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Postdoctoral position in single-cell genomics, bioinformatics, and immunology of HIV persistence and cure

Ho Lab, Yale University School of Medicine

The Ho Lab at Yale University School of Medicine is recruiting motivated, productive, independent, and collegial postdoctoral research associates interested in innovative single-cell genomics on HIV-induced immune dysfunction and HIV persistence. This postdoctoral researcher will combine wet-bench molecular biology methods, dry-lab bioinformatic analysis, and a translational approach using clinical samples from people with HIV. The overall goal is to understand mechanism of HIV persistence and guide the development of HIV cure strategies. The immediate project will involve single-cell multi-omic profiling of clinical samples from people living with HIV (bioRxiv 2021, in press at Immunity).

The postdoctoral training will involve

  • The development and application of innovative single-cell RNAseq methods,
  • Bioinformatic analysis of single-cell genomics datasets,
  • A translational approach using blood or tissue samples from humans,
  • Wet-bench methods in virology (such as sterile cell culture in an enhanced biosafety level 2 (BSL2+) lab), immunology (such as flow cytometry), and molecular biology (such as CRISPR, real-time PCR, and western blot),
  • Collaboration with other researchers both inside and outside of Yale, including virologists, immunologists, bioinformaticians, computer scientists, and clinicians,
  • Presentation in international conferences, and
  • Manuscript preparation and grant applications.

Funded by several NIH grants (R01, R61, and UM1), our lab provides a collaborative environment and multi-disciplinary training for scientific and career development. Our lab has a track record of training postdoctoral researchers: our postdocs have international conference presentations and first-authored original articles (Science Translational Medicine and JCI) within three years after they joined the lab. Our lab members have received New Investigator Award, Pilot Grant, and travel grants in the past three years. Our lab is dedicated to recruiting researchers from a diverse background.

A successful candidate will likely have:

  • A recent (<4 years) PhD degree in bioinformatics, genomics, genetics, microbiology, molecular biology, immunology, or a related discipline;
  • A track record of research productivity, as evidenced by first-authored original publication(s) in high-quality peer-reviewed journals;
  • Experience in programming languages such as R or python;
  • Willingness to work with HIV+ samples following BSL2+ procedures;
  • Independence to lead a project as well as willingness to work in a team;
  • An open mind to learn new methods from junior researchers and collaborators;
  • Good scientific presentation and writing skills.
Previous experience and publications in bioinformatics, immunology, or virology is preferred but not required. People who have no interest in bioinformatic analysis should not apply. Salary will be commensurate with experience and qualifications.

Interested candidates may send a CV, a personal statement, and the contact information for three referees to This position is immediately available. Applications will be reviewed on a rolling basis until the position is filled.

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Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.