Skip to Main Content
Ludwig Program for the Study of Neuroimmune Interactions in Dementia
YSM Home

INFORMATION FOR

Get Involved

Today, there are more than 55 million people worldwide living with dementia, seven million of whom are in the U.S. As of 2020, Alzheimer’s disease accounted for 60% of cases. There are currently no cures for Alzheimer’s or related disorders, and the urgency to develop effective treatments only grows. It is estimated that by 2050, Alzheimer’s will affect nearly 14 million people in the U.S. alone.

How Can You Help?

  • Researchers in Immunology

    It may be possible to develop immunotherapies to target microglia in the brains of people with Alzheimer’s and clear amyloid plaques more effectively. Altering microglial differentiation state may mitigate dementia pathology. Researchers don’t know yet the optimal strategy of modulating innate immunity in the brain and whether it might be associated with other health risks.

  • Researchers in Neuroscience

    It is clear that neurons and neural networks can be modified by the immune system locally and at a distance. Despite profound effects on brain function, the cellular and molecular basis for these effects and how they contribute to dementia remain poorly understood. Research into neuroimmune interactions is expected to illuminate novel mechanisms to regulate CNS activioty.

  • Researchers in Neurology

    Identifying new genetic associations for neurodegenerative diseases may lead to better strategies to detect, treat, and prevent the dementias. Clinical imaging may help researchers better understand changes in the brains of people with dementia, as well as help diagnose these disorders.

Contact Us

If you would like to get involved or be informed about news relating to the Ludwig Program for the Study of Neuroimmune Interactions in Dementia, please provide us with your email or email us at ludwig.neuroimmune@yale.edu and we will add you to our contact list.

Opportunities