Yale YCCI Resources for Innovations in Clinical Investigation

April 11, 2022

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00:00First, I want to thank
00:02all the speakers today.
00:04These were really wonderful
00:05presentations and give you a sense
00:07of the the life and innovation
00:10and excitement in clinical and
00:13translational research here at Yale.
00:16And I. I also want to acknowledge
00:21that the that this symposium was
00:24planned in collaboration with my my
00:27compadre and partner in in crime.
00:29Brian Brian Smith does say crime,
00:31I mean clinical research Brian
00:34Smith and he wanted to be
00:36here today presenting to you,
00:39but unfortunately wasn't able to participate.
00:42He and I had planned a joint presentation to
00:45give you a 10,000 foot view of of YCI and.
00:50Clinical research where?
00:52A little bit behind,
00:52so I'm going to give you an 18,000 foot
00:55view of clinical research in NYC I.
01:00So the first thing to know about
01:01Ricci is it's a university resource.
01:04The various schools and components
01:06of the university all can take
01:08advantage of YCI and we try to
01:11support people across campus.
01:12We have a number of partnerships with
01:14all of the institutions that the
01:16medical school partnerships partners with,
01:18such as Yellow Haven health system,
01:20the VA and and Community collaborators.
01:24As you can see,
01:25there are a variety of components
01:26people talk about the complexity
01:28of why CI and that's.
01:30Aren't because we're doing so much
01:32and that we have teams of people
01:35working on each aspect of the
01:37components that are outlined here.
01:39You already heard that we provide
01:42support to research across the
01:44state of Connecticut in a variety
01:46of different contexts.
01:48And one of the important things is
01:50that that that we try to provide
01:54support to diverse Community
01:56communities across the state,
01:58and some of the success in that is
02:01that the composition of our research
02:03studies mirrors that of of the
02:06composition of the state of Connecticut.
02:08One of the things that people want
02:11most from ICI is just a little leg
02:13up to get their research project
02:15started and we have a variety of
02:17pilot grants that are provided.
02:20We've provided over $5 million to
02:22over 138 recipients across different
02:25schools and those hundred those grants
02:29have led to 159 grants over 316 publications.
02:35We have 6 categories of pilot grants.
02:38Some of those.
02:40They are specifically oriented
02:42towards supporting junior faculty
02:44community engaged research
02:46translational research team science.
02:48As you heard about earlier today,
02:50research across the lifespan and taking
02:53advantage of some of our particular cores.
02:57Strong research cores such
02:58as the imaging core.
03:02I I'm going to for the sake of brevity,
03:05just make the two most
03:07important points on this slide.
03:09The first is that there is a limited
03:11competition, small gradual grant
03:13award through the CSA Awards.
03:16The in R3 award and the next deadline
03:20is June 17th, 2022 for those awards.
03:24And to enhance the capability
03:26of the CTA KL 2 scholars.
03:29In other words,
03:30the ones CI scholars to.
03:34And recipients of diversity and reentry
03:37supplements to to get pilot research going.
03:41Also, there's a limited competition. Also,
03:45supplements to promote diverse and health.
03:49Promote diversity and health related research
03:51and that deadline is coming up in November.
03:54If you're interested in
03:56either of these programs,
03:57please do not hesitate to reach out to us
04:00and we can help help you get connected.
04:03There will be a new award I'm I'm not going
04:06to go into this detail the the whole YC.
04:09I grant the CTS a grant has been
04:13restructured and a new grant
04:16mechanism has been introduced,
04:18but we do not, we we we do not.
04:22We're not currently funded by that mechanism,
04:24but we we will be going in for those
04:28kinds of grants in the future.
04:30There's a a program,
04:32supported through NCATS,
04:33which is the sponsoring organization
04:35for why CI one program that's an
04:39R21 program in rare diseases,
04:41another one,
04:42an earlier phase program for called
04:45an RO 3 grant for rare diseases
04:48and and essentially why CI can
04:51help people get to get connected to
04:54these to these kinds of awards,
04:57even though they're not
04:58awarded directly at you.
05:00And they'll they'll be a
05:02call for a proposal soon.
05:05For example,
05:05for a coordinating Center
05:07for a rare disease network,
05:09which is usually for programs
05:11that are relatively more mature
05:14and have the ability to to.
05:17Lead Multicentered initiatives
05:18along the lines of what you
05:20heard from Doctor Mcpartland.
05:25It is frequently the case that multi
05:28center grants are are supported through
05:31mcats and then faculty at Yale are
05:34invited to join or apply to be local site
05:38investigators and multicenter studies.
05:412 examples of those that are
05:43ongoing at Yale right now.
05:45One by Sandy Springer related to in,
05:49in her case, Yale is the hub,
05:50the primary hub and it's.
05:53Testing a a long acting version of
05:56buprenorphine delivered in the context
05:59of infectious disease treatment
06:01and another grant where we're a
06:04site in a multi center study led by
06:07Merritt Chowansky in the department.
06:09Psychiatry and emergency medicine
06:11where they're evaluating a mobile
06:14health platform for early detection
06:15and treatment of prolonged opiate use.
06:21The YCI scholars, the K awardees,
06:23the people who get career development
06:25support that you've heard about,
06:26have done extraordinarily well.
06:2998% of them are still in engaged in research.
06:32They've generated $900 million
06:34in grants over 7500 publications.
06:37So, So what you've heard from our K awardees,
06:43the YCI scholars and former Y CI
06:46scholars has been generally true.
06:48And as you've heard,
06:50there are a number of programs
06:53that are associated with YC I,
06:55which are ongoing in our community and
06:58intended to help people to develop and kick
07:02start their developing research careers.
07:04One of those is the national
07:06Clinical Scholars program.
07:07Again, the most important bit of
07:09information you need to know is
07:12that the jet deadline is July 15th
07:14for those for those applications,
07:16the investigative medicine program,
07:18which is a PhD.
07:20Program for clinician scientists,
07:22and again the the most important
07:25thing you need to know that
07:27that deadline is January 2023.
07:29People in the investigative medicine
07:32program are often people who have completed
07:35not only completed medical training,
07:37but are either often in the
07:39residency or fellowship program or
07:42post residency post fellowship,
07:43and it's an opportunity to really
07:47transition to a research intensive career.
07:52NYC also funds predoctoral training
07:54and provides a great community of
07:57Predoctoral training in clinical
07:59and translational research.
08:01And then there are the YC
08:04I postdoctoral grants.
08:05The Predoctoral applications
08:08are due very soon, April 8th,
08:11as are the postdoctoral grants.
08:16Again, additional funding.
08:18There's the Doris Duke Fund to
08:21retain clinical scientists.
08:23And to these are support early
08:27career physician scientists who face
08:30significant caregiving demands.
08:31In other words, family demands
08:34and the next application cycle
08:37will probably be in in early 2023
08:41and then the YCI Scholar Awards,
08:43which which probably most of
08:45you are very familiar,
08:46which are the typical grants that are
08:49submitted and funded through YMCA to
08:51provide pilot funding that I was referred.
08:54For frying to eat earlier.
08:57You've heard a lot about
08:59the cultural ambassadors.
09:00It's a wonderful program,
09:01and we're so proud to to have such
09:04wonderful collaborations that makes all
09:06the work that we do so much better.
09:09One of the one of the big challenges
09:11that people face in in initiating
09:13clinical and translational research is
09:15often to get biostatistical support,
09:17or sometimes bioinformatics support
09:19and the Yale Center for Analytical
09:23Sciences or WICAST provides support.
09:25It's stretched very thin.
09:27It's providing support to a large
09:29number of people and we're trying
09:31to figure out how to optimize the
09:33utilization and support for that resource.
09:35We recognize that for some people
09:37it's hard to get.
09:39The support you need,
09:40but you should know that a lot of
09:43people are are are are utilizing the
09:45resource and and and and we try to
09:48support as many people as possible.
09:50COVID obviously presented us
09:51with a number of challenges.
09:54One of those was that the HRU unit in the
09:59East pavilion was used for treating patients,
10:04so our research number of inpatient
10:06research beds has declined and so.
10:09What we're trying to do to to respond
10:13to that is to create an equivalent
10:17resource in two places,
10:19one in the Yale Physicians Building
10:211 in Masonic Care.
10:22These we, we hope,
10:24will will,
10:25will be available in the upcoming year.
10:29As you know,
10:30we have the two churches S clinical
10:32resources which continue to be available
10:34and have been as busy or busier than ever.
10:37As you heard from Tisha's data.
10:39Earlier we have an open and active CRC
10:43providing support to clinical research.
10:46It's currently it's at the West Campus site.
10:49It's supporting COVID research.
10:51It's also supporting research in needing in
10:54with research rooms that need ventilation,
10:56such as research that might involve vaping
11:00or smoke inhalation or or related topics,
11:04and for those of us who were
11:07in the chairs meeting today,
11:09we heard about a new research.
11:11Building,
11:11which is planned for the space
11:13across the street from Boyer and
11:16from the School of Public Health.
11:18That will be the long term home of of
11:21translational and clinical research,
11:22and in a few years for those of us
11:25who who have been here long enough.
11:27Most of us know this black as
11:28the home of herbs,
11:29which was a diner that used to have
11:32a complete breakfast for $1.99.
11:35Now it will be the future home of
11:39of clinical translational research.
11:42Let me just close by saying so
11:44we can stay
11:45in time that the most important
11:47thing to know is contact us.
11:49There's a lot of information on the website.
11:52It provides a lot of guidance about how
11:54you can get access to the YCI resource,
11:56but if you can't,
11:58if you're struggling to figure out
11:59how to get access to those resources,
12:02you can contact. Miss Johnson Harris.
12:05You can contact me. You can contact Brian.
12:08You can contact the staff,
12:09we'll we'll do what we can to help people
12:13get on the road to clinical research.
12:15I think for the sake of.
12:18Time I am going to just say one other thing,
12:21which is that that one of the one of the
12:25things that YC I does that upsets people
12:28is that we're we provide a lot of the
12:31regulatory support for clinical trials.
12:34That means Ind.
12:37That means clinicaltrials.gov registration
12:39and and I hope you understand when
12:41we contact you and tell you that
12:43you have to do this or you have to
12:45do that or you have to take a break
12:47until you take care of the paperwork.
12:49Is we're trying to protect you
12:51that you are personally liable if
12:53you don't register your trials
12:55and clinical trials that Gov.
12:57You can be personally liable if
13:00you violate the conditions of the
13:02Ind and don't and don't update
13:04your ID's appropriately.
13:05And and there's also an institutional
13:08liability that we are are charged
13:10with being involved with,
13:11so sometimes we're going to ask you to
13:14do things that you don't like to do and
13:15might cost a little bit of money to do,
13:17but we're trying to do it to protect you.
13:20So I'm going to stop there,
13:22and I think we will invite the Dean
13:25to make a few closing comments
13:27and and just to say thank you to
13:31everybody who's presented today.
13:33What wonderful,
13:33exciting research is going on here.
13:36And thank everybody who's
13:38attended and participated.
13:39Thanks to Doctor Greenberg for
13:41his great opening presentation
13:42and now we welcome Dean Brown.