Van Agtmael T, Horsburgh K, Cader M. Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease. Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2423-2438. PMID: 33730931, PMCID: PMC8392779, DOI: 10.1177/0271678x211004307.Peer-Reviewed Original Research