2024
SPIKENET: An Evidence-Based Therapy for Long COVID
Elumalai N, Hussain H, Sampath N, Shamaladevi N, Hajjar R, Druyan B, Rashed A, Ramamoorthy R, Kenyon N, Jayakumar A, Paidas M. SPIKENET: An Evidence-Based Therapy for Long COVID. Viruses 2024, 16: 838. PMID: 38932130, PMCID: PMC11209161, DOI: 10.3390/v16060838.Peer-Reviewed Original ResearchCarcinoembryonic antigen-related cell adhesion molecule 1Murine hepatitis virus-1Post-acute sequelae of COVID-19SARS-CoV-2 variantsSARS-CoV-2Development of severe inflammationCell adhesion molecule 1Long-term complicationsAdhesion molecule 1Multiple organ damagePotential therapeutic benefitMultiple SARS-CoV-2 variantsEvidence-based therapiesSequelae of COVID-19ACE2 receptor-binding domainSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Severe inflammationTissue edemaOrgan damageRespiratory syndrome coronavirus 2Long COVIDMolecule 1Receptor-binding domainSyndrome coronavirus 2
2023
Kidney Damage in Long COVID: Studies in Experimental Mice
Ramamoorthy R, Hussain H, Ravelo N, Sriramajayam K, Di Gregorio D, Paulrasu K, Chen P, Young K, Masciarella A, Jayakumar A, Paidas M. Kidney Damage in Long COVID: Studies in Experimental Mice. Biology 2023, 12: 1070. PMID: 37626956, PMCID: PMC10452084, DOI: 10.3390/biology12081070.Peer-Reviewed Original ResearchNeutrophil gelatinase-associated lipocalinSARS-CoV-2 infectionAcute infectionTubular necrosisLong COVIDTGF-β1Severe acute tubular necrosisInitial SARS-CoV-2 infectionAcute tubular necrosisGelatinase-associated lipocalinCoV-2 infectionProtein levelsInfiltration of macrophagesDevelopment of edemaMultiple organ systemsMMP-7 protein levelsCommon complicationKidney complicationsTLR-2IL-18Kidney damageKIM-1Renal fibrosisYKL-40NGAL mRNA