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Transcription Factor KLF2 and Cardiovascular Disease

The Leducq project is built around the long-standing observation that atherosclerotic lesions occur preferentially in regions of arteries that, due to branching or sharp curvature, are subject to lower flow magnitude and disturbances in flow profiles, that is, flow that reverses or shows complicated changes in direction with each heartbeat. By contrast, regions of arteries with high, unidirectional flow are protected from disease, even in the presence of risk factors such as high cholesterol, hypertension, smoking and so on.

Funding, Coordinators, & Members


Foundation Leducq Transatlantic Network of Excellence

North American Coordinator

Martin Schwartz, USA

European Coordinator

Ralf Adams, Germany


Michael Potente, Germany
Mukesh Jain, USA
Mark Kahn, USA
Sarah De Val, UK


Hillary Barigye
Network Administrative Officer