2014
Altered global brain signal in schizophrenia
Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Altered global brain signal in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 7438-7443. PMID: 24799682, PMCID: PMC4034208, DOI: 10.1073/pnas.1405289111.Peer-Reviewed Original ResearchConceptsGlobal brain signalBrain dysfunctionHealthy subjectsBipolar patientsCortical powerBipolar disorderNeuropsychiatric conditionsFunctional MRIPatient samplesBrain connectivitySchizophreniaComplex neurobiologyDiagnostic specificityPatientsBrain signalsAlterationsDysfunctionSymptomsFindingsBaselineBrainMRIVentral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness From Psychotic Bipolar Disorder and Schizophrenia
Anticevic A, Savic A, Repovs G, Yang G, McKay DR, Sprooten E, Knowles EE, Krystal JH, Pearlson GD, Glahn DC. Ventral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness From Psychotic Bipolar Disorder and Schizophrenia. Schizophrenia Bulletin 2014, 41: 133-143. PMID: 24782562, PMCID: PMC4266289, DOI: 10.1093/schbul/sbu051.Peer-Reviewed Original ResearchConceptsVentral anterior cingulate cortexBipolar illnessPsychosis historyWhole-brain connectivityBipolar patientsConnectivity alterationsBrain connectivityCo-occurring psychosisChronic schizophrenia patientsHealthy comparison subjectsBipolar disorder patientsPsychotic bipolar disorder patientsBipolar disorder groupAnterior cingulate cortexFunctional connectivity studiesPsychotic bipolar disorderLifetime psychosisChronic schizophreniaPsychotic symptomsDisorder patientsPatientsComparison subjectsSchizophrenia patientsBipolar disorderCingulate cortex
2012
Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History
Anticevic A, Brumbaugh MS, Winkler AM, Lombardo LE, Barrett J, Corlett PR, Kober H, Gruber J, Repovs G, Cole MW, Krystal JH, Pearlson GD, Glahn DC. Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History. Biological Psychiatry 2012, 73: 565-573. PMID: 22980587, PMCID: PMC3549314, DOI: 10.1016/j.biopsych.2012.07.031.Peer-Reviewed Original ResearchConceptsPsychosis historyRisk factorsBipolar patientsSymptom severityResting-state functional magnetic resonanceAmygdala-mPFC connectivityFronto-limbic dysfunctionSevere clinical courseBipolar I patientsEmotion regulation regionsPsychotic symptom severityFunctional magnetic resonanceClinical courseI patientsLimbic structuresBipolar illnessConnectivity deficitsAmygdala findingsConnectivity abnormalitiesPathophysiological modelBipolar IPatientsBipolar disorderDysconnectivityAbnormal inhibitionA broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference
Anticevic A, Repovs G, Krystal JH, Barch DM. A broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research 2012, 141: 8-14. PMID: 22863548, PMCID: PMC3879404, DOI: 10.1016/j.schres.2012.07.007.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBrain MappingFemaleFunctional LateralityHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory DisordersMemory, Short-TermMiddle AgedNerve NetNeural PathwaysNeuropsychological TestsOxygenPrefrontal CortexSchizophreniaSchizophrenic PsychologyConceptsFunctional connectivity abnormalitiesConnectivity abnormalitiesMedio-dorsal thalamusTask-based functional connectivityFinal common pathwayMaintenance phasePrefrontal cortical regionsDorsolateral prefrontal cortex activationPrefrontal cortex activationFunctional deficitsHealthy controlsSub-cortical regionsExtended amygdalaPatientsCortex activationCognitive deficitsCortical regionsFunctional connectivityLife outcomesAbnormalitiesDLPFC networkCommon pathwaySchizophrenia researchSchizophreniaMemory abnormalities
2011
Negative and Nonemotional Interference with Visual Working Memory in Schizophrenia
Anticevic A, Repovs G, Corlett PR, Barch DM. Negative and Nonemotional Interference with Visual Working Memory in Schizophrenia. Biological Psychiatry 2011, 70: 1159-1168. PMID: 21861986, DOI: 10.1016/j.biopsych.2011.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaAnalysis of VarianceArousalAttentionCase-Control StudiesCerebral CortexDiscrimination, PsychologicalEmotionsFemaleField Dependence-IndependenceHumansLinear ModelsMagnetic Resonance ImagingMaleMatched-Pair AnalysisMemory, Short-TermMiddle AgedReference ValuesSchizophreniaSchizophrenic PsychologyVisual PerceptionConceptsControl subjectsSCZ subjectsDSM-IV-diagnosed schizophreniaAberrant salience processingLevel-dependent imagingAbility of patientsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cortical regionsFunctional magnetic resonanceLevel-dependent activityPathophysiological mechanismsPatientsResonance imagingCortical regionsAberrant responsesSalience processingSchizophreniaPrefrontal regionsEffects of distractionSubjectsSpecific deficitsDeficitsMagnetic resonanceSimilar responses
2010
Amygdala Recruitment in Schizophrenia in Response to Aversive Emotional Material: A Meta-analysis of Neuroimaging Studies
Anticevic A, Van Snellenberg JX, Cohen RE, Repovs G, Dowd EC, Barch DM. Amygdala Recruitment in Schizophrenia in Response to Aversive Emotional Material: A Meta-analysis of Neuroimaging Studies. Schizophrenia Bulletin 2010, 38: 608-621. PMID: 21123853, PMCID: PMC3329999, DOI: 10.1093/schbul/sbq131.Peer-Reviewed Original ResearchConceptsAmygdala activationCritical clinical featuresGroup differencesAbnormal amygdala activationClinical featuresSchizophrenia showPatientsBilateral amygdalaMeta-AnalysisIntact recruitmentNeuroimaging studiesSchizophreniaMeta-analytic approachEmotional dysfunctionAmygdala recruitmentDysfunctionPresent findingsAmygdalaEmotional stimuliNumber of studiesActivationFormal meta-analytic approachRecruitmentResponseStimuli