Linda Lin
she/her/hers
About
Research
Publications
Featured Publications
Human genetic diversity alters off-target outcomes of therapeutic gene editing.
Cancellieri S, Zeng J, Lin LY, Tognon M, Nguyen MA, Lin J, Bombieri N, Maitland SA, Ciuculescu MF, Katta V, Tsai SQ, Armant M, Wolfe SA, Giugno R, Bauer DE, Pinello L. Human genetic diversity alters off-target outcomes of therapeutic gene editing. Nat Genet 2022 PMID: 36522432, DOI: 10.1038/s41588-022-01257-y.Peer-Reviewed Original Research
2024
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells.
Zeng J, Nguyen MA, Liu P, da Silva LF, Levesque S, Lin LY, Justus DG, Petri K, Clement K, Porter SN, Verma A, Neri NR, Rosanwo T, Ciuculescu MF, Abriss D, Mintzer E, Maitland SA, Demirci S, Cha HJ, Orkin SH, Tisdale JF, Williams DA, Zhu LJ, Pruett-Miller SM, Pinello L, Joung JK, Pattanayak V, Manis JP, Armant M, Pellin D, Brendel C, Wolfe SA, Bauer DE. Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells. Cell Stem Cell 2024 PMID: 39672163, DOI: 10.1016/j.stem.2024.11.001.Peer-Reviewed Original Research
2023
Crystal Structure of an i-Motif from the HRAS Oncogene Promoter.
Li KS, Jordan D, Lin LY, McCarthy SE, Schneekloth JS Jr, Yatsunyk LA. Crystal Structure of an i-Motif from the HRAS Oncogene Promoter. Angew Chem Int Ed Engl 2023, 62: e202301666. PMID: 36995904, DOI: 10.1002/anie.202301666.Peer-Reviewed Original Research
2020
Identification and Characterization of a B-Raf Kinase α-Helix Critical for the Activity of MEK Kinase in MAPK Signaling.
Nguyen D, Lin LY, Zhou JO, Kibby E, Sia TW, Tillis TD, Vapuryan N, Xu MR, Potluri R, Shin Y, Erler EA, Bronkema N, Boehlmer DJ, Chung CD, Burkhard C, Zeng SH, Grasso M, Acevedo LA, Marmorstein R, Fera D. Identification and Characterization of a B-Raf Kinase α-Helix Critical for the Activity of MEK Kinase in MAPK Signaling. Biochemistry 2020, 59: 4755-4765. PMID: 33272017, PMCID: PMC8407401, DOI: 10.1021/acs.biochem.0c00598.Peer-Reviewed Original ResearchBiophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX.
Lin LY, McCarthy S, Powell BM, Manurung Y, Xiang IM, Dean WL, Chaires B, Yatsunyk LA. Biophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX. PloS One 2020, 15: e0241513. PMID: 33206666, PMCID: PMC7673559, DOI: 10.1371/journal.pone.0241513.Peer-Reviewed Original Research
2019
N-methyl mesoporphyrin IX as a highly selective light-up probe for G-quadruplex DNA.
Yett A, Lin LY, Beseiso D, Miao J, Yatsunyk LA. N-methyl mesoporphyrin IX as a highly selective light-up probe for G-quadruplex DNA. Journal Of Porphyrins And Phthalocyanines 2019, 23: 1195-1215. PMID: 34385812, PMCID: PMC8356643, DOI: 10.1142/s1088424619300179.Peer-Reviewed Original Research
2018
Quadruplexes in 'Dicty': crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome.
Guédin A, Lin LY, Armane S, Lacroix L, Mergny JL, Thore S, Yatsunyk LA. Quadruplexes in 'Dicty': crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome. Nucleic Acids Research 2018, 46: 5297-5307. PMID: 29718337, PMCID: PMC6007418, DOI: 10.1093/nar/gky290.Peer-Reviewed Original Research