Study Identifies New Cell Type That Triggers Deadly Allergic Reactions
For millions of Americans, contact with certain foods can cause anaphylaxis, a life-threatening allergic reaction. A new study has uncovered a previously unknown cell type that promotes the reaction and could be used to identify individuals who are most at risk.
Fighting the Cold Virus and Other Threats, Body Makes Trade-off, Says Study
A Yale research team has revealed how cells in different parts of the human airway vary in their response to the common cold virus. Their finding, published in Cell Reports, could help solve the mystery of why some people exposed to the cold virus get ill while others don’t, said the researchers.
The Jackson Laboratory highlights collaboration with Dr. Stephanie Eisenbarth in Yale Laboratory Medicine
The spleen’s mechanisms for responding to blood-borne antigens mirror those in immune responses in other sites of the body, and could potentially be harnessed to prevent life-threatening immune responses in patients requiring frequent blood transfusions.Source: The Jackson Laboratory
Informatics Oversight Reduces Barriers to Conducting Research
Informatics support requires oversight to ensure that institutional policies and practices don’t become barriers to research. The Clinical Research Leadership Committee, led by Brian Smith, MD, professor and chair of laboratory medicine, is responsible for this guidance. Formed by the School of Medicine, Yale Medical Group (YMG), and Yale New Haven Health System (YNHHS), the committee is responsible for coordinating Yale’s health care delivery system with the translational research enterprise.
New research helps explain why the ‘cold virus’ prefers cold temperatures
Ellen Foxman, MD, PhD, one of Laboratory Medicine’s physician-scientist trainees working with Dr. Akiko Iwasaki of the Department of Immunobiology, recently discovered that the common cold virus can reproduce more efficiently in the cooler temperature found inside the nose than at core body temperature. This finding may confirm the popular, yet contested, notion that people are more likely to catch a cold in cool-weather conditions. See the full article in Yale News and Dr. Foxman’s interview onSource: YaleNews
Rhee: Trends in Co-Prescribing of Opioids and Opioid Potentiators Among U.S. Adults, 2007–2018
Lead author Greg Rhee, PhD, Assistant Professor Adjunct in the Department of Psychiatry, explores trends in co-prescribing opioids and opioid potentiators among U.S. adults in a recent article published in the American Journal of Preventive Medicine.Source: American Journal of Preventive Medicine
Treatment with Genetically Altered Viruses Targets and Destroys Ovarian Cancer in Mice
Researchers have successfully eliminated chemotherapy-resistant ovarian cancer cells in mice using a single injection of two viruses genetically combined and altered to be safe, leading to long-term survival and demonstrating a potential breakthrough treatment for women.
Systematic Review of Racial Disparities in Clozapine Prescribing
J. Corey Williams, MD, a graduate of the Yale Psychiatry Residency Program, collaborated with Cenk Tek, MD, Associate Professor of Psychiatry and Vinod Srihari, MD, Professor of Psychiatry to conduct a systematic review of published evidence on clozapine prescribing disparities across racial and ethnic categories.Source: Schizophrenia Research
Narrow-spectrum antibiotics viable treatment option for acne
Perceptions of antibiotics and potential antibiotic resistance have caused some physicians to be wary of the drug class when prescribing an acne treatment regimen. However, narrow-spectrum antibiotics have shown a low propensity for development of antimicrobial resistance while also effectively treating acne.Source: Dermatology Times
Clearing the Haze: What Do We Still Need to Learn About Electronic Nicotine Delivery Systems?
Important questions remain regarding the relative benefits versus risks of electronic nicotine delivery systems (ENDS). In light of these challenges, the authors propose key ENDS research priorities to address these gaps.Source: Cancer Prevention Research
Yale Study: Diaper Need is Associated with Pediatric Care Utilization
Kunmi Sobowale, MD; Ashley Clayton, MA; and Megan Smith, DrPH, MPH, co-authored a paper in The Journal of Pediatrics that found lack of access to diapers was associated with more frequent pediatric visits for treatment of diaper rash and urinary tract infections.Source: The Journal of Pediatrics