David Peaper, MD, PhD

Research Interests

Bacterial Infections; Influenza, Human; Clostridium difficile; Clinical Laboratory Techniques; Organisms

Research Organizations

Laboratory Medicine: Clinical Microbiology Laboratory | Clinical Virology Laboratory | VA Connecticut Clinical Laboratories

CPIRT - Pulmonary Infection Research and Treatment

Office of Cooperative Research

Research Summary

I am interested in the interaction between basic and clinical sciences and using the tools and resources of the clinical and basic science research communities to further our understanding of the mechanisms of organism pathogenesis and improving diagnostics available for the more rapid and/or accurate identification of infectious diseases. I collaborate with Yale scientists to increase the clinical relevance of research projects as well as identify current gaps in diagnostic testing where advanced methods may improve patient care.

I also have an interest in both assessing the outcomes of laboratory interventions and testing practices on patient care and identifying ways to streamline laboratory practices to improve our ability to provide test results. We have identified areas for improvement for the implementation of rapid respiratory virus testing and its impact on antibiotic overuse. Additionally, working with others at Yale and YNHH, we have studied a number of interventions in practices to improve test utilization and decrease rates of hospital acquired infections.

Selected Publications

• Rapid Diagnosis of Influenza: State of the Art.

  Peaper D and Landry ML. Clinics in Laboratory Medicine. 2014. 34:365-385

• Response to Mold Contamination of Intravenous Magnesium Sulfate Produced by a Compounding Pharmacy.

  Boyce J.M., Lee L., Topal J., Peaper D.R., Balcezak T. JAMA Internal Medicine. 2014. 174: 630-631.

• Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult Outpatients.

  Green DA, Hitoaliaj L, Kotansky B, Campbell SM, Peaper DR. J Clin Microbiol. 2016 Dec;54(12):2950-2955.

• The Contribution of Extended-Spectrum β-Lactamases to Multidrug-Resistant Infections in Children.

  Murray T.S. and Peaper D.R. (2015). Curr. Opin. Pediatr. 27:124-131.

• Use of Imipenem to Detect KPC, NDM, OXA, IMP, and VIM Carbapenemase Activity from Gram Negative Rods in 75 Minutes Using LC-MS/MS.

  Kulkarni M.V., Tichy A.N., Pyka J.S., Murray T.S., Hodsdon M.E., Peaper D.R. (2014). J Clin Microbiol. 52:2500-5.

Full List of PubMed Publications

• Green DA, Hitoaliaj L, Kotansky B, Campbell SM, Peaper DR: Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult Outpatients. J Clin Microbiol. 2016 Dec; 2016 Sep 21. PMID: 27654334
• Flores-Carrero A, Labrador I, Paniz-Mondolfi A, Peaper DR, Towle D, Araque M: Nosocomial outbreak of extended-spectrum β-lactamase-producing Enterobacter ludwigii co-harbouring CTX-M-8, SHV-12 and TEM-15 in a neonatal intensive care unit in Venezuela. J Glob Antimicrob Resist. 2016 Dec; 2016 Oct 7. PMID: 27750157
• Sack J, Peaper DR, Mistry P, Malinis M: Clinical implications of Paracoccus yeeii bacteremia in a patient with decompensated cirrhosis. IDCases. 2017; 2016 Nov 23. PMID: 27920982
• Yamahiro A, Lau KH, Peaper DR, Villanueva M: Meningitis Caused by Candida Dubliniensis in a Patient with Cirrhosis: A Case Report and Review of the Literature. Mycopathologia. 2016 Aug; 2016 Apr 1. PMID: 27038312
• Banach DB, Peaper DR, Fortune BE, Emre S, Dembry LM: The clinical and molecular epidemiology of pre-transplant vancomycin-resistant enterococci colonization among liver transplant recipients. Clin Transplant. 2016 Mar; 2016 Feb 9. PMID: 26780305
• Ruggero MA, Peaper DR, Topal JE: Telavancin for refractory methicillin-resistant Staphylococcus aureus bacteremia and infective endocarditis. Infect Dis (Lond). 2015 Jun; 2015 Mar 6. PMID: 25746601
• Murray TS, Peaper DR: The contribution of extended-spectrum β-lactamases to multidrug-resistant infections in children. Curr Opin Pediatr. 2015 Feb. PMID: 25565574
• Peaper DR, Havill NL, Aniskiewicz M, Callan D, Pop O, Towle D, Boyce JM: Pseudo-outbreak of Actinomyces graevenitzii associated with bronchoscopy. J Clin Microbiol. 2015 Jan; 2014 Oct 29. PMID: 25355767
• Peaper DR, Landry ML: Rapid diagnosis of influenza: state of the art. Clin Lab Med. 2014 Jun. PMID: 24856533
• Boyce JM, Lee L, Topal J, Peaper DR, Balcezak T: Response to mold contamination of intravenous magnesium sulfate produced by a compounding pharmacy. JAMA Intern Med. 2014 Apr. PMID: 24493036
• Peaper DR, Landry ML: Laboratory diagnosis of viral infection. Handb Clin Neurol. 2014. PMID: 25015483
• Peaper DR, Kulkarni MV, Tichy AN, Jarvis M, Murray TS, Hodsdon ME: Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LC-MS/MS. Bioanalysis. 2013 Jan. PMID: 23330558
• Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA: NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011 May 27; 2011 May 12. PMID: 21565393
• Ichinohe T, Pang IK, Kumamoto Y, Peaper DR, Ho JH, Murray TS, Iwasaki A: Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A. 2011 Mar 29; 2011 Mar 14. PMID: 21402903
• Wearsch PA, Peaper DR, Cresswell P: Essential glycan-dependent interactions optimize MHC class I peptide loading. Proc Natl Acad Sci U S A. 2011 Mar 22; 2011 Mar 7. PMID: 21383180
• Vigneron N, Peaper DR, Leonhardt RM, Cresswell P: Functional significance of tapasin membrane association and disulfide linkage to ERp57 in MHC class I presentation. Eur J Immunol. 2009 Sep. PMID: 19701894
• Dong G, Wearsch PA, Peaper DR, Cresswell P, Reinisch KM: Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer. Immunity. 2009 Jan 16. PMID: 19119025
• Peaper DR, Cresswell P: The redox activity of ERp57 is not essential for its functions in MHC class I peptide loading. Proc Natl Acad Sci U S A. 2008 Jul 29; 2008 Jul 23. PMID: 18650385
• Peaper DR, Cresswell P: Regulation of MHC class I assembly and peptide binding. Annu Rev Cell Dev Biol. 2008. PMID: 18729726
• Peaper DR, Wearsch PA, Cresswell P: Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex. EMBO J. 2005 Oct 19; 2005 Sep 29. PMID: 16193070
• Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA: Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunol Rev. 2005 Oct. PMID: 16181333
• Dick TP, Bangia N, Peaper DR, Cresswell P: Disulfide bond isomerization and the assembly of MHC class I-peptide complexes. Immunity. 2002 Jan. PMID: 11825568

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