2017
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma
Scholl UI, Abriola L, Zhang C, Reimer EN, Plummer M, Kazmierczak BI, Zhang J, Hoyer D, Merkel JS, Wang W, Lifton RP. Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma. Journal Of Clinical Investigation 2017, 127: 2739-2750. PMID: 28604387, PMCID: PMC5490757, DOI: 10.1172/jci91733.Peer-Reviewed Original ResearchConceptsAldosterone-producing adenomaAldosterone productionAdrenocortical cancer cell lineKCNJ5 potassium channelPotassium channel KCNJ5Motilin receptor agonistSteroid hormone aldosteroneMillions of casesAPA diagnosisCancer cell linesSevere hypertensionAdrenal glandReceptor agonistBenign tumorsHormone aldosteroneCalcium influxInvasive proceduresKCNJ5 mutationsAdrenocortical cellsNoninvasive diagnosisPotassium channelsMembrane depolarizationDiagnosisCell proliferationCell lines
2007
Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients
Murray TS, Egan M, Kazmierczak BI. Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Current Opinion In Pediatrics 2007, 19: 83-88. PMID: 17224667, DOI: 10.1097/mop.0b013e3280123a5d.Peer-Reviewed Original ResearchConceptsCystic fibrosis patientsChronic colonizationAcute infectionFibrosis patientsCystic fibrosisP. aeruginosaChronic pulmonary colonizationChronic pulmonary diseaseCystic fibrosis airwayHost immune systemMucoid P. aeruginosaP. aeruginosa behaviorCystic fibrosis lungPulmonary diseaseClinical benefitChronic infectionP. aeruginosa pathogenesisLeading causePulmonary colonizationNew therapiesImmune systemAggressive usePotential therapeuticsInfectionPatients