2014
Altered global brain signal in schizophrenia
Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Altered global brain signal in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 7438-7443. PMID: 24799682, PMCID: PMC4034208, DOI: 10.1073/pnas.1405289111.Peer-Reviewed Original ResearchConceptsGlobal brain signalBrain dysfunctionHealthy subjectsBipolar patientsCortical powerBipolar disorderNeuropsychiatric conditionsFunctional MRIPatient samplesBrain connectivitySchizophreniaComplex neurobiologyDiagnostic specificityPatientsBrain signalsAlterationsDysfunctionSymptomsFindingsBaselineBrainMRI
2013
Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder
Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPrefrontal cortexResting-state functional connectivity dataStriatum/nucleus accumbensVentral striatum/nucleus accumbensResting-state functional connectivity studiesVentral anterior cingulate cortexCortico-striatal circuitsMagnetic Resonance Imaging AnalysisAnterior cingulate cortexFunctional connectivity studiesBasal gangliaControl subjectsFunctional connectivity dataAnterior thalamusRight putamenFrontal cortexNucleus accumbensDorsal striatumCerebellar cortexAbnormal neural connectivityCerebellar dysconnectivityCingulate cortexWhole brainFunctional magnetic resonance imaging (fMRI) analysisMulti-task connectivity reveals flexible hubs for adaptive task control
Cole MW, Reynolds JR, Power JD, Repovs G, Anticevic A, Braver TS. Multi-task connectivity reveals flexible hubs for adaptive task control. Nature Neuroscience 2013, 16: 1348-1355. PMID: 23892552, PMCID: PMC3758404, DOI: 10.1038/nn.3470.Peer-Reviewed Original ResearchRelationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans
Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT, Krystal JH. Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Molecular Psychiatry 2013, 18: 1199-1204. PMID: 23337947, PMCID: PMC3646075, DOI: 10.1038/mp.2012.194.Peer-Reviewed Original ResearchConceptsFunctional connectivityNegative symptomsGamma-aminobutyric acid (GABA) neuronsNMDA receptor antagonist ketamineAspartate glutamate receptor antagonistContinuous ketamine infusionGlutamate receptor antagonistsNMDA-R antagonistsCortical functional connectivityNMDA-R antagonist ketamineSchizophrenia-like symptomsHealthy human subjectsNegative Syndrome ScaleBrain functional connectivityPrimary samplesRegion-specific mannerFunctional magnetic resonanceKetamine infusionReceptor antagonistPathological increaseSyndrome ScaleSymptomsPreclinical researchKetamineBrain oscillations
2012
A broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference
Anticevic A, Repovs G, Krystal JH, Barch DM. A broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research 2012, 141: 8-14. PMID: 22863548, PMCID: PMC3879404, DOI: 10.1016/j.schres.2012.07.007.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBrain MappingFemaleFunctional LateralityHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory DisordersMemory, Short-TermMiddle AgedNerve NetNeural PathwaysNeuropsychological TestsOxygenPrefrontal CortexSchizophreniaSchizophrenic PsychologyConceptsFunctional connectivity abnormalitiesConnectivity abnormalitiesMedio-dorsal thalamusTask-based functional connectivityFinal common pathwayMaintenance phasePrefrontal cortical regionsDorsolateral prefrontal cortex activationPrefrontal cortex activationFunctional deficitsHealthy controlsSub-cortical regionsExtended amygdalaPatientsCortex activationCognitive deficitsCortical regionsFunctional connectivityLife outcomesAbnormalitiesDLPFC networkCommon pathwaySchizophrenia researchSchizophreniaMemory abnormalitiesGlobal Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence
Cole MW, Yarkoni T, Repovš G, Anticevic A, Braver TS. Global Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence. Journal Of Neuroscience 2012, 32: 8988-8999. PMID: 22745498, PMCID: PMC3392686, DOI: 10.1523/jneurosci.0536-12.2012.Peer-Reviewed Original ResearchConceptsCognitive controlHuman intelligenceSuch cognitive controlHigh control demandsControl of thoughtsHigh global connectivityLPFC regionsMemory taskFluid intelligenceIndividual differencesFrontoparietal networkControl demandsPrefrontal cortexSelective relationshipControl processRegion activityIntelligenceDiverse contextsGlobal connectivityConnectivityLPFCTaskCortexThoughtContext
2011
Automated landmark identification for human cortical surface-based registration
Anticevic A, Repovs G, Dierker DL, Harwell JW, Coalson TS, Barch DM, Van Essen DC. Automated landmark identification for human cortical surface-based registration. NeuroImage 2011, 59: 2539-2547. PMID: 21925612, PMCID: PMC3476835, DOI: 10.1016/j.neuroimage.2011.08.093.Peer-Reviewed Original ResearchVariable Global Dysconnectivity and Individual Differences in Schizophrenia
Cole MW, Anticevic A, Repovs G, Barch D. Variable Global Dysconnectivity and Individual Differences in Schizophrenia. Biological Psychiatry 2011, 70: 43-50. PMID: 21496789, PMCID: PMC3204885, DOI: 10.1016/j.biopsych.2011.02.010.Peer-Reviewed Original ResearchConceptsIndividual differencesWechsler Adult Intelligence Scale-Third EditionDorsolateral prefrontal cortex regionsState functional connectivity magnetic resonanceFunctional connectivity magnetic resonanceFocal brain regionsPrefrontal cortex regionsSternberg taskCognitive functioningPFC involvementCognitive deficitsDSM-IV schizophreniaSymptom domainsConnectivity methodsBrain regionsNegative symptomsSymptom severitySymptom presentationCortex regionsDysconnectivityHub regionsNeuropathology of schizophreniaSchizophreniaSuch findingsSymptom expressionEmotion Effects on Attention, Amygdala Activation, and Functional Connectivity in Schizophrenia
Anticevic A, Repovs G, Barch DM. Emotion Effects on Attention, Amygdala Activation, and Functional Connectivity in Schizophrenia. Schizophrenia Bulletin 2011, 38: 967-980. PMID: 21415225, PMCID: PMC3446234, DOI: 10.1093/schbul/sbq168.Peer-Reviewed Original ResearchConceptsAmygdala activationAmygdala recruitmentEmotional processingSimple perceptual decision tasksHigh-level cognitive processesFunctional connectivityRapid event-related fMRIPerceptual decision taskTask-based functional connectivityProcessing of affectEvent-related fMRIMinimal cognitive loadSCZ subjectsLevel of behaviorSignificant group differencesEmotion effectsNeutral distractionAffective cuesMoment perceptionsAffective stimuliNegative stimuliCognitive processesDecision taskNegative distractionCognitive load
2010
Resisting emotional interference: Brain regions facilitating working memory performance during negative distraction
Anticevic A, Barch D, Repovs G. Resisting emotional interference: Brain regions facilitating working memory performance during negative distraction. Cognitive, Affective, & Behavioral Neuroscience 2010, 10: 159-173. PMID: 20498341, PMCID: PMC3856369, DOI: 10.3758/cabn.10.2.159.Peer-Reviewed Original ResearchConceptsPrefrontal cortical regionsNegative distractionPrefrontal regionsEmotional interferenceNeutral distractionIncorrect trialsCortical regionsPrefrontal cortexNegative emotional distractionActive cognitive engagementLateral prefrontal regionsVentrolateral prefrontal regionsFrontopolar prefrontal cortexSurvival-relevant informationParietal cortical regionsEmotional distractionWM performanceCognitive operationsAmygdala signalMemory performanceCognitive engagementIndividual differencesAmygdala activityActivation differencesMore deactivation
2009
When less is more: TPJ and default network deactivation during encoding predicts working memory performance
Anticevic A, Repovs G, Shulman GL, Barch DM. When less is more: TPJ and default network deactivation during encoding predicts working memory performance. NeuroImage 2009, 49: 2638-2648. PMID: 19913622, PMCID: PMC3226712, DOI: 10.1016/j.neuroimage.2009.11.008.Peer-Reviewed Original ResearchConceptsTemporo-parietal junctionDefault mode networkWM performanceDMN deactivationSlow event-related fMRIDefault network deactivationBetter WM performanceTask-relevant featuresEvent-related fMRITypes of distractersVentral attention networkStronger functional connectivityRapid visual searchFunctional connectivity resultsWM encodingWM taskTask demandsDistracter stimuliMemory performanceCognitive engagementVisual searchFunctional dissociationIrrelevant objectsAttention networkMode network
2008
Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophrenia
Anticevic A, Dierker DL, Gillespie SK, Repovs G, Csernansky JG, Van Essen DC, Barch DM. Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophrenia. NeuroImage 2008, 41: 835-848. PMID: 18434199, PMCID: PMC2527864, DOI: 10.1016/j.neuroimage.2008.02.052.Peer-Reviewed Original Research