WEBVTT

NOTE duration: "00:03:03.637"


NOTE Confidence: 0.9323151

00:00:04.319 --> 00:00:06.259
Lineage plasticity is a process

NOTE Confidence: 0.9323151

00:00:06.399 --> 00:00:07.759
which cancer cell can change

NOTE Confidence: 0.9323151

00:00:07.759 --> 00:00:08.420
their identity

NOTE Confidence: 0.9422385

00:00:08.880 --> 00:00:10.639
and become someone they are

NOTE Confidence: 0.9422385

00:00:10.639 --> 00:00:12.160
not before. Think about the

NOTE Confidence: 0.9422385

00:00:12.160 --> 00:00:13.759
whole concept of any anti

NOTE Confidence: 0.9422385

00:00:13.759 --> 00:00:15.325
cancer treatment. These kinds of

NOTE Confidence: 0.9422385

00:00:15.325 --> 00:00:17.165
cell have some identity, make

NOTE Confidence: 0.9422385

00:00:17.165 --> 00:00:18.685
them different from normal cells.

NOTE Confidence: 0.9422385

00:00:18.685 --> 00:00:19.885
Right? So we can target

NOTE Confidence: 0.9422385

00:00:19.885 --> 00:00:21.565
them by our anti cancer

NOTE Confidence: 0.9422385

00:00:21.565 --> 00:00:22.065
therapies.

NOTE Confidence: 0.9489499

00:00:26.045 --> 00:00:27.565
My lab, trying to answer

NOTE Confidence: 0.9489499

00:00:27.565 --> 00:00:28.545
three big questions.

NOTE Confidence: 0.9715563

00:00:28.925 --> 00:00:29.744
First is

NOTE Confidence: 0.94705665

00:00:30.090 --> 00:00:31.690
why cancer cell are able

NOTE Confidence: 0.94705665

00:00:31.690 --> 00:00:33.050
to escape the anti cancer

NOTE Confidence: 0.94705665

00:00:33.050 --> 00:00:34.409
therapy we designed for them,

NOTE Confidence: 0.94705665

00:00:34.409 --> 00:00:35.450
and how can we stop

NOTE Confidence: 0.94705665

00:00:35.450 --> 00:00:37.470
that? And second question is

NOTE Confidence: 0.94705665

00:00:37.770 --> 00:00:39.390
most of anti cancer therapy

NOTE Confidence: 0.94705665

00:00:39.450 --> 00:00:41.050
only work in a small

NOTE Confidence: 0.94705665

00:00:41.050 --> 00:00:42.729
proportion of patient. So we

NOTE Confidence: 0.94705665

00:00:42.729 --> 00:00:44.005
want to know, can we

NOTE Confidence: 0.94705665

00:00:44.005 --> 00:00:45.205
actually find a way to

NOTE Confidence: 0.94705665

00:00:45.205 --> 00:00:47.445
predict which patient responds to

NOTE Confidence: 0.94705665

00:00:47.445 --> 00:00:49.525
which therapy and match the

NOTE Confidence: 0.94705665

00:00:49.525 --> 00:00:51.125
perfect therapy for the perfect

NOTE Confidence: 0.94705665

00:00:51.125 --> 00:00:51.625
patient?

NOTE Confidence: 0.92702305

00:00:52.165 --> 00:00:53.445
And third is we try

NOTE Confidence: 0.92702305

00:00:53.445 --> 00:00:55.285
and develop new therapies for

NOTE Confidence: 0.92702305

00:00:55.285 --> 00:00:57.205
some cancer do not respond

NOTE Confidence: 0.92702305

00:00:57.205 --> 00:00:59.205
to any therapy exist right

NOTE Confidence: 0.92702305

00:00:59.205 --> 00:01:00.399
now. Now. So we are

NOTE Confidence: 0.92702305

00:01:00.399 --> 00:01:01.520
working very close to the

NOTE Confidence: 0.92702305

00:01:01.520 --> 00:01:04.000
physician colleagues at Yale and

NOTE Confidence: 0.92702305

00:01:04.000 --> 00:01:05.440
using all the cutting edge

NOTE Confidence: 0.92702305

00:01:05.440 --> 00:01:06.880
technology in my lab trying

NOTE Confidence: 0.92702305

00:01:06.880 --> 00:01:07.920
to solve these three big

NOTE Confidence: 0.92702305

00:01:07.920 --> 00:01:08.420
questions.

NOTE Confidence: 0.919081

00:01:12.145 --> 00:01:13.905
This small rare clone has

NOTE Confidence: 0.919081

00:01:13.905 --> 00:01:15.025
the ability to change it

NOTE Confidence: 0.919081

00:01:15.025 --> 00:01:16.305
to some different cell it

NOTE Confidence: 0.919081

00:01:16.305 --> 00:01:18.145
doesn't look like. But with

NOTE Confidence: 0.919081

00:01:18.145 --> 00:01:20.145
special transatomic and single cell,

NOTE Confidence: 0.919081

00:01:20.145 --> 00:01:21.425
first we can mapping them.

NOTE Confidence: 0.919081

00:01:21.425 --> 00:01:22.625
We can know what you're

NOTE Confidence: 0.919081

00:01:22.625 --> 00:01:23.745
actually changing to a new

NOTE Confidence: 0.919081

00:01:23.745 --> 00:01:25.525
one. And with artificial intelligence,

NOTE Confidence: 0.9572992

00:01:25.850 --> 00:01:27.289
which AI do the best,

NOTE Confidence: 0.9572992

00:01:27.289 --> 00:01:28.890
is find a pattern. We

NOTE Confidence: 0.9572992

00:01:28.890 --> 00:01:30.409
do not what your identity

NOTE Confidence: 0.9572992

00:01:30.409 --> 00:01:31.929
is, but we can capture

NOTE Confidence: 0.9572992

00:01:31.929 --> 00:01:33.229
the pattern you change

NOTE Confidence: 0.8740966

00:01:33.929 --> 00:01:35.450
and then design three d

NOTE Confidence: 0.8740966

00:01:35.450 --> 00:01:36.429
cultured organoid.

NOTE Confidence: 0.9074259

00:01:37.049 --> 00:01:38.329
Organoid, you can think about

NOTE Confidence: 0.9074259

00:01:38.329 --> 00:01:39.709
is like a mini pseudotumor.

NOTE Confidence: 0.90351963

00:01:40.275 --> 00:01:41.815
We can generate those pseudotumor

NOTE Confidence: 0.96516126

00:01:42.115 --> 00:01:43.715
from a patient tumor, which

NOTE Confidence: 0.96516126

00:01:43.715 --> 00:01:45.235
means we can test a

NOTE Confidence: 0.96516126

00:01:45.235 --> 00:01:47.735
specific drug. Basically, we predict

NOTE Confidence: 0.96516126

00:01:47.955 --> 00:01:49.315
your next move and give

NOTE Confidence: 0.96516126

00:01:49.315 --> 00:01:50.595
you the drug already waiting

NOTE Confidence: 0.96516126

00:01:50.595 --> 00:01:51.095
there.

NOTE Confidence: 0.996533

00:01:51.795 --> 00:01:52.535
This platform

NOTE Confidence: 0.9676748

00:01:52.915 --> 00:01:54.135
works close together.

NOTE Confidence: 0.86634016

00:01:54.515 --> 00:01:55.015
Basically,

NOTE Confidence: 0.793508

00:01:55.395 --> 00:01:55.895
it's

NOTE Confidence: 0.7280558

00:01:56.250 --> 00:01:56.750
examine,

NOTE Confidence: 0.87983674

00:01:57.210 --> 00:01:57.710
prediction,

NOTE Confidence: 0.9988694

00:01:59.050 --> 00:01:59.790
and testing

NOTE Confidence: 0.9177736

00:02:00.170 --> 00:02:01.850
and will help us to

NOTE Confidence: 0.9177736

00:02:01.850 --> 00:02:03.310
solve the three big questions.

NOTE Confidence: 0.915801

00:02:06.890 --> 00:02:08.250
If we can find all

NOTE Confidence: 0.915801

00:02:08.250 --> 00:02:10.615
those rare cologne for not

NOTE Confidence: 0.915801

00:02:10.675 --> 00:02:12.035
all the tumor, but every

NOTE Confidence: 0.915801

00:02:12.035 --> 00:02:12.935
different patient,

NOTE Confidence: 0.9470383

00:02:13.235 --> 00:02:14.675
each of the rare cologne

NOTE Confidence: 0.9470383

00:02:14.675 --> 00:02:15.955
which cause their tumor may

NOTE Confidence: 0.9470383

00:02:15.955 --> 00:02:17.315
relapse in the future, and

NOTE Confidence: 0.9470383

00:02:17.315 --> 00:02:18.775
then we can design therapies

NOTE Confidence: 0.9606122

00:02:19.075 --> 00:02:20.355
to stop that before the

NOTE Confidence: 0.9606122

00:02:20.355 --> 00:02:21.415
tumor even relapses.

NOTE Confidence: 0.92700666

00:02:21.875 --> 00:02:23.100
And the second goal is

NOTE Confidence: 0.92700666

00:02:23.340 --> 00:02:25.260
use this precision medicine which

NOTE Confidence: 0.92700666

00:02:25.260 --> 00:02:26.880
based on AI algorithm prediction

NOTE Confidence: 0.92700666

00:02:27.100 --> 00:02:28.960
and those little pseudo tumor

NOTE Confidence: 0.92700666

00:02:29.020 --> 00:02:29.760
group platform.

NOTE Confidence: 0.95555216

00:02:30.139 --> 00:02:31.920
We can give each patient

NOTE Confidence: 0.95555216

00:02:32.060 --> 00:02:33.920
a very different treatment design

NOTE Confidence: 0.95555216

00:02:33.980 --> 00:02:35.280
based on AI prediction.

NOTE Confidence: 0.9345297

00:02:36.695 --> 00:02:38.155
And we'll have the most

NOTE Confidence: 0.9345297

00:02:38.294 --> 00:02:39.895
effective treatment before you even

NOTE Confidence: 0.9345297

00:02:39.895 --> 00:02:41.095
give the patient to help

NOTE Confidence: 0.9345297

00:02:41.095 --> 00:02:42.315
our physician colleagues.

NOTE Confidence: 0.95757115

00:02:43.895 --> 00:02:45.095
Right now, our lab is

NOTE Confidence: 0.95757115

00:02:45.095 --> 00:02:46.375
working on prostate cancer and

NOTE Confidence: 0.95757115

00:02:46.375 --> 00:02:48.215
also bladder cancer, and especially

NOTE Confidence: 0.95757115

00:02:48.215 --> 00:02:49.575
because we're in the urology

NOTE Confidence: 0.95757115

00:02:49.575 --> 00:02:49.950
department.

NOTE Confidence: 0.9130727

00:02:50.430 --> 00:02:51.709
But you can see the

NOTE Confidence: 0.9130727

00:02:51.709 --> 00:02:53.150
platform we built, the AI

NOTE Confidence: 0.9130727

00:02:53.150 --> 00:02:55.069
system, the special transatomic, and

NOTE Confidence: 0.9130727

00:02:55.069 --> 00:02:55.730
the pseudotumor,

NOTE Confidence: 0.9959097

00:02:56.110 --> 00:02:57.230
we can use the same

NOTE Confidence: 0.9959097

00:02:57.230 --> 00:02:58.849
platform to any different cancers.