2020
A Screen for Antibiotic Resistance Determinants Reveals a Fitness Cost of the Flagellum in Pseudomonas aeruginosa
Rundell EA, Commodore N, Goodman AL, Kazmierczak BI. A Screen for Antibiotic Resistance Determinants Reveals a Fitness Cost of the Flagellum in Pseudomonas aeruginosa. Journal Of Bacteriology 2020, 202: 10.1128/jb.00682-19. PMID: 31871033, PMCID: PMC7043666, DOI: 10.1128/jb.00682-19.Peer-Reviewed Original ResearchConceptsFlagellar assemblyFitness advantageFitness costsCell envelopeOuter membrane barrier functionOuter membrane biogenesisUnbiased high-throughput approachOuter membrane barrierMembrane barrier functionHigh-throughput approachMembrane biogenesisGram-negative bacteriaFlagellar functionInsertion sequencingOuter membraneGene productsPresence of linezolidPresence of antibioticsAntibiotic resistance determinantsMembrane barrierAntibiotic entryFitnessEfflux pumpsGlycopeptide antibiotic vancomycinGenes
1994
pIV, a Filamentous Phage Protein that Mediates Phage Export Across the Bacterial Cell Envelope, Forms a Multimer
Kazmierczak B, Mielke D, Russel M, Model P. pIV, a Filamentous Phage Protein that Mediates Phage Export Across the Bacterial Cell Envelope, Forms a Multimer. Journal Of Molecular Biology 1994, 238: 187-198. PMID: 8158648, DOI: 10.1006/jmbi.1994.1280.Peer-Reviewed Original ResearchConceptsSpecific substrate proteinsBacterial cell envelopeOuter membrane proteinsBacterial homologSubstrate proteinsMixed multimersPhage assemblyMembrane proteinsPhage proteinsOuter membraneCell envelopeHomologous proteinsExtracellular milieuProtein secretionEscherichia coliFilamentous phageGated channelProteinSame cellsSpecialized formMultimersPhagesHomologSedimentation experimentsSpheroplasts